| TAH Drug Code | ICLA1 |
|---|---|
| Indications | Respiratory tract, ENT, skin & soft tissue, bone & joints, genital organs, abdominal infections, UTI; septicemia, endocarditis, meningitis. |
| Dosing | Adults and children > 50 kg: 1-2 g IV/IM Q8-12H; serious infection: 2 g IV Q6-8H (maximum 12 g/day); gonorrhea: 0.5-1 g IM as single dose. Children < 50 kg: 50-100 mg/kg/day IV/IM (divided Q6-12H); 150-200 mg/kg/day for severe infections. Preterm infants: 50 mg/kg/day (divided Q12H). NEONATE ANTIBIOTICS DOSE Cefotaxime (Claforan): General infection: total dose : 100-150 mg/kg/day Body weight <1kg ge<=7day 50mg/kg Q12H Age 8-14 day 0mg/kg Q12H Age 15-28 day 0 mg/kg Q8H Body weight 1-2kg ge<=7day 0mg/kg Q12H Age 8-14 day 50 mg/kg Q8H Age 15-28 day 50 mg/kg Q8H Body weight >2kg Age<=7day 50 mg/kg Q12H Age 8-14 day 50 mg/kg Q8H Age 15-28 day 50mg/kg Q8H meningitis; total dose : 200 mg/kg/day ; interval 比照上述表格所示 (參考馬偕)。 Neofax: But if Body weight <2kg Age<=7days total dose : 100-150mg/kg/day Q12-Q8H Age 8-28 days total dose: 150-200mg/kg/day Q8H-Q6H |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Hypersensitivity to cephalosporins. |
| Adverse Effects | Thrombocytopenia, eosinophilia, leukopenia; hypersensitivity reactions; GI effects; anaphylactic shock (rare). Dermatologic: Injection site pain, Injection site phlebitis, Rash (2.2% ) Gastrointestinal: Diarrhea, Vomiting |
| Pregnancy | Compatible |
| Lactation | Compatible |
| More Info | UpToDate |