| TAH Drug Code | OLON |
|---|---|
| Indications | Osteoarthritis. Pain. Rheumatoid arthritis. |
| Dosing | Pain: 200 to 400 mg orally every 6 to 8 hours; maximum 1200 mg/day. Rheumatoid arthritis or osteoarthritis: 300 mg orally BID to TID; or 500mg BID |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Asthma, urticaria, or allergic-type reaction following aspirin or other NSAID administration; severe, even fatal anaphylactic-like reactions have been reported. hypersensitivity to etodolac. CABG surgery within 14 days, treatment of perioperative pain. |
| Adverse Effects | Common Cardiovascular: Edema (1% to 10% ) Gastrointestinal: Abdominal pain (3% to 9% ), Diarrhea (3% to 9% ), Flatulence (3% to 9% ), Indigestion (10% ), Nausea (3% to 9% ) Hepatic: Increased liver function test (up to 15% ) Neurologic: Dizziness (3% to 9% ), Headache (3% to 4% ) Other: Malaise (3% to 9% ) Serious Cardiovascular: Congestive heart failure (less than 1% ), Hypertension (less than 1% ), Myocardial infarction (less than 1% ), Thrombotic tendency observations Dermatologic: Erythroderma, Stevens-Johnson syndrome (less than 1% ), Toxic epidermal necrolysis (less than 1% ) Gastrointestinal: Gastrointestinal hemorrhage, Gastrointestinal perforation, Gastrointestinal ulcer, Inflammatory disorder of digestive tract Hematologic: Thrombocytopenia (less than 1% ) Hepatic: Hepatic necrosis, Hepatitis (less than 1% ), Liver failure (less than 1% ) Immunologic: Anaphylactoid reaction (less than 1% ) Neurologic: Cerebrovascular accident Renal: Acute renal failure (less than 1% ), Papillary necrosis (less than 1% ) Respiratory: Bronchospasm |
| Pregnancy | Human Data Suggest Risk in 1st and 3rd Trimesters |
| Lactation | No (Limited) Human Data - Potential Toxicity |
| More Info | UpToDate |