From a6b16392ff5536b6588dc0b14228a790b0d33866 Mon Sep 17 00:00:00 2001 From: MICHAEL SHORTREED Date: Thu, 18 Nov 2021 12:30:51 -0600 Subject: [PATCH 01/11] correct Within calculation --- MassSpectrometry/MzSpectra/SpectralSimilarity.cs | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/MassSpectrometry/MzSpectra/SpectralSimilarity.cs b/MassSpectrometry/MzSpectra/SpectralSimilarity.cs index e9600bfdd..4fcc00e77 100644 --- a/MassSpectrometry/MzSpectra/SpectralSimilarity.cs +++ b/MassSpectrometry/MzSpectra/SpectralSimilarity.cs @@ -14,7 +14,7 @@ public SpectralSimilarity(MzSpectrum primary, MzSpectrum secondary, SpectrumNorm primaryXArray = primary.XArray; secondaryYarray = Normalize(secondary.YArray, scheme); secondaryXArray = secondary.XArray; - localTolerance = toleranceInPpm / 1000000.0; + ppmTolerance = toleranceInPpm; _intensityPairs = IntensityPairs(allPeaks); } @@ -24,7 +24,7 @@ public SpectralSimilarity(MzSpectrum primary, double[] secondaryX, double[] seco primaryXArray = primary.XArray; secondaryYarray = Normalize(secondaryY, scheme); secondaryXArray = secondaryX; - localTolerance = toleranceInPpm / 1000000.0; + ppmTolerance = toleranceInPpm; _intensityPairs = IntensityPairs(allPeaks); } @@ -32,7 +32,7 @@ public SpectralSimilarity(MzSpectrum primary, double[] secondaryX, double[] seco public double[] primaryXArray { get; private set; } public double[] secondaryYarray { get; private set; } public double[] secondaryXArray { get; private set; } - private double localTolerance; + private double ppmTolerance; private List<(double, double)> _intensityPairs = new List<(double, double)>(); public List<(double, double)> intensityPairs @@ -236,7 +236,7 @@ public double DotProduct() private bool Within(double mz1, double mz2) { - return (Math.Abs(mz1 - mz2) < localTolerance); + return (Math.Abs(mz1 - mz2)/mz1*1000000.0 < ppmTolerance); } public enum SpectrumNormalizationScheme From fa4da8bb9e174a4343c6b530b47172f1449c730e Mon Sep 17 00:00:00 2001 From: MICHAEL SHORTREED Date: Thu, 18 Nov 2021 12:42:10 -0600 Subject: [PATCH 02/11] update unit tests --- Test/TestSpectralSimilarity.cs | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/Test/TestSpectralSimilarity.cs b/Test/TestSpectralSimilarity.cs index 356158e04..ebc19e9af 100644 --- a/Test/TestSpectralSimilarity.cs +++ b/Test/TestSpectralSimilarity.cs @@ -117,10 +117,10 @@ public void TestAllSpectrumSimilarities() //explore bounds of binary search primary = new MzSpectrum(new double[] { 1, 2, 3, 4 }, new double[] { 1, 2, 3, 4 }, false); - secondary = new MzSpectrum(new double[] { 1.000009, 1.99999, 3.00004, 3.99995 }, new double[] { 1, 2, 3, 4 }, false); + secondary = new MzSpectrum(new double[] { 1.000011, 1.99997, 3.000031, 3.99995 }, new double[] { 1, 2, 3, 4 }, false); s = new SpectralSimilarity(primary, secondary, SpectralSimilarity.SpectrumNormalizationScheme.spectrumSum, ppmTolerance, true); - Assert.AreEqual(7, s.intensityPairs.Count); + Assert.AreEqual(8, s.intensityPairs.Count); //Test alternate constructor primary = new MzSpectrum(new double[] { 1, 2, 3 }, new double[] { 2, 4, 6 }, false); From 892fa451204f0b54f3e54301a0bc5b250410f48a Mon Sep 17 00:00:00 2001 From: MICHAEL SHORTREED Date: Fri, 18 Feb 2022 09:57:06 -0600 Subject: [PATCH 03/11] this is the spot --- FlashLFQ/FlashLfqEngine.cs | 2 ++ 1 file changed, 2 insertions(+) diff --git a/FlashLFQ/FlashLfqEngine.cs b/FlashLFQ/FlashLfqEngine.cs index 0bc9d5818..6037e2098 100644 --- a/FlashLFQ/FlashLfqEngine.cs +++ b/FlashLFQ/FlashLfqEngine.cs @@ -914,6 +914,8 @@ private void QuantifyMatchBetweenRunsPeaks(SpectraFileInfo idAcceptorFile) } } + //here is where we get the cosine similarity. + _results.Peaks[idAcceptorFile].Add(best); } From b4ad2317ed6e7df53d0d1956faa79692a669c95b Mon Sep 17 00:00:00 2001 From: Michael Shortreed Date: Thu, 29 Jun 2023 11:09:39 -0500 Subject: [PATCH 04/11] add space --- mzLib/Test/TestBayesianEstimation.cs | 1 + 1 file changed, 1 insertion(+) diff --git a/mzLib/Test/TestBayesianEstimation.cs b/mzLib/Test/TestBayesianEstimation.cs index e7045e5a6..05c83a0e9 100644 --- a/mzLib/Test/TestBayesianEstimation.cs +++ b/mzLib/Test/TestBayesianEstimation.cs @@ -95,6 +95,7 @@ public static void TestOneSampleBayesianEstimation() Assert.That(Math.Round(highestDensityInterval.hdi_end, 3) == 1.062); } + [Test] /// /// Bayesian estimation of the difference in means between two samples. From ad4070553355b18962801111e826a50081622d3f Mon Sep 17 00:00:00 2001 From: Michael Shortreed Date: Mon, 14 Aug 2023 13:56:24 -0500 Subject: [PATCH 05/11] New peptideWithSetMods output with mass shift in brackets --- .../PeptideWithSetModifications.cs | 50 + mzLib/Test/DatabaseTests/fullSequences.txt | 134 + .../fullSequencesWithMassShift.txt | 134 + mzLib/Test/DatabaseTests/humanGAPDH.xml | 3574 +++++++++++++++++ mzLib/Test/Test.csproj | 9 + mzLib/Test/TestPeptideWithSetMods.cs | 32 + 6 files changed, 3933 insertions(+) create mode 100644 mzLib/Test/DatabaseTests/fullSequences.txt create mode 100644 mzLib/Test/DatabaseTests/fullSequencesWithMassShift.txt create mode 100644 mzLib/Test/DatabaseTests/humanGAPDH.xml diff --git a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs index 4f391729d..fc10f13d2 100644 --- a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs +++ b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs @@ -929,6 +929,11 @@ public override string ToString() return FullSequence + string.Join("\t", AllModsOneIsNterminus.Select(m => m.ToString())); } + public string FullSequenceWithMassShift() + { + return DetermineFullSequenceWithMassShifts(); + } + public override bool Equals(object obj) { var q = obj as PeptideWithSetModifications; @@ -1091,6 +1096,51 @@ private void DetermineFullSequence() FullSequence = subsequence.ToString(); } + private string DetermineFullSequenceWithMassShifts() + { + var subsequence = new StringBuilder(); + + // modification on peptide N-terminus + if (AllModsOneIsNterminus.TryGetValue(1, out Modification mod)) + { + subsequence.Append('[' + mod.MonoisotopicMass.ToString() + ']'); + } + + for (int r = 0; r < Length; r++) + { + subsequence.Append(this[r]); + + // modification on this residue + if (AllModsOneIsNterminus.TryGetValue(r + 2, out mod)) + { + if (mod.MonoisotopicMass > 0) + { + subsequence.Append("[+" + mod.MonoisotopicMass.ToString() + ']'); + } + else + { + subsequence.Append("[" + mod.MonoisotopicMass.ToString() + ']'); + } + + } + } + + // modification on peptide C-terminus + if (AllModsOneIsNterminus.TryGetValue(Length + 2, out mod)) + { + if (mod.MonoisotopicMass > 0) + { + subsequence.Append("[+" + mod.MonoisotopicMass.ToString() + ']'); + } + else + { + subsequence.Append("[" + mod.MonoisotopicMass.ToString() + ']'); + } + } + + return subsequence.ToString(); + } + private void UpdateCleavageSpecificity() { if (CleavageSpecificityForFdrCategory == CleavageSpecificity.Unknown) diff --git a/mzLib/Test/DatabaseTests/fullSequences.txt b/mzLib/Test/DatabaseTests/fullSequences.txt new file mode 100644 index 000000000..a7061f007 --- /dev/null +++ b/mzLib/Test/DatabaseTests/fullSequences.txt @@ -0,0 +1,134 @@ +[UniProt:N-methylmethionine on M]M[UniProt:S-methylmethionine on M]GK[UniProt:O-linked (Hex) hydroxylysine on K] +[UniProt:N-palmitoyl glycine on G]GK[UniProt:O-linked (Hex) hydroxylysine on K] +[UniProt:N-acetylglycine on G]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]K[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]GV[UniProt:N-methylvaline on V]N[UniProt:N-linked (HexNAc) asparagine on N]GF[UniProt:3-hydroxyphenylalanine on F]GR[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]GV[UniProt:N-methylvaline on V]N[UniProt:Deamidated asparagine on N]GF[UniProt:3-hydroxyphenylalanine on F]GR[UniProt:N-linked (HexNAc) arginine on R] +I[UniProt:N-methylisoleucine on I]GR[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]T[UniProt:O-linked (HexNAc) threonine on T]R[UniProt:N-linked (HexNAc) arginine on R] +AAF[UniProt:3-hydroxyphenylalanine on F]N[UniProt:N-linked (HexNAc) asparagine on N]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]AI[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]F[UniProt:3-hydroxyphenylalanine on F]I[UniProt:N-methylisoleucine on I]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:S-methylmethionine on M]V[UniProt:N-methylvaline on V]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:S-methylmethionine on M]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]AI[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]F[UniProt:3-hydroxyphenylalanine on F]I[UniProt:N-methylisoleucine on I]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:S-methylmethionine on M]V[UniProt:N-methylvaline on V]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:Methionine sulfoxide on M]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]AI[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]F[UniProt:3-hydroxyphenylalanine on F]I[UniProt:N-methylisoleucine on I]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]Y[UniProt:Phosphotyrosine on Y]M[UniProt:S-methylmethionine on M]V[UniProt:N-methylvaline on V]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:S-methylmethionine on M]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]AI[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]F[UniProt:3-hydroxyphenylalanine on F]I[UniProt:N-methylisoleucine on I]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]Y[UniProt:Phosphotyrosine on Y]M[UniProt:S-methylmethionine on M]V[UniProt:N-methylvaline on V]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:Methionine sulfoxide on M]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]GK[UniProt:O-linked (Hex) hydroxylysine on K] +F[UniProt:3-hydroxyphenylalanine on F]H[UniProt:N-linked (Glc) (glycation) histidine on H]GT[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]K[UniProt:O-linked (Hex) hydroxylysine on K] +F[UniProt:3-hydroxyphenylalanine on F]H[UniProt:N-linked (Glc) (glycation) histidine on H]GT[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]K[UniProt:N6-acetyllysine on K] +AE[UniProt:Glutamate methyl ester (Glu) on E]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:O-linked (Hex) hydroxylysine on K] +AE[UniProt:Glutamate methyl ester (Glu) on E]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:N6,N6-dimethyllysine on K] +AE[UniProt:Glutamate methyl ester (Glu) on E]N[UniProt:Deamidated asparagine on N]GK[UniProt:O-linked (Hex) hydroxylysine on K] +AE[UniProt:Glutamate methyl ester (Glu) on E]N[UniProt:Deamidated asparagine on N]GK[UniProt:N6,N6-dimethyllysine on K] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]GN[UniProt:N-linked (HexNAc) asparagine on N]P[UniProt:O-linked (HexNAc) hydroxyproline on P]I[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]I[UniProt:N-methylisoleucine on I]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]E[UniProt:Glutamate methyl ester (Glu) on E]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]GN[UniProt:N-linked (HexNAc) asparagine on N]P[UniProt:O-linked (HexNAc) hydroxyproline on P]I[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]I[UniProt:N-methylisoleucine on I]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]E[UniProt:Glutamate methyl ester (Glu) on E]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]N[UniProt:Deamidated asparagine on N]GN[UniProt:N-linked (HexNAc) asparagine on N]P[UniProt:O-linked (HexNAc) hydroxyproline on P]I[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]I[UniProt:N-methylisoleucine on I]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]E[UniProt:Glutamate methyl ester (Glu) on E]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]N[UniProt:Deamidated asparagine on N]GN[UniProt:N-linked (HexNAc) asparagine on N]P[UniProt:O-linked (HexNAc) hydroxyproline on P]I[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]I[UniProt:N-methylisoleucine on I]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]E[UniProt:Glutamate methyl ester (Glu) on E]R[UniProt:N-linked (HexNAc) arginine on R] +D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]K[UniProt:O-linked (Hex) hydroxylysine on K] +D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:Phosphoserine on S]K[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]K[UniProt:O-linked (Hex) hydroxylysine on K] +W[UniProt:N-linked (Hex) tryptophan on W]GD[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]AGAE[UniProt:Glutamate methyl ester (Glu) on E]Y[UniProt:O-linked (HexNAc) tyrosine on Y]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]GV[UniProt:N-methylvaline on V]F[UniProt:3-hydroxyphenylalanine on F]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]M[UniProt:S-methylmethionine on M]E[UniProt:Glutamate methyl ester (Glu) on E]K[UniProt:O-linked (Hex) hydroxylysine on K] +AGAH[UniProt:N-linked (Glc) (glycation) histidine on H]L[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]GGAK[UniProt:O-linked (Hex) hydroxylysine on K] +R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]AD[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]M[UniProt:S-methylmethionine on M]F[UniProt:3-hydroxyphenylalanine on F]V[UniProt:N-methylvaline on V]M[UniProt:S-methylmethionine on M]GV[UniProt:N-methylvaline on V]N[UniProt:N-linked (HexNAc) asparagine on N]H[UniProt:N-linked (Glc) (glycation) histidine on H]E[UniProt:Glutamate methyl ester (Glu) on E]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]AD[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]M[UniProt:S-methylmethionine on M]F[UniProt:3-hydroxyphenylalanine on F]V[UniProt:N-methylvaline on V]M[UniProt:S-methylmethionine on M]GV[UniProt:N-methylvaline on V]N[UniProt:N-linked (HexNAc) asparagine on N]H[UniProt:N-linked (Glc) (glycation) histidine on H]E[UniProt:Glutamate methyl ester (Glu) on E]K[UniProt:O-linked (Hex) hydroxylysine on K] +Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]S[UniProt:O-linked (HexNAc) serine on S]L[UniProt:(4R)-5-oxoleucine on L]K[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]AT[UniProt:O-linked (HexNAc) threonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]AT[UniProt:Phosphothreonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]AT[UniProt:O-linked (HexNAc) threonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:Phosphothreonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]AT[UniProt:O-linked (HexNAc) threonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]AT[UniProt:Phosphothreonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:Phosphothreonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]AT[UniProt:Phosphothreonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:Phosphothreonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]AT[UniProt:O-linked (HexNAc) threonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:O-linked (Hex) hydroxylysine on K] +T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:N6,N6-dimethyllysine on K] +T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:N6-acetyllysine on K] +T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:N6-malonyllysine on K] +L[UniProt:(4R)-5-oxoleucine on L]W[UniProt:N-linked (Hex) tryptophan on W]R[UniProt:N-linked (HexNAc) arginine on R] +D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GR[UniProt:N-linked (HexNAc) arginine on R] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]GAAK[UniProt:O-linked (Hex) hydroxylysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]GAAK[UniProt:N6,N6-dimethyllysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]GAAK[UniProt:N6-malonyllysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:Phosphothreonine on T]GAAK[UniProt:O-linked (Hex) hydroxylysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:Phosphothreonine on T]GAAK[UniProt:N6,N6-dimethyllysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:Phosphothreonine on T]GAAK[UniProt:N6-malonyllysine on K] +AV[UniProt:N-methylvaline on V]GK[UniProt:O-linked (Hex) hydroxylysine on K] +AV[UniProt:N-methylvaline on V]GK[UniProt:N6-acetyllysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:N6-acetyllysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:Deamidated asparagine on N]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:Deamidated asparagine on N]GK[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:Deamidated asparagine on N]GK[UniProt:N6-acetyllysine on K] +L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]GM[UniProt:S-methylmethionine on M]AF[UniProt:3-hydroxyphenylalanine on F]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:Phosphothreonine on T]GM[UniProt:S-methylmethionine on M]AF[UniProt:3-hydroxyphenylalanine on F]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-linked (HexNAc) cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-(2-succinyl)cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-nitrosocysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:Phosphoserine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-linked (HexNAc) cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:Phosphothreonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-linked (HexNAc) cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:Phosphoserine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-(2-succinyl)cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:Phosphoserine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-nitrosocysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:Phosphothreonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-(2-succinyl)cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:Phosphothreonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-nitrosocysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:Phosphothreonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:Phosphoserine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-linked (HexNAc) cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]E[UniProt:Glutamate methyl ester (Glu) on E]K[UniProt:O-linked (Hex) hydroxylysine on K] +P[UniProt:O-linked (HexNAc) hydroxyproline on P]AK[UniProt:O-linked (Hex) hydroxylysine on K] +P[UniProt:O-linked (HexNAc) hydroxyproline on P]AK[UniProt:N6-acetyllysine on K] +Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]K[UniProt:O-linked (Hex) hydroxylysine on K] +K[UniProt:O-linked (Hex) hydroxylysine on K] +K[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]K[UniProt:N6,N6-dimethyllysine on K] +Q[UniProt:5-glutamyl serotonin on Q]AS[UniProt:O-linked (HexNAc) serine on S]E[UniProt:Glutamate methyl ester (Glu) on E]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]K[UniProt:O-linked (Hex) hydroxylysine on K] +GI[UniProt:N-methylisoleucine on I]L[UniProt:(4R)-5-oxoleucine on L]GY[UniProt:O-linked (HexNAc) tyrosine on Y]T[UniProt:O-linked (HexNAc) threonine on T]E[UniProt:Glutamate methyl ester (Glu) on E]H[UniProt:N-linked (Glc) (glycation) histidine on H]Q[UniProt:5-glutamyl serotonin on Q]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]S[UniProt:O-linked (HexNAc) serine on S]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]F[UniProt:3-hydroxyphenylalanine on F]N[UniProt:N-linked (HexNAc) asparagine on N]S[UniProt:O-linked (HexNAc) serine on S]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]S[UniProt:O-linked (HexNAc) serine on S]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]F[UniProt:3-hydroxyphenylalanine on F]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]AGAGI[UniProt:N-methylisoleucine on I]AL[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]H[UniProt:N-linked (Glc) (glycation) histidine on H]F[UniProt:3-hydroxyphenylalanine on F]V[UniProt:N-methylvaline on V]K[UniProt:O-linked (Hex) hydroxylysine on K] +L[UniProt:(4R)-5-oxoleucine on L]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]W[UniProt:N-linked (Hex) tryptophan on W]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]E[UniProt:Glutamate methyl ester (Glu) on E]F[UniProt:3-hydroxyphenylalanine on F]GY[UniProt:O-linked (HexNAc) tyrosine on Y]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]W[UniProt:N-linked (Hex) tryptophan on W]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:Deamidated asparagine on N]E[UniProt:Glutamate methyl ester (Glu) on E]F[UniProt:3-hydroxyphenylalanine on F]GY[UniProt:O-linked (HexNAc) tyrosine on Y]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]W[UniProt:N-linked (Hex) tryptophan on W]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]E[UniProt:Glutamate methyl ester (Glu) on E]F[UniProt:3-hydroxyphenylalanine on F]GY[UniProt:O-linked (HexNAc) tyrosine on Y]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]W[UniProt:N-linked (Hex) tryptophan on W]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:Deamidated asparagine on N]E[UniProt:Glutamate methyl ester (Glu) on E]F[UniProt:3-hydroxyphenylalanine on F]GY[UniProt:O-linked (HexNAc) tyrosine on Y]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]AH[UniProt:N-linked (Glc) (glycation) histidine on H]M[UniProt:S-methylmethionine on M]AS[UniProt:O-linked (HexNAc) serine on S]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]AH[UniProt:N-linked (Glc) (glycation) histidine on H]M[UniProt:S-methylmethionine on M]AS[UniProt:O-linked (HexNAc) serine on S]K[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]AH[UniProt:N-linked (Glc) (glycation) histidine on H]M[UniProt:S-methylmethionine on M]AS[UniProt:Phosphoserine on S]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]AH[UniProt:N-linked (Glc) (glycation) histidine on H]M[UniProt:S-methylmethionine on M]AS[UniProt:Phosphoserine on S]K[UniProt:N6,N6-dimethyllysine on K] +E[UniProt:Glutamate methyl ester (Glu) on E][UniProt:Glutamic acid 1-amide on E] +E[UniProt:Glutamate methyl ester (Glu) on E][UniProt:5-glutamyl 2-aminoadipic acid on E] +[UniProt:N-palmitoyl glycine on G]GK[UniProt:O-linked (Hex) hydroxylysine on K] +[UniProt:N-acetylglycine on G]GK[UniProt:O-linked (Hex) hydroxylysine on K] diff --git a/mzLib/Test/DatabaseTests/fullSequencesWithMassShift.txt b/mzLib/Test/DatabaseTests/fullSequencesWithMassShift.txt new file mode 100644 index 000000000..43ff1ca79 --- /dev/null +++ b/mzLib/Test/DatabaseTests/fullSequencesWithMassShift.txt @@ -0,0 +1,134 @@ +[14.01565]M[+14.015650533]GK[+178.047738] +[238.229666]GK[+178.047738] +[42.010565]GK[+178.047738] +V[+14.01565]K[+178.047738] +V[+14.01565]K[+28.0313] 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+L[+13.979265]I[+14.01565]S[+79.966331]W[+162.052823]Y[+203.079373]D[+294.183109]N[+0.984016]E[+14.01565]F[+15.994915]GY[+203.079373]S[+203.079373]N[+203.079373]R[+203.079373] +V[+14.01565]V[+14.01565]D[+294.183109]L[+13.979265]M[+14.015650533]AH[+162.052823]M[+14.015650533]AS[+203.079373]K[+178.047738] +V[+14.01565]V[+14.01565]D[+294.183109]L[+13.979265]M[+14.015650533]AH[+162.052823]M[+14.015650533]AS[+203.079373]K[+28.0313] +V[+14.01565]V[+14.01565]D[+294.183109]L[+13.979265]M[+14.015650533]AH[+162.052823]M[+14.015650533]AS[+79.966331]K[+178.047738] +V[+14.01565]V[+14.01565]D[+294.183109]L[+13.979265]M[+14.015650533]AH[+162.052823]M[+14.015650533]AS[+79.966331]K[+28.0313] +E[+14.01565][-0.984016] +E[+14.01565][+143.058243] +[238.229666]GK[+178.047738] +[42.010565]GK[+178.047738] diff --git a/mzLib/Test/DatabaseTests/humanGAPDH.xml b/mzLib/Test/DatabaseTests/humanGAPDH.xml new file mode 100644 index 000000000..16cf2fa5d --- /dev/null +++ b/mzLib/Test/DatabaseTests/humanGAPDH.xml @@ -0,0 +1,3574 @@ + + + +P04406 +E7EUT4 +P00354 +Q53X65 +G3P_HUMAN + + +Glyceraldehyde-3-phosphate dehydrogenase +GAPDH +1.2.1.12 + + +Peptidyl-cysteine S-nitrosylase GAPDH +2.6.99.- + + + +GAPDH +GAPD +CDABP0047 +OK/SW-cl.12 + + +Homo sapiens +Human + + +Eukaryota +Metazoa +Chordata +Craniata +Vertebrata +Euteleostomi +Mammalia +Eutheria +Euarchontoglires +Primates +Haplorrhini +Catarrhini +Hominidae +Homo + + + + + +The glyceraldehyde 3 phosphate dehydrogenase gene family: structure of a human cDNA and of an X chromosome linked pseudogene; amazing complexity of the gene family in mouse. + + + + + + + + +NUCLEOTIDE SEQUENCE [MRNA] + + + + +The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species. + + + + + + + + + +NUCLEOTIDE SEQUENCE [MRNA] + + + + +Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. + + + + + + + + + + + +NUCLEOTIDE SEQUENCE [MRNA] + +Liver + + + + + +Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. + + + + + + + + + + + + +NUCLEOTIDE SEQUENCE [MRNA] + +Lung + + + + + +Identification of the 37-kDa protein displaying a variable interaction with the erythroid cell membrane as glyceraldehyde-3-phosphate dehydrogenase. + + + + + + + + + +NUCLEOTIDE SEQUENCE [MRNA] + + + + +Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene. + + + + + + + + + + +NUCLEOTIDE SEQUENCE [GENOMIC DNA] +FUNCTION +CATALYTIC ACTIVITY + + + + +A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase. + + + + + + + + + + + + +NUCLEOTIDE SEQUENCE [MRNA] + +Placenta + + + + + +cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. + + + + + + + + +NUCLEOTIDE SEQUENCE [MRNA] + +Astrocytoma + + + + +Pediatric leukemia cDNA sequencing project. + + + + + + + + + + + +NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] + +Leukemia + + + + + +Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients. + + + + + + +NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] + +Colon adenocarcinoma + + + + + +Cloning of human full-length CDSs in BD Creator(TM) system donor vector. + + + + + + + + + + + + + + + + + + +NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] + + + + + + + +NUCLEOTIDE SEQUENCE [GENOMIC DNA] +VARIANT GLY-22 + + + + +Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). + + + + + + + + + + +NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] + + + +The finished DNA sequence of human chromosome 12. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] + + + + +The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). + + + + + + + +NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] + +Eye +Kidney +Lung +Lymph +Placenta + + + + + +The complete amino acid sequence of human muscle glyceraldehyde 3-phosphate dehydrogenase. + + + + + + + + + +PRELIMINARY PROTEIN SEQUENCE OF 2-335 + +Muscle + + + + + +Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. + + + + + + + + + + + + + +PROTEIN SEQUENCE OF 2-13 + +Platelet + + + + + + + + + + + +PROTEIN SEQUENCE OF 2-13; 62-84; 118-139; 198-215; 220-227; 235-248 AND 310-335 + +CLEAVAGE OF INITIATOR METHIONINE +IDENTIFICATION BY MASS SPECTROMETRY + +Prostatic carcinoma + + + + + + + + + + + + +PROTEIN SEQUENCE OF 67-80; 87-107; 119-139; 146-186; 201-215; 235-248 AND 310-334 + +IDENTIFICATION BY MASS SPECTROMETRY + +Brain +Cajal-Retzius cell +Fetal brain cortex + + + + + +The major protein expression profile and two-dimensional protein database of human heart. + + + + + + + + + + + + + +PROTEIN SEQUENCE OF 220-226 AND 242-246 + +Heart + + + + + +The covalent structure of glyceraldehyde-phosphate dehydrogenase from human muscles. Isolation and amino acid sequences of peptides from tryptic digest. + + + + + + + + + + + +PARTIAL PROTEIN SEQUENCE + +Muscle + + + + + +Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway. + + + + + + + +FUNCTION +INTERACTION WITH PRKCI + + + + +Subcellular localization of human glyceraldehyde-3-phosphate dehydrogenase is