| TAH Drug Code | ITAR |
|---|---|
| Indications | Infective endocarditis, osteomyelitis, pneumonia, sepsis, soft tissue infections, enteritis, and pseudomembranous colitis caused by Staphylococcus aureus infection. Teicoplanin is suitable for severe infections caused by Gram-positive bacteria, including those that cannot be treated with antibiotics such as penicillin and cephalosporins. Teicoplanin is suitable for severe Staphylococcus aureus infections that cannot be treated with penicillin and cephalosporins, or in cases of treatment failure, or when resistance to other antibiotics has developed. Teicoplanin is effective for infections of the skin and soft tissue, urinary tract, lower respiratory tract, joints and bones, sepsis, endocarditis, and peritonitis caused by continuous ambulatory peritoneal dialysis. |
| Dosing | Adult: 6 mg/kg Q12H x 3 IV/IM doses (target trough: >15 μg/mL), then 6 mg/kg IV/IM once daily (target trough: >15 μg/mL). Bone and joint infection: 12 mg/kg IV Q12H x 3-5 doses (target trough: >20 μg/mL), then 12 mg/kg IV/IM Q24H (target trough: >20 μg/mL). Endocarditis: 12 mg/kg IV Q12H x 3-5 doses (target trough: 30-40 μg/mL), then 12 mg/kg IV/IM Q24H (target trough: >30 μg/mL); a total treatment duration 21 days is recommended. Pediatric: Age 0 to <=2 months: 16mg/kg IVD x 1 dose on Day 1, then 8mg/kg IVD q24h since Day 2 Age 2 months to 16 years: 10mg/kg IV q12h x 3 doses, then 6-10mg/kg IV/IM q24h NOTE: Target trough should measured by FPIA (Fluorescence Polarization Immunoassay). After loading dose, trough should be measured at day 3-5; during maintenance dose, trough should be measured weekly. NEONATE ANTIBIOTICS DOSE Teicoplanin (Targocid): loading dose 16 mg/kg/dose, followed by 8 mg/kg/dose QD |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Hypersensitivity to teicoplanin or any component of the product. |
| Adverse Effects | Common: Local pain, Nausea, Dizziness, Headache, Eosinophilia, Leukopenia, Erythema, Pruritus, Rash (1-<10%), Fever (1-<10%). Serious: Stevens-Johnson syndrome, Toxic epidermal necrolysis, Thrombocytopenia (0.1-<1%), Anaphylaxis (0.1-<1%), Hypersensitivity reaction, Toxic deafness (0.1-<1%), Renal failure. |
| Pregnancy | Unknown |
| Lactation | Unknown |
| More Info | UpToDate |