| TAH Drug Code | OZOL |
|---|---|
| Indications | Depression, obsessive-compulsive disorder (OCD), panic disorder, post traumatic stress disorder (PTSD), social phobia, premenstrual dysphoric disorder (PMDD). |
| Dosing | 50-200 mg daily. Dosage may be increased in 50 mg increments to maximum 200 mg over a period of weeks. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Patients with known hypersensitivity to sertraline. Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs). |
| Adverse Effects | Nausea, diarrhoea/loose stools, anorexia, dyspepsia; male sexual dysfunction (ejaculatory delay); tremor; dry mouth; increased sweating. Sertraline has been associated with PALPITATIONS, CHEST PAIN, HYPERTENSION, HYPOTENSION, EDEMA, SYNCOPE, and TACHYCARDIA |
| Pregnancy | Human Data Suggest Risk in 3rd Trimester |
| Lactation | No (Limited) Human Data - Potential Toxicity |
| More Info | UpToDate |