| TAH Drug Code | ILUMI |
|---|---|
| Indications | Moderate to severe plaque psoriasis, pustular psoriasis. |
| Dosing | SC, 210 mg at weeks 0, 1, and 2, followed by 210 mg once every 2 weeks. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Crohn disease, Clinically significant hypersensitivity to brodalumab or any component of the formulation. |
| Adverse Effects | Common: Diarrhea (2.2%), Infectious disease (25.4%), Mycosis (1.8-2.4%), Arthralgia (4.7%), Headache (4.3%), Pain in throat (2.1%), Fatigue (2.6%) Serious: Neutropenia, Grade 3 or greater (0.5%), Cryptococcal meningitis, Suicidal thoughts, Suicide |
| Pregnancy | No (Limited) Human Data – Animal Data Suggest Low Risk |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |