| TAH Drug Code | ICIT3 |
|---|---|
| Indications | Anaesth for diagnostic & surgical procedures; induction of anaesth or to supplement low potency agent |
| Dosing | Use 2.5% solution for IV injection. Induction of general anesthesia: 50-100mg (2.5% solution, 2-4 mL) Anesthesia of short duration: 50-75mg (2.5% solution, 2-3mL) IV over 10-15 seconds initially, monitor the reaction for 30 seconds, if necessary, may readminister 50-75mg to produce anesthesia state. For maintaining the depth of anesthesia when the operation is not completed, give 25-100mg (2.5% solution, 1-4 mL). Maximum: 1000 mg for each time. Anesthesia for psychological electroconvulsive therapy: 300mg over 25-35 seconds (2.5% solution, 12 mL). Combine use with local or inhaled anesthetics: 50-100mg IV drip intermittently (2.5% solution, 2-4mL). Seizure: 50-200mg IV slowly (2.5% solution, 2-8mL). |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Shock & circulatory insufficiency due to severe hemorrhage, severe cardiac insufficiency, acute & intermittent porphyria, Addison's disease, severe bronchial asthma. Hypersensitivity to barbiturates. |
| Adverse Effects | During anesth: respiratory arrest or depression, laryngospasm, hypotensin, arrhythmia, rash. After anesth: nausea, vomiting, headache, dizziness, tearing eyes, tremor, spasm, excitation, face flush, diplopia, numbness, urinary retention, drowsiness. |
| Pregnancy | Unknown |
| Lactation | Unknown |
| More Info | UpToDate |