| TAH Drug Code | OGLUC |
|---|---|
| Indications | Type 2 diabetes mellitus |
| Dosing | According to the individual needs of the patient, maximum 3000 mg/day.Contrast media, history of liver disease, alcoholism, or heart failure, patient receiving intraarterial administration of iodinated contrast: Discontinue at time of or before procedure; evaluate eGFR 48 hours after imaging procedure; restart if renal function stable. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment required |
| Contraindications | Acute or chronic metabolic acidosis including diabetic ketoacidosis with or without coma. Hypersensitivity to metformin. Severe renal impairment (eGFR below 30 mL/min/1.73 m(2)). |
| Adverse Effects | Common Endocrine metabolic: Cobalamin deficiency (7% to 17.4% ) Gastrointestinal: Diarrhea (53% (immediate-release) ; 10% to 13% (extended-release) ), Flatulence (12% ), Indigestion (7% ), Malabsorption syndrome (Up to 9.9% ), Nausea (7% (extended-release) ), Vomiting (Up to 25.5% ) Neurologic: Asthenia (9% ), Headache (6% ) Serious Endocrine metabolic: Lactic acidosis Hepatic: Hepatitis |
| Pregnancy | Human Data Suggest Low Risk |
| Lactation | Compatible |
| More Info | UpToDate |