| TAH Drug Code | OBOW |
|---|---|
| Indications | Bowel cleansing prior to colonoscopy |
| Dosing | First sachet in 150 mL water, in the evening before the colonoscopy (5 PM-9 PM), (After taking the medicine, replenish 250mL clear liquid drink at least 5 times before going to bed, and drink it within 5 hours). Followed by the second sachet in 150 mL water (5 oz) ~5 hours before the colonoscopy. (After taking the second dose , replenish 250mL clear liquid drink at least 3 times , and drink it before the colonoscopy 2 hours.) |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Hypersensitivity to sodium picosulfate, magnesium oxide, anhydrous citric acid, or any component of the formulation; GI obstruction or ileus; bowel perforation; gastric retention; toxic colitis; toxic megacolon; severe renal impairment (CrCl <30 mL/minute). |
| Adverse Effects | >10%: Endocrine & metabolic: Hypermagnesemia (9% to 12%) Genitourinary: Decreased estimated GFR (eGFR; ?48 hours after colonoscopy: 10% to 29%) 1% to 10%: Central nervous system: Headache (2% to 3%) Endocrine & metabolic: Hypokalemia (5% to 7%), hypochloremia (1% to 4%), hyponatremia (1% to 4%) Gastrointestinal: Nausea (3%), vomiting (1%) Renal: Increased serum creatinine (5%) <1% (Limited to important or life-threatening): Hypersensitivity reaction, ischemic colitis, seizure, ulcer (aphthoid ileal) |
| Pregnancy | Unknown |
| Lactation | Unknown |
| More Info | UpToDate |