cefixime.md

Cefixime

CEXime 100mg

TAH Drug Code	OCEX
Indications	Streptococcus VSS S. pneumoniae, N. gonorrhoeae, Branhamella catarrhalis, E. coli, Klebsiella VSS Serratia VSS Proteus VSS H. Influenzae, the following infection caused by Cefixime susceptibility: bronchitis, bronchiectasis (infection), secondary infection of chronic respiratory diseases, pneumonia, pyelonephritis, cystitis, bacterial urethritis, otitis media, sinusitis.
Dosing	Adults and children > 30 kg: 50-100 mg orally twice daily; 200 mg twice daily for serious infection. [Sanford Guide to Antimicrobial Therapy 2021] Pediatric dose: Age > 28days: 8 mg/kg/day, divided Q12-24H.
Hepatic Impairment	Dose adjustment not necessary
Renal Impairment	Dose adjustment required
Contraindications	Hypersensitivity to cefixime, any component of the formulation, or other cephalosporins or penicillins
Adverse Effects	>10%: Gastrointestinal: Diarrhea (16%) 2% to 10%: Gastrointestinal: Abdominal pain, nausea, dyspepsia, flatulence, loose stools <2%: Acute renal failure, anaphylactoid reaction, anaphylaxis, angioedema, candidiasis, dizziness, drug fever, eosinophilia, erythema multiforme, facial edema, fever, headache, hepatitis, hyperbilirubinemia, increased blood urea nitrogen, increased serum creatinine, increased serum transaminases, jaundice, leukopenia, neutropenia, prolonged prothrombin time, pruritus, pseudomembranous colitis, seizure, serum sickness-like reaction, skin rash, Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, urticaria, vaginitis, vomitingy.
Pregnancy	Compatible
Lactation	Compatible
More Info	UpToDate