diff --git a/setup.cfg b/setup.cfg
index b69ff82..9d615bf 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -20,20 +20,17 @@ classifier =
     Intended Audience :: Developers
     License :: OSI Approved :: MIT License
     Operating System :: OS Independent
-    Programming Language :: Python :: 2
-    Programming Language :: Python :: 2.7
-    Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.4
-    Programming Language :: Python :: 3.5
-    Programming Language :: Python :: 3.6
     Programming Language :: Python :: 3.7
+    Programming Language :: Python :: 3.8
+    Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
     Topic :: Software Development :: Build Tools
     Topic :: Software Development :: Libraries :: Python Modules
     Topic :: Utilities
 
 [options]
 zip_safe = true
-python_requires = >=2.7,!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*
+python_requires = !=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*
 setup_requires = setuptools>=41.0
 include_package_data = true
 package_data =
@@ -42,10 +39,7 @@ package_data =
 install_requires =
     attrs
     cached-property
-    six
     packaging
-    backports.functools_lru_cache;python_version=="2.7"
-    pathlib2;python_version<"3.5"
 
 [options.packages.find]
 where = src
diff --git a/src/pythonfinder/compat.py b/src/pythonfinder/compat.py
index f1ac227..51fca95 100644
--- a/src/pythonfinder/compat.py
+++ b/src/pythonfinder/compat.py
@@ -1,21 +1,10 @@
 # -*- coding=utf-8 -*-
 import sys
 
-import six
+from pathlib import Path
 
-if sys.version_info[:2] <= (3, 4):
-    from pathlib2 import Path  # type: ignore  # noqa
-else:
-    from pathlib import Path
-
-if six.PY3:
-    from builtins import TimeoutError
-    from functools import lru_cache
-else:
-    from backports.functools_lru_cache import lru_cache  # type: ignore  # noqa
-
-    class TimeoutError(OSError):
-        pass
+from builtins import TimeoutError
+from functools import lru_cache
 
 
 def getpreferredencoding():
@@ -24,10 +13,6 @@ def getpreferredencoding():
     # Borrowed from Invoke
     # (see https://github.com/pyinvoke/invoke/blob/93af29d/invoke/runners.py#L881)
     _encoding = locale.getpreferredencoding(False)
-    if six.PY2 and not sys.platform == "win32":
-        _default_encoding = locale.getdefaultlocale()[1]
-        if _default_encoding is not None:
-            _encoding = _default_encoding
     return _encoding
 
 
diff --git a/src/pythonfinder/models/__init__.py b/src/pythonfinder/models/__init__.py
index 1a1f2db..e949709 100644
--- a/src/pythonfinder/models/__init__.py
+++ b/src/pythonfinder/models/__init__.py
@@ -5,8 +5,6 @@
 import operator
 from itertools import chain
 
-import six
-
 from ..utils import KNOWN_EXTS, unnest
 from .path import SystemPath
 from .python import PythonVersion
diff --git a/src/pythonfinder/models/mixins.py b/src/pythonfinder/models/mixins.py
index 197a685..3faee14 100644
--- a/src/pythonfinder/models/mixins.py
+++ b/src/pythonfinder/models/mixins.py
@@ -6,7 +6,6 @@
 from collections import defaultdict
 
 import attr
-import six
 
 from ..compat import fs_str
 from ..environment import MYPY_RUNNING
@@ -378,8 +377,7 @@ def find_python_version(
         return next(iter(r[0] for r in results if r is not None), None)
 
 
-@six.add_metaclass(abc.ABCMeta)
-class BaseFinder(object):
+class BaseFinder(object, metaclass=abc.ABCMeta):
     def __init__(self):
         #: Maps executable paths to PathEntries
         from .path import PathEntry
diff --git a/src/pythonfinder/models/path.py b/src/pythonfinder/models/path.py
index 2297dda..555b590 100644
--- a/src/pythonfinder/models/path.py
+++ b/src/pythonfinder/models/path.py
@@ -1,5 +1,4 @@
 # -*- coding=utf-8 -*-
-from __future__ import absolute_import, print_function
 
 import errno
 import operator
@@ -10,7 +9,6 @@
 from itertools import chain
 
 import attr
-import six
 from cached_property import cached_property
 
 from ..compat import Path, fs_str
@@ -740,9 +738,9 @@ def _gen_children(self):
         pass_name = self.name != self.path.name
         pass_args = {"is_root": False, "only_python": self.only_python}
         if pass_name:
-            if self.name is not None and isinstance(self.name, six.string_types):
+            if self.name is not None and isinstance(self.name, str):
                 pass_args["name"] = self.name  # type: ignore
-            elif self.path is not None and isinstance(self.path.name, six.string_types):
+            elif self.path is not None and isinstance(self.path.name, str):
                 pass_args["name"] = self.path.name  # type: ignore
 
         if not self.is_dir:
diff --git a/src/pythonfinder/models/python.py b/src/pythonfinder/models/python.py
index 4a14ff7..3cabca4 100644
--- a/src/pythonfinder/models/python.py
+++ b/src/pythonfinder/models/python.py
@@ -1,5 +1,4 @@
 # -*- coding=utf-8 -*-
-from __future__ import absolute_import, print_function
 
 import logging
 import operator
@@ -9,7 +8,6 @@
 from collections import defaultdict
 
 import attr
-import six
 from packaging.version import Version
 
 from ..compat import Path, lru_cache
@@ -62,7 +60,7 @@ def overload(f):
 
 
 @attr.s(slots=True)
-class PythonFinder(BaseFinder, BasePath):
+class PythonFinder(BasePath, BaseFinder):
     root = attr.ib(default=None, validator=optional_instance_of(Path), type=Path)
     # should come before versions, because its value is used in versions's default initializer.
     #: Whether to ignore any paths which raise exceptions and are not actually python
@@ -133,7 +131,7 @@ def get_version_order(self):
 
     def get_bin_dir(self, base):
         # type: (Union[Path, str]) -> Path
-        if isinstance(base, six.string_types):
+        if isinstance(base, str):
             base = Path(base)
         if os.name == "nt":
             return base
@@ -374,7 +372,7 @@ def __getattribute__(self, key):
             elif self.comes_from:
                 executable = self.comes_from.path.as_posix()
             if executable is not None:
-                if not isinstance(executable, six.string_types):
+                if not isinstance(executable, str):
                     executable = executable.as_posix()
                 instance_dict = self.parse_executable(executable)
                 for k in instance_dict.keys():
@@ -614,7 +612,7 @@ def parse_executable(cls, path):
         result_version = None  # type: Optional[str]
         if path is None:
             raise TypeError("Must pass a valid path to parse.")
-        if not isinstance(path, six.string_types):
+        if not isinstance(path, str):
             path = path.as_posix()
         # if not looks_like_python(path):
         #     raise ValueError("Path %r does not look like a valid python path" % path)
diff --git a/src/pythonfinder/pythonfinder.py b/src/pythonfinder/pythonfinder.py
index 668cd72..3d466ba 100644
--- a/src/pythonfinder/pythonfinder.py
+++ b/src/pythonfinder/pythonfinder.py
@@ -1,12 +1,8 @@
 # -*- coding=utf-8 -*-
-from __future__ import absolute_import, print_function
-
 import importlib
 import operator
 import os
 
-import six
-
 from . import environment
 from .compat import lru_cache
 from .exceptions import InvalidPythonVersion
@@ -97,7 +93,7 @@ def reload_system_path(self):
             self._system_path = self._system_path.clear_caches()
             self._system_path = None
         pyfinder_path = importlib.import_module("pythonfinder.models.path")
-        six.moves.reload_module(pyfinder_path)
+        importlib.reload(pyfinder_path)
         self._system_path = self.create_system_path()
 
     def rehash(self):
@@ -145,7 +141,7 @@ def parse_major(
         # type: (...) -> Dict[str, Union[int, str, bool, None]]
         from .models import PythonVersion
 