independent of its glycolytic function. + + + + + + + + +SUBCELLULAR LOCATION + + + + +Proteomic characterization of the human centrosome by protein correlation profiling. + + + + + + + + + + + + +IDENTIFICATION BY MASS SPECTROMETRY + +Lymphoblast + + + + + +Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. + + + + + + + + + + + + + + + + + +IDENTIFICATION IN THE GAIT COMPLEX + + + + +Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase. + + + + + + + + + +INTERACTION WITH WARS1 + + + + +Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. + + + + + + + + + + + + + + + + +PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-42 + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + + + + +Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. + + + + + + + + + + + + + +PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + +Cervix carcinoma + + + + + +The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. + + + + + + + + + + + +INTERACTION WITH USP25 + + + + +HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. + + + + + + + + + + +ISGYLATION + + + + +Strategy for comprehensive identification of post-translational modifications in cellular proteins, including low abundant modifications: application to glyceraldehyde-3-phosphate dehydrogenase. + + + + + + + + + + + + + +PHOSPHORYLATION AT THR-75; SER-122; SER-148; THR-229; THR-237 AND SER-312 + + +DEAMIDATION AT ASN-9; ASN-64; ASN-70; ASN-149; ASN-155; ASN-225 AND ASN-316 + + +METHYLATION AT LYS-5; LYS-66; LYS-194; LYS-215; LYS-227; LYS-260; LYS-263 AND LYS-334 + + + + +A quantitative atlas of mitotic phosphorylation. + + + + + + + + + + + + + +PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-151 AND THR-184 + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + +Cervix carcinoma + + + + + +Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. + + + + + + + + + + + + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + + + + +FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor. + + + + + + + + + + + + +INTERACTION WITH FKBP6 + + + + +Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. + + + + + + + + + + + + + + + +PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-184; THR-211 AND SER-312 + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + +Leukemic T-cell + + + + + +Lysine acetylation targets protein complexes and co-regulates major cellular functions. + + + + + + + + + + + + + + + +ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-61; LYS-194; LYS-219; LYS-227 AND LYS-254 + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + + + + +Haponin (eIF1AD) interacts with glyceraldehyde 3-phosphate dehydrogenase in the CHO-K1 cell line. + + + + + + + + + + + + +INTERACTION WITH EIF1AD + + + + +Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. + + + + + + + + + + + + + + + + + + + +PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-75; SER-83 AND THR-184 + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + +Cervix carcinoma + + + + + +Initial characterization of the human central proteome. + + + + + + + + + + + + + + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + + + + +The first identification of lysine malonylation substrates and its regulatory enzyme. + + + + + + + + + + + + + + + + + + + + + + + + + +MALONYLATION AT LYS-194 AND LYS-215 + + + + +System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. + + + + + + + + + + + + + + + + +PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + + + + +Resveratrol-induced changes of the human adipocyte secretion profile. + + + + + + + + + + + + + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + + + + +Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation. + + + + + + + + + + + + + +INTERACTION WITH RPL13A +S-NITROSYLATION AT CYS-247 + + + + +Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. + + + + + + + + + + +FUNCTION +RECONSTITUTION OF THE GAIT COMPLEX + + + + +N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. + + + + + + + + + + + + + + + + + + + + + + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + + + + +NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-kappaB activation. + + + + + + + + + + + + + + + + +FUNCTION +GLYCOSYLATION (MICROBIAL INFECTION) +INTERACTION WITH TRAF2 + +MUTAGENESIS OF CYS-152; THR-211; THR-229; SER-241; THR-246 AND THR-277 + + + + + +Toward a comprehensive characterization of a human cancer cell phosphoproteome. + + + + + + + + + + + + + + +PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-151; THR-153; THR-229 AND SER-333 + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + +Cervix carcinoma +Erythroleukemia + + + + + +Target-selective protein S-nitrosylation by sequence motif recognition. + + + + + + + + + + + + + +S-NITROSYLATION AT CYS-247 +MUTAGENESIS OF LEU-245 AND GLU-250 +DOMAIN + + + + +Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase. + + + + + + + + + + + + + + + + +MECHANISM OF FREE RADICAL-INDUCED AGGREGATION +ACTIVE SITE +OXIDATION AT MET-46 + +MUTAGENESIS OF MET-46; MET-105; CYS-152; CYS-156; TRP-196; CYS-247 AND TYR-320 + + + + + +An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. + + + + + + + + + + + + + + + + + +PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-177; THR-182; THR-184 AND SER-241 + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + +Liver + + + + + +N-terminome analysis of the human mitochondrial proteome. + + + + + + + + + + + + + + + + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + + + + +Citrobacter rodentium NleB protein inhibits tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) ubiquitination to reduce host type I interferon production. + + + + + + + + + + + + + + + +FUNCTION +GLYCOSYLATION (MICROBIAL INFECTION) +INTERACTION WITH TRAF2 +MUTAGENESIS OF CYS-152 + + + + +NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity. + + + + + + + + + + + + + + + +GLYCOSYLATION AT ARG-197 AND ARG-200 (MICROBIAL INFECTION) + + + + + +Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. + + + + + + + + + + + + +SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-186 + +IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] + + + + + +Twinning in crystals of human skeletal muscle D-glyceraldehyde-3-phosphate dehydrogenase. + + + + + + + + + +X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) + + + + +Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. + + + + + + + + + +X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH NAD + +SUBUNIT + + + + +High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase. + + + + + + + + + +X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH NAD + +SUBUNIT + + + +Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:3170585, PubMed:11724794). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:3170585, PubMed:11724794). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). + + + + + +D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH + + + + + + + + + + + + + + +L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein] + + + + + + + + + + + + + + + +Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues. + + + + +Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. + + + + +Homotetramer (PubMed:16239728, PubMed:16510976). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation (By similarity). Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation (By similarity). Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules (By similarity). Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1 (PubMed:11724794, PubMed:16501887, PubMed:15628863, PubMed:20644585). Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:22771119). Component of the GAIT complex (PubMed:15479637). Interacts with FKBP6; leading to inhibit GAPDH catalytic activity (PubMed:19001379). Interacts with TRAF2, promoting TRAF2 ubiquitination (PubMed:23332158). Interacts with TRAF3, promoting TRAF3 ubiquitination (PubMed:27387501). + + + + +P04406 + + +Q6UY14-3 + + +false +3 + + + +P04406 + + +Q9UIJ7 + + +false +3 + + + +P04406 + + +P05067 + + +false +3 + + + +P04406 + + +Q9UQM7 + + +false +3 + + + +P04406 + + +Q14194 + + +false +3 + + + +P04406 + + +P35222 + + +false +3 + + + +P04406 + + +Q9BPW9-4 + + +false +3 + + + +P04406 + + +P00533 + + +false +7 + + + +P04406 + + +O00471 + + +false +3 + + + +P04406 + + +O75344 + + +false +3 + + + +P04406 + + +P06241 + + +false +3 + + + +P04406 + + +P04406 + + +false +2 + + + +P04406 + + +Q8NEA9 + + +false +3 + + + +P04406 + + +P42858 + + +false +7 + + + +P04406 + + +Q92993-2 + + +false +3 + + + +P04406 + + +P42695 + + +false +2 + + + +P04406 + + +P35228 + + +false +8 + + + +P04406 + + +P12004 + + +false +3 + + + +P04406 + + +P00558 + + +false +2 + + + +P04406 + + +P48147 + + +false +5 + + + +P04406 + + +P17612 + + +false +3 + + + +P04406 + + +Q8WUY3 + + +false +3 + + + +P04406 + + +Q9UHX1-2 + + +false +3 + + + +P04406 + + +P15927 + + +false +2 + + + +P04406 + + +P05109 + + +false +6 + + + +P04406 + + +Q96GZ6 + + +false +3 + + + +P04406 + + +P00441 + + +false +3 + + + +P04406 + + +Q9BSI4 + + +false +2 + + + +P04406 + + +P10599 + + +false +3 + + + +Cytoplasm +Cytosol + + +Nucleus + + +Cytoplasm +Perinuclear region + + +Membrane + + +Cytoplasm +Cytoskeleton + + +Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions (PubMed:12829261). + + + + + +P04406-1 +1 + + + +P04406-2 +2 + + + + + +The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex. + + + + +S-nitrosylation of Cys-152 leads to interaction with SIAH1, followed by translocation to the nucleus (By similarity). S-nitrosylation of Cys-247 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (PubMed:22771119, PubMed:25417112). + + + +ISGylated. + + + +Sulfhydration at Cys-152 increases catalytic activity. + + + + +Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation. Such aggregates can be observed in vivo in the affected tissues of patients with Alzheimer disease or alcoholic liver cirrhosis, or in cell cultures during necrosis. Oxidation at Met-46 may play a pivotal role in the formation of these insoluble structures. This modification has been detected in vitro following treatment with free radical donor (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide. It has been proposed to destabilize nearby residues, increasing the likelihood of secondary oxidative damages, including oxidation of Tyr-45 and Met-105. This cascade of oxidations may augment GAPDH misfolding, leading to intermolecular disulfide cross-linking and aggregation. + + + + +Succination of Cys-152 and Cys-247 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits glyceraldehyde-3-phosphate dehydrogenase activity. Fumarate concentration as well as succination of cysteine residues in GAPDH is significantly increased in muscle of diabetic mammals. It was proposed that the S-(2-succinyl)cysteine chemical modification may be a useful biomarker of mitochondrial and oxidative stress in diabetes and that succination of GAPDH and other thiol proteins by fumarate may contribute to the metabolic changes underlying the development of diabetes complications. + + + + +(Microbial infection) Glycosylated by C.rodentium protein NleB, enteropathogenic E.coli protein NleB1 and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents the interaction with TRAF2 and TRAF3 (PubMed:23332158, PubMed:27387501, PubMed:28522607). This leads to reduced ubiquitination of TRAF2 and TRAF3, and subsequent inhibition of NF-kappa-B signaling and type I interferon production, respectively (PubMed:23332158, PubMed:27387501). + + + + +Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. + + + + + + + +Glyceraldehyde 3-phosphate dehydrogenase entry + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +3D-structure +Acetylation +ADP-ribosylation +Alternative splicing +Apoptosis +Cytoplasm +Cytoskeleton +Direct protein sequencing +Glycolysis +Glycoprotein +Immunity +Innate immunity +Isopeptide bond +Membrane +Methylation +NAD +Nucleus +Oxidation +Oxidoreductase +Phosphoprotein +Reference proteome +S-nitrosylation +Transferase +Translation regulation +Ubl conjugation + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +NAD(+) + + + + + + + + +NAD(+) + + + + + + + + +NAD(+) + + + + + + + + +NAD(+) + + + + + + + + + +D-glyceraldehyde 3-phosphate + + + + + + + + +D-glyceraldehyde 3-phosphate + + + + + + + + + +D-glyceraldehyde 3-phosphate + + + + + + + + +D-glyceraldehyde 3-phosphate + + + + + + + + +NAD(+) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +A +G + + + + + +K +N + + + + + +M +L + + + + + +M +L + + + + + +C +S + + + + + +C +S + + + + + +W +F + + + + + +T +A + + + + + +T +A + + + + + +S +A + + + + + +L +M + + + + + +T +A + + + + + +C +S + + + + + +E +M + + + + + +T +A + + + + + +Y +F + + + + + +N +D + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE + + + +Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License + + \ No newline at end of file diff --git a/mzLib/Test/Test.csproj b/mzLib/Test/Test.csproj index e19ce89b8..9ff3defc6 100644 --- a/mzLib/Test/Test.csproj +++ b/mzLib/Test/Test.csproj @@ -84,12 +84,21 @@ Always + + Always + + + Always + Always Always + + Always + Always diff --git a/mzLib/Test/TestPeptideWithSetMods.cs b/mzLib/Test/TestPeptideWithSetMods.cs index 1829f7820..42e81fbe5 100644 --- a/mzLib/Test/TestPeptideWithSetMods.cs +++ b/mzLib/Test/TestPeptideWithSetMods.cs @@ -1085,5 +1085,37 @@ public static void CheckMostAbundantMonoisotopicMass() double large_pep_most_abundant_mass_prospector = 4709.12020 - 1.0079; Assert.That(large_pep.MostAbundantMonoisotopicMass, Is.EqualTo(large_pep_most_abundant_mass_prospector).Within(0.01)); } + + [Test] + public static void TestPeptideWithSetModsFullSequence() + { + var