| TAH Drug Code | EAZA |
|---|---|
| Indications | Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma |
| Dosing | Instill 1 drop BID into the conjunctival sac. Age <18 years: Not recommend use. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Hypersensitivity to brinzolamide, timolol, other beta-blockers, sulfonamides, or any component of the formulation; current or history of bronchial asthma; severe chronic obstructive pulmonary disease (COPD); severe allergic rhinitis and bronchial hyper-reactivity; sinus bradycardia, second-/third degree atrioventricular (AV) block, overt cardiac failure, cardiogenic shock; hyperchloremic acidosis; severe renal impairment |
| Adverse Effects | Taste perversion (2%), Blurred vision (6%), eye irritation (4%), eye pain (3%), foreign body sensation in eyes (1%) |
| Pregnancy | Human Data Suggest Risk in 2nd and 3rd Trimesters |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |