| TAH Drug Code | EVORS |
|---|---|
| Indications | Rheumatism, acute musculoskeletal disorders, post-traumatic & post-op inflammation & swelling. |
| Dosing | Adult: 75-100mg/day in 2 or 3 divided doses. Children >1year old: 0.5-2mg/kg/day in 2 or 3 divided doses. Juvenile rheumatoid arthritis(JRA) can increase to 3 mg/kg/day in divided doses. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Patients sensitive to aspirin or other NSAIDs. |
| Adverse Effects | GI disturbances. Peptic ulceration. GI bleeding. Headache, dizziness, nervousness, skin rash, pruritus, tinnitus, edema, depression, drowsiness, insomnia, & blurred vision. Hypersensitivity. Impairment of liver & kidney function. Agranulocytosis & thrombopenia. Dermatologic: Application site reaction (gel: all reactions, 7%; dermatitis, 4% to 11% ) Hematologic: Blood coagulation disorder (1% to 10% ) Ophthalmic: Burning sensation in eye (15% ), Keratitis (up to 28% ), Lacrimation and lacrimal drainage - finding (up to 30% ), Raised intraocular pressure (up to 15% ) |
| Pregnancy | Human Data Suggest Risk in 1st and 3rd Trimesters |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |
| TAH Drug Code | IVOR |
|---|---|
| Indications | Rheumatism, acute musculoskeletal disorders, post-traumatic & post-op inflammation & swelling. |
| Dosing | Adults: 75 mg(1 ampoule) IM once a day. Slow injection deep into the lateral buttock muscles. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Patients sensitive to aspirin or other NSAIDs. |
| Adverse Effects | GI disturbances. Peptic ulceration. GI bleeding. Headache, dizziness, nervousness, skin rash, pruritus, tinnitus, edema, depression, drowsiness, insomnia, & blurred vision. Hypersensitivity. Impairment of liver & kidney function. Agranulocytosis & thrombopenia. Dermatologic: Application site reaction (gel: all reactions, 7%; dermatitis, 4% to 11% ) Hematologic: Blood coagulation disorder (1% to 10% ) Ophthalmic: Burning sensation in eye (15% ), Keratitis (up to 28% ), Lacrimation and lacrimal drainage - finding (up to 30% ), Raised intraocular pressure (up to 15% ) |
| Pregnancy | Human Data Suggest Risk in 1st and 3rd Trimesters |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |
| TAH Drug Code | OCAT2 |
|---|---|
| Indications | Relief of pain & inflammation in RA, osteoarthritis, ankylosing spondylitis, migraine attacks, low back pain, painful syndromes of the vertebral column, non-articular rheumatism, painful post-traumatic & post-op inflammation. |
| Dosing | >14 years old: 75-100mg/day in 2-3 divided doses. Children: Recommend drops or suppositories for treatment. Elders: Treat with caution. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Peptic ulcer; known hypersensitivity to diclofenac or other NSAIDs; patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by aspirin or other NSAIDs. |
| Adverse Effects | Epigastric pain, nausea, vomiting, diarrhea, abdominal cramps, dyspepsia, flatulence, anorexia, headache, dizziness, vertigo, rashes or skin eruptions, elevation of serum aminotransferase. Rarely, GI bleeding, fatigue, urticaria, gastric or intestinal ulcer, drowsiness, edema, hepatitis with or without jaundice. Dermatologic: Application site reaction (gel: all reactions, 7%; dermatitis, 4% to 11% ) Hematologic: Blood coagulation disorder (1% to 10% ) Ophthalmic: Burning sensation in eye (15% ), Keratitis (up to 28% ), Lacrimation and lacrimal drainage - finding (up to 30% ), Raised intraocular pressure (up to 15% ) |
| Pregnancy | Human Data Suggest Risk in 1st and 3rd Trimesters |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |
| TAH Drug Code | ODIC1 |
|---|---|
| Indications | Rheumatism, acute musculoskeletal disorders, post-traumatic & post-op inflammation & swelling. |
| Dosing | 100 mg QD, swallowed whole |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Patients sensitive to aspirin or other NSAIDs. |
| Adverse Effects | GI disturbances. Peptic ulceration. GI bleeding. Headache, dizziness, nervousness, skin rash, pruritus, tinnitus, edema, depression, drowsiness, insomnia, & blurred vision. Hypersensitivity. Impairment of liver & kidney function. Agranulocytosis & thrombopenia. Dermatologic: Application site reaction (gel: all reactions, 7%; dermatitis, 4% to 11% ) Hematologic: Blood coagulation disorder (1% to 10% ) Ophthalmic: Burning sensation in eye (15% ), Keratitis (up to 28% ), Lacrimation and lacrimal drainage - finding (up to 30% ), Raised intraocular pressure (up to 15% ) |
| Pregnancy | Human Data Suggest Risk in 1st and 3rd Trimesters |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |