| TAH Drug Code | ILATO |
|---|---|
| Indications | Short-term (<=5 days) use for relieving moderate to severe acute pain in patients unable to take orally, typically post-surgery |
| Dosing | Not recommended for children. Single Dose Therapy: (1) Intramuscular Injection: <65 years: 60mg/dose; >=65 years, renal insufficiency, body weight <50kg: 30mg/dose. (2) Intravenous Injection: <65 years: 30mg/dose; >=65 years, renal insufficiency, body weight <50kg: 15mg/dose. Repeat Dosing Regimen (Intravenous or Intramuscular Injection): <65 years: 30mg q6h (maximum 120mg/day); >=65 years, renal insufficiency, body weight <50kg: 15mg q6h (maximum 60mg/day) |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | 1. Allergic history to this medication. 2. History of allergy due to Aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). 3. Prohibited within 14 days after Coronary Artery Bypass Graft (CABG) surgery. |
| Adverse Effects | Common: Edema (1-10%), Hypertension (1-10%), Injection site pain (injection, 1-10%), Pruritus (1-10%), Rash (1-10%), Sweating (1-10%), Abdominal pain (1-10%), Constipation, Diarrhea, Flatulence (1-10%), Heartburn (1-10%), Indigestion (1-10%), Nausea (greater than 10%), Stomatitis (1-10%), Vomiting (1-10%), Anemia (1-10%), Purpuric disorder (1-10%), Dizziness (1-10%), Headache (greater than 10%), Somnolence (1-10%), Burning sensation in eye (20-40%), Corneal edema (1-10%), Eye infection (1-10%), Eye irritation (1-10%), Iritis (1-10%), Pain in eye (1-10%), Superficial keratitis (1-10%), Nasal irritation (15%), Pain of nose (13%) Serious: Myocardial infarction, Thrombotic tendency observations, Erythroderma, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Gastrointestinal hemorrhage (1-10%), Gastrointestinal perforation, Gastrointestinal ulcer (1-10%), Melena (<1%), Blood coagulation disorder with prolonged bleeding time (1-10%), Hematoma, Hemorrhage, Postoperative hemorrhage, Hepatitis (<1%), Hepatotoxicity, Increased liver function test (1-10%), Jaundice (<1%), Non-allergic anaphylaxis, Cerebrovascular accident, Corneal thinning, Perforation of cornea, Hearing loss (<1%), Injury of kidney, Nephrotic syndrome, Renal failure (<1%), Tubulointerstitial nephritis (<1%), Bronchospasm, Dyspnea (<1%), Pulmonary edema (<1%) |
| Pregnancy | Human Data Suggest Risk in 1st and 3rd Trimesters |
| Lactation | Contraindicated |
| More Info | UpToDate |
| TAH Drug Code | OKET |
|---|---|
| Indications | For the short-term management of moderate-severe acute pain, including pain following major abdominal, orthopedic & gynecological operative procedures. |
| Dosing | 10mg(1 capsule) every 4-6 hours |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Hypersensitivity to aspirin or other NSAIDs. |
| Adverse Effects | Nausea, abdominal discomfort, peptic ulceration, GI bleeding, drowsiness, dizziness. Cardiovascular: Edema (1% to 10% ), Hypertension (1% to 10% ) Dermatologic: Injection site pain (injection, 1% to 10% ), Pruritus (1% to 10% ), Rash (1% to 10% ), Sweating (1% to 10% ) Gastrointestinal: Abdominal pain (1% to 10% ), Diarrhea, Indigestion (1% to 10% ), Nausea (greater than 10% ) Hematologic: Anemia (1% to 10% ), Purpura (1% to 10% ) Neurologic: Dizziness (1% to 10% ), Headache (greater than 10% ), Somnolence (1% to 10% ) Ophthalmic: Burning sensation in eye, Transient (ophthalmic, 20% to 40% ), Corneal edema (ophthalmic, 1% to 10% ), Eye irritation (ophthalmic, 1% to 10% ), Iritis (ophthalmic, 1% to 10% ), Keratitis (ophthalmic, 1% to 10% ) Respiratory: Nasal irritation (nasal, 15% ), Pain, Rhinalgia (nasal, 13% ) |
| Pregnancy | Human Data Suggest Risk in 1st and 3rd Trimesters |
| Lactation | Contraindicated |
| More Info | UpToDate |