| TAH Drug Code | OUROS |
|---|---|
| Indications | Relieve bladder pain or discomfort caused by interstitial cystitis. |
| Dosing | Usual dosage (16 years or older): 300 mg, administered as 100 mg orally three times a day taken either 1 hour before or 2 hours after meals. At least 3 months of therapy should be given before patient reassessment; if no benefit is noted at 3 months, an additional 3 months of therapy is warranted, provided the patient has exhibited no limiting adverse reactions. The efficacy and safety of continued treatment beyond 6 months in patients with lack of improvement in pain is not known. |
| Hepatic Impairment | Dose adjustment not necessary |
| Renal Impairment | Dose adjustment not necessary |
| Contraindications | Hypersensitivity to pentosan polysulfate sodium, any structurally related compound, or excipients. |
| Adverse Effects | Common: Alopecia (4%), Rash (3%), Abdominal pain (2%), Diarrhea (4%), Indigestion (Up to 2%), Nausea (4%), Liver enzymes level above reference range (Up to 1.2%), Dizziness (1%), Headache (3%) Serious: Proctitis, Rectal hemorrhage (6.3%), Hemorrhage, Thrombocytopenia (Up to 1%), Retinal disorder, Pigmentary changes |
| Pregnancy | No (Limited) Human Data – Animal Data Suggest Low Risk |
| Lactation | No (Limited) Human Data - Probably Compatible |
| More Info | UpToDate |