| TAH Drug Code | ISOO |
|---|---|
| Indications | Treatment of infections due to Staph, Strep, pneumococcus, meningococcus & other susceptible organisms such as infections of the upper & lower respiratory tract, GUT, skin & soft tissue, bone & joint. Dental infections, septic abortion, puerperal sepsis, intra-abdominal sepsis. Vial Also indicated for prophylaxis against infection which may be associated with major surgical procedures such as GI, pelvic, head & neck, cardiac, renal, joint replacement & biliary tract. |
| Dosing | Adults and children > 12 years: 1.2 g IV every 6-8 hours for 30-40 minutes; children 3 months to 12 years: 30 mg/kg IV every 6-8 hours; infants 0-3 months: 30 mg/kg IV every 8-12 hours. Surgical prophylaxis: 1.2 g at induction of anesthesia then 1.2 g 3-4 times within 24 hours. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Hypersensitivity to penicillins, possible cross sensitivity with other β-lactam antibiotics. History of penicillin-associated cholestatic jaundice/hepatic dysfunction |
| Adverse Effects | Common: Diaper rash (3.5-6%), Rash (1.1-3%), Urticaria, Diarrhea (2.9-14.5%), Loose stool (1.6-9%), Nausea (up to 3%), Vomiting (up to 2.2%), Mycosis (3.3%), Vaginitis (1%), Candidiasis (1.4%) Serious: Drug reaction with eosinophilia and systemic symptoms, Generalized exanthematous pustulosis, acute, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Clostridium difficile diarrhea, Cholestasis, Hepatitis, Hepatotoxicity, Anaphylaxis, Hypersensitivity reaction, Angioedema, Serum sickness due to drug |
| Pregnancy | Human Data Suggest Low Risk |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |
| TAH Drug Code | LSOO |
|---|---|
| Indications | Treatment of infections due to Staph, Strep, pneumococcus, meningococcus & other susceptible organisms such as infections of the upper & lower respiratory tract, GUT, skin & soft tissue, bone & joint. Dental infections, septic abortion, puerperal sepsis, intra-abdominal sepsis. Vial Also indicated for prophylaxis against infection which may be associated with major surgical procedures such as GI, pelvic, head & neck, cardiac, renal, joint replacement & biliary tract. |
| Dosing | (Each mL contain: Amoxicillin 25mg + Clavulanic Acid 6.25mg) Immediate-release formulations: Infants, Children, and Adolescents: 4:1 formulation: Oral 20-40 mg amoxicillin/kg/day divided into q8h. Maximum 1500 mg/day. Children aged 7-12 years: 10-20 mL TID. Children aged 2-7 years: 5-10 mL TID. Children aged 9 months to 2 years: 2.5-5 mL TID. Children aged 0-9 months: No oral dosage form suitable for this age group available. Do not exceed 14 days without reevaluation. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | History of allergy to amoxicillin, other penicillins, or clavulanic acid. History of allergy to other β-lactam antibiotics, such as cephalosporins. History of jaundice or impaired liver function due to previous use of this medication or penicillin. |
| Adverse Effects | Common: Diaper rash (3.5-6%), Rash (1.1-3%), Urticaria, Diarrhea (2.9-14.5%), Loose stool (1.6-9%), Nausea (up to 3%), Vomiting (up to 2.2%), Mycosis (3.3%), Vaginitis (1%), Candidiasis (1.4%) Serious: Drug reaction with eosinophilia and systemic symptoms, Generalized exanthematous pustulosis, acute, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Clostridium difficile diarrhea, Cholestasis, Hepatitis, Hepatotoxicity, Anaphylaxis, Hypersensitivity reaction, Angioedema, Serum sickness caused by drug |
| Pregnancy | Human Data Suggest Low Risk |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |
| TAH Drug Code | OCUR |
|---|---|
| Indications | Treatment of infections due to Staph, Strep, pneumococcus, meningococcus & other susceptible organisms such as infections of the upper & lower respiratory tract, GUT, skin & soft tissue, bone & joint. Dental infections, septic abortion, puerperal sepsis, intra-abdominal sepsis. |
| Dosing | Adults and children > 12 years: Curam 1000 mg orally twice daily. Swallow whole tablets or in half. Curam 1000 mg is not recommended for children younger than 12 years. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | History of hypersensitivity to β-lactams. History of penicillin-associated jaundice/hepatic dysfunction. |
| Adverse Effects | Common: Diaper rash (3.5-6%), Rash (1.1-3%), Urticaria, Diarrhea (2.9-14.5%), Loose stool (1.6-9%), Nausea (up to 3%), Vomiting (up to 2.2%), Mycosis (3.3%), Vaginitis (1%), Candidiasis (1.4%) Serious: Drug reaction with eosinophilia and systemic symptoms, Generalized exanthematous pustulosis, acute, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Clostridium difficile diarrhea, Cholestasis, Hepatitis, Hepatotoxicity, Anaphylaxis, Hypersensitivity reaction, Angioedema, Serum sickness due to drug |
| Pregnancy | Human Data Suggest Low Risk |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |