| TAH Drug Code | INOV1 |
|---|---|
| Indications | Treatment of bleeding episodes & prevention of excessive bleeding in those undergoing surgery or invasive procedure in patients with congenital hemophilia with inhibitors, acquired hemophilia, Factor VII (FVII) deficiency, Glanzmann's thrombathenia. |
| Dosing | 1.Hemophilia with inhibitors or acquired hemophilia or severe bleeding: 90 mcg/kg 2-3 hourly as single IV bolus. May increase dosing frequency to 4, 6, 8 or 12 hourly. One single injection of 270 μg/kg body can be given to hemophilia patients with mild to moderate bleeding episodes. 2.FVII deficiency: 15-30 mcg/kg 4-6 hourly by IV bolus. 3.Glanzmann's thrombasthenia: 90 mcg/kg body weight (80-120 mcg/kg body weight ) 2 hourly (1.5-2.5 hr) at least 3 doses.4.off-labeled use:Post-partum haemorrhage (PPH) unresponsive to standard therapy: 90 mcg/kg assingle IV bolus (over 2-5 min). At 20 min if no response, check and optimise: temperature; acidemia; serum calcium; platelets, fibrinogen. May consider administer a second dose of 90 mcg/kg. Australian and New Zealand Journal of Obstetrics and Gynaecology 2008; 48: 12–16 |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Hypersensitivity to mouse, hamsters or bovine protein. |
| Adverse Effects | Rarely rash, itching, fever, nausea, headache, general discomfort, perspiration or changes in BP. |
| Pregnancy | Unknown |
| Lactation | Unknown |
| More Info | UpToDate |