| TAH Drug Code | OOFE |
|---|---|
| Indications | Idiopathic pulmonary fibrosis (IPF), progressive pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease. |
| Dosing | 150 mg orally every 12 hours (maximum: 300 mg/day)Administer with food. Swallow capsules whole with liquid; do not chew or crush. |
| Hepatic Impairment | Dose adjustment required |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Hypersensitivity to nintedanib, peanut or soya. Pregnancy & lactation. |
| Adverse Effects | Diarrhoea, nausea, abdominal pain; increased hepatic enzyme. Decreased wt & appetite; epistaxis; vomiting; increased alanine aminotransferase (ALT), aspartate aminotransferase (AST) & γ-glutamyl transferase (GGT). |
| Pregnancy | No (Limited) Human Data – Animal Data Suggest Risk |
| Lactation | No (Limited) Human Data - Potential Toxicity |
| More Info | UpToDate |