| TAH Drug Code | IACE |
|---|---|
| Indications | Respiratory tract infection, UTI, bacteremia, septicemia, skin & soft tissue infection, intra-abdominal, burns, post-op infection. |
| Dosing | Adults and children: 7.5-15 mg/kg/day divided into 2 doses infused over 30-60 minutes; neonates and premature infants: 10-15 mg/kg/day divided into 2 doses infused over 1-2 hours. For adults with life-threatening infections: 500 mg every 8 hours (Maximum dose 1.5 g/day; duration < or = 10 days). Amikacin in concentrations 0.25% (2.5 mg/ml) may be used as an irrigating solution in abscess cavities, the pleural space, the peritoneum (adults: 0.5 g/dose) and the cerebral ventricles. Intraventricular injection: 1-5 mg/day in concentrations 1 mg/mL for 3 days. NEONATE ANTIBIOTICS DOSE Amikacin: Draw peak 30 min after completion infusion; draw trough just before next dose (於第4個dose給藥前) PMA <=29 week Postnatal 0 to 7 days dose : 18mg/kg Q48h PMA <=29 week Postnatal 8 to 28 days dose : 15mg/kg Q36 h PMA <=29 week Postnatal >=29 days dose :15mg/kg Q24 h PMA 30 – 34 week Postnatal 0 to 7 days dose : 18mg/kg Q36 h PMA 30 – 34 week Postnatal >= 8 days dose : 15mg/kg Q24 h PMA 35 - 44 week , dose : 15mg/kg Q24 h |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Hypersensitivity to aminoglycosides. Pregnancy. Myasthenia gravis |
| Adverse Effects | Frequency not defined: Neurotoxicity (including muscle twitching, numbness, seizure, tingling of skin), Auditory ototoxicity, vestibular ototoxicity, Nephrotoxicity, Respiratory paralysis. Postmarketing: Hypotension, Skin rash, Albuminuria, hypomagnesemia, Clostridium difficile-associated diarrhea, nausea, vomiting, Azotemia, hematuria, oliguria, toxic nephrosis, Anemia, eosinophilia, leukocyturia, Drug reaction with eosinophilia and systemic symptoms, Drug fever, headache, paresthesia, tremor, Arthralgia, state of neuromuscular blockade, Acute kidney injury, casts in urine, increased serum creatinine. |
| Pregnancy | Human Data Suggest Low Risk |
| Lactation | Compatible |
| More Info | UpToDate |