-        major_is_str = major and isinstance(major, six.string_types)
+        major_is_str = major and isinstance(major, str)
         is_num = (
             major
             and major_is_str
@@ -252,7 +248,7 @@ def find_python_version(
         }  # type: Dict[str, Union[str, int, Any]]
 
         if (
-            isinstance(major, six.string_types)
+            isinstance(major, str)
             and pre is None
             and minor is None
             and dev is None
@@ -269,7 +265,7 @@ def find_python_version(
             _dev = version_dict.get("is_devrelease", dev)
             dev = bool(_dev) if _dev is not None else dev
             if "architecture" in version_dict and isinstance(
-                version_dict["architecture"], six.string_types
+                version_dict["architecture"], str
             ):
                 arch = version_dict["architecture"]  # type: ignore
         if os.name == "nt" and self.windows_finder is not None:
diff --git a/src/pythonfinder/utils.py b/src/pythonfinder/utils.py
index 091c125..4330e17 100644
--- a/src/pythonfinder/utils.py
+++ b/src/pythonfinder/utils.py
@@ -1,6 +1,4 @@
 # -*- coding=utf-8 -*-
-from __future__ import absolute_import, print_function
-
 import io
 import itertools
 import os
@@ -11,23 +9,13 @@
 from threading import Timer
 
 import attr
-import six
 from packaging.version import LegacyVersion, Version
 
 from .compat import Path, TimeoutError, lru_cache  # noqa
 from .environment import MYPY_RUNNING, PYENV_ROOT, SUBPROCESS_TIMEOUT
 from .exceptions import InvalidPythonVersion
 
-six.add_move(
-    six.MovedAttribute("Iterable", "collections", "collections.abc")
-)  # type: ignore  # noqa
-six.add_move(
-    six.MovedAttribute("Sequence", "collections", "collections.abc")
-)  # type: ignore  # noqa
-# fmt: off
-from six.moves import Iterable  # type: ignore  # noqa  # isort:skip
-from six.moves import Sequence  # type: ignore  # noqa  # isort:skip
-# fmt: on
+from collections.abc import Iterable, Sequence
 
 if MYPY_RUNNING:
     from typing import Any, Callable, Dict, Iterator, List, Optional, Set, Tuple, Union
@@ -332,13 +320,13 @@ def filter_pythons(path):
 def unnest(item):
     # type: (Any) -> Iterable[Any]
     target = None  # type: Optional[Iterable]
-    if isinstance(item, Iterable) and not isinstance(item, six.string_types):
+    if isinstance(item, Iterable) and not isinstance(item, str):
         item, target = itertools.tee(item, 2)
     else:
         target = item
     if getattr(target, "__iter__", None):
         for el in target:
-            if isinstance(el, Iterable) and not isinstance(el, six.string_types):
+            if isinstance(el, Iterable) and not isinstance(el, str):
                 el, el_copy = itertools.tee(el, 2)
                 for sub in unnest(el_copy):
                     yield sub
@@ -384,7 +372,7 @@ def split_version_and_name(
     name=None,  # type: Optional[str]
 ):
     # type: (...) -> Tuple[Optional[Union[str, int]], Optional[Union[str, int]], Optional[Union[str, int]], Optional[str]]  # noqa
-    if isinstance(major, six.string_types) and not minor and not patch:
+    if isinstance(major, str) and not minor and not patch:
         # Only proceed if this is in the format "x.y.z" or similar
         if major.isdigit() or (major.count(".") > 0 and major[0].isdigit()):
             version = major.split(".", 2)
diff --git a/tests/conftest.py b/tests/conftest.py
index 0859b27..8d650b3 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -1,6 +1,7 @@
 # -*- coding=utf-8 -*-
 from __future__ import absolute_import, print_function
 
