| TAH Drug Code | OPLET1 |
|---|---|
| Indications | Reduction of symptoms of intermittent claudication, as indicated by an increased walking distance. |
| Dosing | Oral 100mg twice daily. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Patients with CHF of any severity. |
| Adverse Effects | Abdominal pain, back pain, headache, infection, palpitation, tachycardia, GI effects, peripheral edema, myalgia, dizziness, vertigo, cough, pharyngitis, rhinitis. Cardiovascular: Palpitations (5% to 10% ), Peripheral edema (7% to 9% ), Tachyarrhythmia (4% ) Gastrointestinal: Abdominal pain (4% to 5% ), Diarrhea (12% to 19% ), Feces contents abnormal (12% to 15% ), Indigestion (6% ) Hematologic: Decreased platelet aggregation Musculoskeletal: Backache (6% to 7% ), Myalgia (2% to 3% ) Neurologic: Dizziness (9% to 10% ), Headache (27% to 34% ) Respiratory: Increasing frequency of cough (3% to 4% ), Pharyngitis (7% to 12% ), Rhinitis (7% to 12% ) Other: Infectious disease (10% to 14% ) |
| Pregnancy | No (Limited) Human Data – Animal Data Suggest Risk |
| Lactation | No (Limited) Human Data - Potential Toxicity |
| More Info | UpToDate |