diff --git a/bindgen-tests/tests/expectations/tests/issue-2566-cstr.rs b/bindgen-tests/tests/expectations/tests/issue-2566-cstr.rs
new file mode 100644
index 0000000000..4227cf2956
--- /dev/null
+++ b/bindgen-tests/tests/expectations/tests/issue-2566-cstr.rs
@@ -0,0 +1,2 @@
+#![allow(dead_code, non_snake_case, non_camel_case_types, non_upper_case_globals)]
+pub const FOO: &[u8; 4] = b"a\0b\0";
diff --git a/bindgen-tests/tests/expectations/tests/issue-2566.rs b/bindgen-tests/tests/expectations/tests/issue-2566.rs
new file mode 100644
index 0000000000..4227cf2956
--- /dev/null
+++ b/bindgen-tests/tests/expectations/tests/issue-2566.rs
@@ -0,0 +1,2 @@
+#![allow(dead_code, non_snake_case, non_camel_case_types, non_upper_case_globals)]
+pub const FOO: &[u8; 4] = b"a\0b\0";
diff --git a/bindgen-tests/tests/headers/issue-2566-cstr.h b/bindgen-tests/tests/headers/issue-2566-cstr.h
new file mode 100644
index 0000000000..674b894024
--- /dev/null
+++ b/bindgen-tests/tests/headers/issue-2566-cstr.h
@@ -0,0 +1,4 @@
+// bindgen-flags: --generate-cstr
+
+/// We should _not_ generate a cstr for this because cstr shouldn't have interior nulls.
+#define FOO "a\0b"
diff --git a/bindgen-tests/tests/headers/issue-2566.h b/bindgen-tests/tests/headers/issue-2566.h
new file mode 100644
index 0000000000..6e15ec1979
--- /dev/null
+++ b/bindgen-tests/tests/headers/issue-2566.h
@@ -0,0 +1 @@
+#define FOO "a\0b"
diff --git a/bindgen/codegen/mod.rs b/bindgen/codegen/mod.rs
index 11425e02a4..3d99fa02c8 100644
--- a/bindgen/codegen/mod.rs
+++ b/bindgen/codegen/mod.rs
@@ -714,18 +714,18 @@ impl CodeGenerator for Var {
                     let len = proc_macro2::Literal::usize_unsuffixed(
                         cstr_bytes.len(),
                     );
-                    let cstr = CStr::from_bytes_with_nul(&cstr_bytes).unwrap();
 
                     // TODO: Here we ignore the type we just made up, probably
                     // we should refactor how the variable type and ty ID work.
                     let array_ty = quote! { [u8; #len] };
                     let cstr_ty = quote! { ::#prefix::ffi::CStr };
 
-                    let bytes = proc_macro2::Literal::byte_string(
-                        cstr.to_bytes_with_nul(),
-                    );
+                    let bytes = proc_macro2::Literal::byte_string(&cstr_bytes);
 
-                    if rust_features.const_cstr && options.generate_cstr {
+                    if options.generate_cstr &&
+                        rust_features.const_cstr &&
+                        CStr::from_bytes_with_nul(&cstr_bytes).is_ok()
+                    {
                         result.push(quote! {
                             #(#attrs)*
                             #[allow(unsafe_code)]