+import importlib
 import os
 import shutil
 import subprocess
@@ -10,7 +11,6 @@
 import click
 import click.testing
 import pytest
-import six
 
 import pythonfinder
 
@@ -96,8 +96,8 @@ def no_pyenv_root_envvar(monkeypatch):
             m.delenv("PYENV_ROOT")
         if "ASDF_DATA_DIR" in os.environ:
             m.delenv("ASDF_DATA_DIR")
-        six.moves.reload_module(pythonfinder.environment)
-        six.moves.reload_module(pythonfinder.models.path)
+        importlib.reload(pythonfinder.environment)
+        importlib.reload(pythonfinder.models.path)
         m.setattr(pythonfinder.environment, "PYENV_INSTALLED", False)
         m.setattr(pythonfinder.environment, "ASDF_INSTALLED", False)
         m.setattr(pythonfinder.environment, "PYENV_ROOT", normalize_path("~/.pyenv"))
diff --git a/tests/test_python.py b/tests/test_python.py
index bbefedc..0442c67 100644
--- a/tests/test_python.py
+++ b/tests/test_python.py
@@ -2,11 +2,11 @@
 from __future__ import absolute_import, print_function
 
 import functools
+import importlib
 import os
 import sys
 
 import pytest
-import six
 from packaging.version import Version
 
 import pythonfinder
@@ -155,8 +155,8 @@ def test_shims_are_removed(monkeypatch, no_virtual_env, setup_pythons):
     with monkeypatch.context() as m:
         pyenv_dir = pythonfinder.utils.normalize_path("~/.pyenv")
         asdf_dir = pythonfinder.utils.normalize_path("~/.asdf")
-        six.moves.reload_module(pythonfinder.environment)
-        six.moves.reload_module(pythonfinder.models.path)
+        importlib.reload(pythonfinder.environment)
+        importlib.reload(pythonfinder.models.path)
         m.setattr(
             pythonfinder.environment,
             "SHIM_PATHS",
diff --git a/tests/test_utils.py b/tests/test_utils.py
index e020e4a..399b4d3 100644
--- a/tests/test_utils.py
+++ b/tests/test_utils.py
@@ -9,10 +9,7 @@
 import pythonfinder.utils
 from pythonfinder import Finder
 
-if sys.version_info[:2] < (3, 5):
-    from pathlib2 import Path
-else:
-    from pathlib import Path
+from pathlib import Path
 
 os.environ["ANSI_COLORS_DISABLED"] = "1"
 
diff --git a/tests/testutils.py b/tests/testutils.py
index b042596..a861244 100644
--- a/tests/testutils.py
+++ b/tests/testutils.py
@@ -12,12 +12,8 @@
 from contextlib import contextmanager
 
 import click
-import six
 
-if sys.version_info[:2] < (3, 5):
-    from pathlib2 import Path
-else:
-    from pathlib import Path
+from pathlib import Path
 
 
 TRACKED_TEMPORARY_DIRECTORIES = []
@@ -64,8 +60,7 @@ def create_tracked_tempdir(*args, **kwargs):
     tempdir = tempfile.mkdtemp(*args, **kwargs)
     TRACKED_TEMPORARY_DIRECTORIES.append(tempdir)
     atexit.register(shutil.rmtree, tempdir)
-    if six.PY3:
-        warnings.simplefilter("ignore", ResourceWarning)
+    warnings.simplefilter("ignore", ResourceWarning)
     return tempdir
 
 
@@ -114,7 +109,7 @@ def normalize_path(path):
             BUFSIZE = 500
             buffer = create_unicode_buffer(BUFSIZE)
             get_long_path_name = windll.kernel32.GetLongPathNameW
-            get_long_path_name(six.ensure_text(path), buffer, BUFSIZE)
+            get_long_path_name(path.decode(), buffer, BUFSIZE)
             path = buffer.value
         return path