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Budesonide

Duasma HFA Inhaler 200mcg/puff, 200 puffs

TAH Drug Code EDUAH
Indications Bronchial asthma
Dosing For adults and children aged 12 and above: Initial dose: 400-1600 mcg/day, divided into 2-4 doses. Maintenance dose: 200-400 mcg/day, divided into 2 doses. For children aged 6-12: Initial dose: 200-400 mcg/day, divided into 2 doses. Maintenance dose: Individualized-the minimum dose needed-keep patients symptom-free. For stable asthma, twice daily usage is usually sufficient. Patients using inhaled bronchodilators should use the bronchodilator a few minutes before using Budesonide to enhance drug penetration into the bronchial branches and reduce local side effects, such as cough. When the dose exceeds 800mcg, the use of a spacer is recommended, as it can reduce systemic absorption and improve drug deposition in the lungs.
Hepatic Impairment Dose adjustment not necessary
Renal Impairment Dose adjustment not necessary
Contraindications Hypersensitivity to budesonide or any component of the formulation. Moderate to severe bronchial dilation.
Adverse Effects Common: Hypertension (Oral, 12%), Peripheral edema (Oral, 17%), Acne (Oral, 2.4-11%), Dermatitis (Oral, 6%), Hirsutism (Oral, 5%), Weight gain (Inhalation, 1-3% ; oral, 7%), Diarrhea (Inhalation, 2-4% ; oral, 10%), Indigestion (Oral, 6-7%), Nausea (Inhalation, 1.8% ; oral, 5.1-11%; rectal, 2%), Leukocytosis (Oral, up to 6%), Arthralgia (Oral, 2-6%), Spasm (Oral, 12%), Headache (Inhalation, >3% ; oral, 10-21%), Bleeding from nose (Inhalation, 2-4% ; intranasal, 8%), Dyspnea (Oral, 6%), Nasal stinging/burning (Intranasal, up to 1%), Respiratory tract infection (Inhalation, 3-38% ; oral, 8-11%), Sinusitis (Inhalation, 3% or greater ; oral, 8%), Edema of face (Oral, 8%), Fatigue (Inhalation, 1-<3% ; oral, 3.1-5%) Serious: Syncope (Inhalation, 1-3%), Cushing's syndrome (Oral, 5-15% ; inhalation, rare), Hyperglycemia, Hypocortisolism secondary to another disorder (Inhalation, rare ; oral, 4.3% ; rectal, 4%), Type 2 diabetes mellitus, Anaphylaxis, Hypersensitivity reaction, Fracture of bone (Inhalation, 1-3%), Osteoporosis, Cataract, Glaucoma, Pneumonia, Angioedema
Pregnancy Compatible
Lactation No (Limited) Human Data - Probably Compatible
More Info UpToDate

Pulmicort respules 1mg/2mL

TAH Drug Code EPULR
Indications Patients with bronchial asthma not well controlled by bronchodilators &/or antiallergic agents.
Dosing The required dose can be administered at one time under 1mg, otherwise, divided in 2 times daily when the required dose above 1mg. Adult: Initial dose: 1-2 mg daily. Maintenance dose: 0.5-4mg daily. May increase the dosage with the very severe patient. Child > 6 months: Loading dose: 0.25-0.5mg daily. May up to 1mg daily if required. Maintenance dose: 0.25-2mg daily.
Hepatic Impairment Dose adjustment not necessary
Renal Impairment Dose adjustment not necessary
Contraindications Hypersensitivity to budesonide or any other ingredients.
Adverse Effects Common: Hypertension (Oral, 12%), Peripheral edema (Oral, 17%), Acne (Oral, 2.4-11%), Dermatitis (Oral, 6%), Hirsutism (Oral, 5%), Weight gain (Inhalation, 1-3% ; oral, 7%), Diarrhea (Inhalation, 2-4% ; oral, 10%), Indigestion (Oral, 6-7%), Nausea (Inhalation, 1.8% ; oral, 5.1-11%; rectal, 2%), Leukocytosis (Oral, up to 6%), Arthralgia (Oral, 2-6%), Spasm (Oral, 12%), Headache (Inhalation, >3% ; oral, 10-21%), Bleeding from nose (Inhalation, 2-4% ; intranasal, 8%), Dyspnea (Oral, 6%), Nasal stinging/burning (Intranasal, up to 1%), Respiratory tract infection (Inhalation, 3-38% ; oral, 8-11%), Sinusitis (Inhalation, 3% or greater ; oral, 8%), Edema of face (Oral, 8%), Fatigue (Inhalation, 1-<3% ; oral, 3.1-5%) Serious: Syncope (Inhalation, 1-3%), Cushing's syndrome (Oral, 5-15% ; inhalation, rare), Hyperglycemia, Hypocortisolism secondary to another disorder (Inhalation, rare ; oral, 4.3% ; rectal, 4%), Type 2 diabetes mellitus, Anaphylaxis, Hypersensitivity reaction, Fracture of bone (Inhalation, 1-3%), Osteoporosis, Cataract, Glaucoma, Pneumonia, Angioedema
Pregnancy Compatible
Lactation No (Limited) Human Data - Probably Compatible
More Info UpToDate