| TAH Drug Code | OCLOPD |
|---|---|
| Indications | Prevention of atherothrombotic events in patients suffering from MI, ischemic stroke or established peripheral arterial disease; in patients suffering from non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave MI) in combination with aspirin. ST segment elevation acute MI in combination with aspirin in patients eligible for thrombolytic therapy. |
| Dosing | Adult & elderly recommend 75 mg once daily. Patients with non-ST segment elevation acute coronary syndrome: Initially giving 300 mg as loading dose, continued with 75 mg once daily (combined with 75-325 mg aspirin daily). Dose of aspirin should be less than 100 mg. ST segment elevation acute MI: 75 mg daily, combined with aspirin. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Severe liver impairment. Peptic ulcer & intracranial haemorrhage. Lactation. |
| Adverse Effects | GI bleeding, purpura, bruising, haematoma, epistaxis, haematuria, ocular haemorrhage, intracranial bleeding, abdominal pain, dyspepsia, gastritis & diarrhoea, rash, pruritus. Cardiovascular: Chest pain, Hypertension (4.3% ) Dermatologic: Pruritus (3.3% ), Purpuric disorder (5.3% ), Rash (4.2% ) Endocrine metabolic: Hypercholesterolemia Gastrointestinal: Abdominal pain, Constipation, Diarrhea, Gastritis, Indigestion Hematologic: Epistaxis (2.9% ), Purpura (5.3% ) Musculoskeletal: Arthralgia (6.3% ), Backache (5.8% ) Neurologic: Headache (7.6% ) |
| Pregnancy | No (Limited) Human Data – Probably Compatible |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |