dienogest.md

Dienogest

Visanne 2mg

TAH Drug Code	OVIS2
Indications	Management of pelvic pain associated with endometriosis.
Dosing	1 tablet once daily.
Hepatic Impairment	Dose adjustment not necessary
Renal Impairment	Dose adjustment not necessary
Contraindications	Hypersensitivity to dienogest or any component of the formulation; undiagnosed abnormal vaginal bleeding; active venous thromboembolic disorder; history of or current arterial and cardiovascular disease (eg, MI, ischemic heart disease, cerebrovascular accident); diabetes mellitus with vascular involvement; history of or current severe hepatic disease where liver function tests remain abnormal; history of or current hepatic neoplasia (benign or malignant); known or suspected sex-hormone-dependent malignancy; ocular lesions due to ophthalmic vascular disease, such as partial or complete vision loss or defect in visual fields; current or history of migraine with focal aura; breast-feeding; known or suspected pregnancy.
Adverse Effects	1% to 10%: Central nervous system: Headache (7%), depression (3%), disturbed sleep (2%), irritability (1%), migraine (1%), nervousness (1%) Dermatologic: Acne vulgaris (2%), alopecia (1%) Endocrine & metabolic: Breast changes (discomfort: 5%), weight gain (4%), ovarian cyst (3%), decreased libido (2%) Gastrointestinal: Nausea (4%), abdominal pain (2%) Genitourinary: Vaginal hemorrhage (1%) Neuromuscular & skeletal: Weakness (2%) <1%, postmarketing, and/or case reports: Abdominal distress, anemia, anxiety, back pain, breast induration, constipation, decreased glucose tolerance, dermatitis, diarrhea, disturbance in attention, dysautonomia, edema, feeling of heaviness (extremities), fibrocystic breast disease, flatulence, genital discharge, GI inflammation, hot flash, increased appetite, limb pain, lump in breast, mood changes, muscle spasm, onychoclasis, ostealgia, palpitations, pelvic pain, pruritus, skin pigmentation, skin photosensitivity, tinnitus, urinary tract infection, vulvovaginal candidiasis, vomiting, vulvar dryness, xeroderma, xerophthalmia.
Pregnancy	Unknown
Lactation	Unknown
More Info	UpToDate