| TAH Drug Code | IAMPI |
|---|---|
| Indications | Bacterial meningitis, Gonorrhea, Infectious disease of digestive tract, Infectious disease of genitourinary system, Infective endocarditis, Respiratory tract infection, Sepsis. |
| Dosing | Usually, adults: 250-500 mg IM 2-4 times daily, children weighing < 20 kg: 25-60 mg/kg/day IM/IV in 3-4 divided doses. Infection of respiratory tract, skin or soft tissue and genitourinary tract: adults 250-500 mg every 6 hours; children weighing < 40 kg: 25-50 mg/kg/day in 4 divided doses. Urinary tract infection due to N. Gonorrhea: adults 500 mg every 12 hours. Bacterial meningitis: adults 8-14 g/day; children 100-200 mg/kg/day. Administer in equally divided doses every 3-4 hours. Treatment may be initiated with intravenous drip therapy and continued with intramuscular injections. NEONATE ANTIBIOTICS DOSE Ampicillin: Total dose: General infection: 100 mg/kg/day Group B streptococcal bacteremia (GBS) sepsis: 200mg/kg/day PMA (postmenstrual age) = gestational age + postnatal age Drug Interval: PMA <=29 week Postnatal 0-28 days Q12H PMA <=29 week Postnatal >= 29 days Q8H PMA 30 to 36 week Postnatal 0-14 days Q12H PMA 30 to 36 week Postnatal >=15 days Q8H PMA 37 to 44 week Postnatal 0-7 days Q12H PMA 37 to 44 week Postnatal >= 8 days Q8H PMA >=45 week Q6H GBS meningitis: Total dose 0-7 days: 200 to 300 mg/kg/day divided Q8H 8 days and older: 300 mg/kg/day divided Q6H |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Hypersensitivity to any penicillin. |
| Adverse Effects | Common: Rash, Urticaria, Diarrhea. Serious: Erythema multiforme, Erythroderma, Toxic epidermal necrolysis, Clostridium difficile colitis, Agranulocytosis, Thrombocytopenia, Anaphylaxis. |
| Pregnancy | No (Limited) Human Data – Animal Data Suggest Low Risk |
| Lactation | Compatible |
| More Info | UpToDate |