psiModDeserialized = Loaders.LoadPsiMod(Path.Combine(TestContext.CurrentContext.TestDirectory, "PSI-MOD.obo2.xml")); + Dictionary formalChargesDictionary = Loaders.GetFormalChargesDictionary(psiModDeserialized); + List UniProtPtms = Loaders.LoadUniprot(Path.Combine(TestContext.CurrentContext.TestDirectory, "ptmlist2.txt"), formalChargesDictionary).ToList(); + var proteinXml = ProteinDbLoader.LoadProteinXML(Path.Combine(TestContext.CurrentContext.TestDirectory, "DatabaseTests", "humanGAPDH.xml"), true, DecoyType.None, UniProtPtms, false, null, out var unknownMod); + var gapdh = proteinXml[0]; + + var gapdhPeptides = gapdh.Digest(new DigestionParams(maxMissedCleavages:0, minPeptideLength:1, initiatorMethionineBehavior:InitiatorMethionineBehavior.Variable),UniProtPtms,new List()); + + List allSequences = new List(); + foreach (var peptide in gapdhPeptides) + { + allSequences.Add(peptide.FullSequence); + } + + var expectedFullStrings = File.ReadAllLines(Path.Combine(TestContext.CurrentContext.TestDirectory, "DatabaseTests", "fullSequences.txt")); + CollectionAssert.AreEquivalent(expectedFullStrings,allSequences.ToArray()); + + allSequences.Clear(); + foreach (var peptide in gapdhPeptides) + { + allSequences.Add(peptide.FullSequenceWithMassShift()); + } + File.WriteAllLines(@"E:\junk\fullSequencesWithMassShift.txt", allSequences); + var expectedFullStringsWithMassShifts = File.ReadAllLines(Path.Combine(TestContext.CurrentContext.TestDirectory, "DatabaseTests", "fullSequencesWithMassShift.txt")); + CollectionAssert.AreEquivalent(expectedFullStringsWithMassShifts, allSequences.ToArray()); + + + } } } \ No newline at end of file From 9134d17928d841decea2719a276602f318d7506a Mon Sep 17 00:00:00 2001 From: Michael Shortreed Date: Mon, 14 Aug 2023 13:56:33 -0500 Subject: [PATCH 06/11] afds --- .../ProteolyticDigestion/PeptideWithSetModifications.cs | 8 +++++++- 1 file changed, 7 insertions(+), 1 deletion(-) diff --git a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs index fc10f13d2..cf0b5ce95 100644 --- a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs +++ b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs @@ -1095,7 +1095,13 @@ private void DetermineFullSequence() FullSequence = subsequence.ToString(); } - + /// + /// This method returns the full sequence with mass shifts INSTEAD OF PTMs in brackets [] + /// Some external tools cannot parse PTMs, instead requiring a numerical input indicating the mass of a PTM in brackets + /// after the position of that modification + /// N-terminal mas shifts are in brackets prior to the first amino acid and apparently missing the + sign + /// + /// private string DetermineFullSequenceWithMassShifts() { var subsequence = new StringBuilder(); From 3342b3112f41318bd3e3fe871a6201fb9008c98e Mon Sep 17 00:00:00 2001 From: Michael Shortreed Date: Tue, 15 Aug 2023 10:14:55 -0500 Subject: [PATCH 07/11] nuthin --- .../ProteolyticDigestion/PeptideWithSetModifications.cs | 1 - 1 file changed, 1 deletion(-) diff --git a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs index cf0b5ce95..f58617517 100644 --- a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs +++ b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs @@ -1143,7 +1143,6 @@ private string DetermineFullSequenceWithMassShifts() subsequence.Append("[" + mod.MonoisotopicMass.ToString() + ']'); } } - return subsequence.ToString(); } From b3a780b41331999e2cbcc2640a1f2d5f71effec7 Mon Sep 17 00:00:00 2001 From: Michael Shortreed Date: Tue, 15 Aug 2023 10:36:59 -0500 Subject: [PATCH 08/11] deleted path to hd --- .../ProteolyticDigestion/PeptideWithSetModifications.cs | 2 -- mzLib/Test/TestPeptideWithSetMods.cs | 2 +- 2 files changed, 1 insertion(+), 3 deletions(-) diff --git a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs index f58617517..163904eaa 100644 --- a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs +++ b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs @@ -1040,7 +1040,6 @@ private void GetProteinAfterDeserialization(Dictionary idToProt { throw new MzLibUtil.MzLibException("Could not find protein accession after deserialization! " + ProteinAccession); } - Protein = protein; } @@ -1127,7 +1126,6 @@ private string DetermineFullSequenceWithMassShifts() { subsequence.Append("[" + mod.MonoisotopicMass.ToString() + ']'); } - } } diff --git a/mzLib/Test/TestPeptideWithSetMods.cs b/mzLib/Test/TestPeptideWithSetMods.cs index 42e81fbe5..a32e53d64 100644 --- a/mzLib/Test/TestPeptideWithSetMods.cs +++ b/mzLib/Test/TestPeptideWithSetMods.cs @@ -1111,7 +1111,7 @@ public static void TestPeptideWithSetModsFullSequence() { allSequences.Add(peptide.FullSequenceWithMassShift()); } - File.WriteAllLines(@"E:\junk\fullSequencesWithMassShift.txt", allSequences); + //File.WriteAllLines(@"E:\junk\fullSequencesWithMassShift.txt", allSequences); var expectedFullStringsWithMassShifts = File.ReadAllLines(Path.Combine(TestContext.CurrentContext.TestDirectory, "DatabaseTests", "fullSequencesWithMassShift.txt")); CollectionAssert.AreEquivalent(expectedFullStringsWithMassShifts, allSequences.ToArray()); From ac7e447755c2483cca828b5ed58c402924818b61 Mon Sep 17 00:00:00 2001 From: Michael Shortreed Date: Tue, 15 Aug 2023 10:37:16 -0500 Subject: [PATCH 09/11] f --- mzLib/Test/TestPeptideWithSetMods.cs | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/mzLib/Test/TestPeptideWithSetMods.cs b/mzLib/Test/TestPeptideWithSetMods.cs index a32e53d64..1153a393e 100644 --- a/mzLib/Test/TestPeptideWithSetMods.cs +++ b/mzLib/Test/TestPeptideWithSetMods.cs @@ -1111,7 +1111,7 @@ public static void TestPeptideWithSetModsFullSequence() { allSequences.Add(peptide.FullSequenceWithMassShift()); } - //File.WriteAllLines(@"E:\junk\fullSequencesWithMassShift.txt", allSequences); + var expectedFullStringsWithMassShifts = File.ReadAllLines(Path.Combine(TestContext.CurrentContext.TestDirectory, "DatabaseTests", "fullSequencesWithMassShift.txt")); CollectionAssert.AreEquivalent(expectedFullStringsWithMassShifts, allSequences.ToArray()); From c7508b9a704174be24c88dff9bb5de029534d2b3 Mon Sep 17 00:00:00 2001 From: Michael Shortreed Date: Tue, 15 Aug 2023 11:21:02 -0500 Subject: [PATCH 10/11] test essential sequence in peptideWithSetMods --- .../Test/DatabaseTests/essentialSequences.txt | 134 ++++++++++++++++++ mzLib/Test/Test.csproj | 3 + mzLib/Test/TestPeptideWithSetMods.cs | 26 +++- 3 files changed, 161 insertions(+), 2 deletions(-) create mode 100644 mzLib/Test/DatabaseTests/essentialSequences.txt diff --git a/mzLib/Test/DatabaseTests/essentialSequences.txt b/mzLib/Test/DatabaseTests/essentialSequences.txt new file mode 100644 index 000000000..a7061f007 --- /dev/null +++ b/mzLib/Test/DatabaseTests/essentialSequences.txt @@ -0,0 +1,134 @@ +[UniProt:N-methylmethionine on M]M[UniProt:S-methylmethionine on M]GK[UniProt:O-linked (Hex) hydroxylysine on K] +[UniProt:N-palmitoyl glycine on G]GK[UniProt:O-linked (Hex) hydroxylysine on K] +[UniProt:N-acetylglycine on G]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]K[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]GV[UniProt:N-methylvaline on V]N[UniProt:N-linked (HexNAc) asparagine on N]GF[UniProt:3-hydroxyphenylalanine on F]GR[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]GV[UniProt:N-methylvaline on V]N[UniProt:Deamidated asparagine on N]GF[UniProt:3-hydroxyphenylalanine on F]GR[UniProt:N-linked (HexNAc) arginine on R] +I[UniProt:N-methylisoleucine on I]GR[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]T[UniProt:O-linked (HexNAc) threonine on T]R[UniProt:N-linked (HexNAc) arginine on R] +AAF[UniProt:3-hydroxyphenylalanine on F]N[UniProt:N-linked (HexNAc) asparagine on N]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]AI[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]F[UniProt:3-hydroxyphenylalanine on F]I[UniProt:N-methylisoleucine on I]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:S-methylmethionine on M]V[UniProt:N-methylvaline on V]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:S-methylmethionine on M]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]AI[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]F[UniProt:3-hydroxyphenylalanine on F]I[UniProt:N-methylisoleucine on I]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:S-methylmethionine on M]V[UniProt:N-methylvaline on V]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:Methionine sulfoxide on M]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]AI[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]F[UniProt:3-hydroxyphenylalanine on F]I[UniProt:N-methylisoleucine on I]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]Y[UniProt:Phosphotyrosine on Y]M[UniProt:S-methylmethionine on M]V[UniProt:N-methylvaline on V]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:S-methylmethionine on M]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]AI[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]F[UniProt:3-hydroxyphenylalanine on F]I[UniProt:N-methylisoleucine on I]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]Y[UniProt:Phosphotyrosine on Y]M[UniProt:S-methylmethionine on M]V[UniProt:N-methylvaline on V]Y[UniProt:O-linked (HexNAc) tyrosine on Y]M[UniProt:Methionine sulfoxide on M]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]GK[UniProt:O-linked (Hex) hydroxylysine on K] +F[UniProt:3-hydroxyphenylalanine on F]H[UniProt:N-linked (Glc) (glycation) histidine on H]GT[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]K[UniProt:O-linked (Hex) hydroxylysine on K] +F[UniProt:3-hydroxyphenylalanine on F]H[UniProt:N-linked (Glc) (glycation) histidine on H]GT[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]K[UniProt:N6-acetyllysine on K] +AE[UniProt:Glutamate methyl ester (Glu) on E]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:O-linked (Hex) hydroxylysine on K] +AE[UniProt:Glutamate methyl ester (Glu) on E]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:N6,N6-dimethyllysine on K] +AE[UniProt:Glutamate methyl ester (Glu) on E]N[UniProt:Deamidated asparagine on N]GK[UniProt:O-linked (Hex) hydroxylysine on K] +AE[UniProt:Glutamate methyl ester (Glu) on E]N[UniProt:Deamidated asparagine on N]GK[UniProt:N6,N6-dimethyllysine on K] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]GN[UniProt:N-linked (HexNAc) asparagine on N]P[UniProt:O-linked (HexNAc) hydroxyproline on P]I[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]I[UniProt:N-methylisoleucine on I]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]E[UniProt:Glutamate methyl ester (Glu) on E]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]N[UniProt:N-linked (HexNAc) asparagine on N]GN[UniProt:N-linked (HexNAc) asparagine on N]P[UniProt:O-linked (HexNAc) hydroxyproline on P]I[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]I[UniProt:N-methylisoleucine on I]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]E[UniProt:Glutamate methyl ester (Glu) on E]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]N[UniProt:Deamidated asparagine on N]GN[UniProt:N-linked (HexNAc) asparagine on N]P[UniProt:O-linked (HexNAc) hydroxyproline on P]I[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]I[UniProt:N-methylisoleucine on I]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]E[UniProt:Glutamate methyl ester (Glu) on E]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]N[UniProt:Deamidated asparagine on N]GN[UniProt:N-linked (HexNAc) asparagine on N]P[UniProt:O-linked (HexNAc) hydroxyproline on P]I[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]I[UniProt:N-methylisoleucine on I]F[UniProt:3-hydroxyphenylalanine on F]Q[UniProt:5-glutamyl serotonin on Q]E[UniProt:Glutamate methyl ester (Glu) on E]R[UniProt:N-linked (HexNAc) arginine on R] +D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]K[UniProt:O-linked (Hex) hydroxylysine on K] +D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]P[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:Phosphoserine on S]K[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]K[UniProt:O-linked (Hex) hydroxylysine on K] +W[UniProt:N-linked (Hex) tryptophan on W]GD[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]AGAE[UniProt:Glutamate methyl ester (Glu) on E]Y[UniProt:O-linked (HexNAc) tyrosine on Y]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]GV[UniProt:N-methylvaline on V]F[UniProt:3-hydroxyphenylalanine on F]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]M[UniProt:S-methylmethionine on M]E[UniProt:Glutamate methyl ester (Glu) on E]K[UniProt:O-linked (Hex) hydroxylysine on K] +AGAH[UniProt:N-linked (Glc) (glycation) histidine on H]L[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]GGAK[UniProt:O-linked (Hex) hydroxylysine on K] +R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]AD[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]M[UniProt:S-methylmethionine on M]F[UniProt:3-hydroxyphenylalanine on F]V[UniProt:N-methylvaline on V]M[UniProt:S-methylmethionine on M]GV[UniProt:N-methylvaline on V]N[UniProt:N-linked (HexNAc) asparagine on N]H[UniProt:N-linked (Glc) (glycation) histidine on H]E[UniProt:Glutamate methyl ester (Glu) on E]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]AD[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]M[UniProt:S-methylmethionine on M]F[UniProt:3-hydroxyphenylalanine on F]V[UniProt:N-methylvaline on V]M[UniProt:S-methylmethionine on M]GV[UniProt:N-methylvaline on V]N[UniProt:N-linked (HexNAc) asparagine on N]H[UniProt:N-linked (Glc) (glycation) histidine on H]E[UniProt:Glutamate methyl ester (Glu) on E]K[UniProt:O-linked (Hex) hydroxylysine on K] +Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]S[UniProt:O-linked (HexNAc) serine on S]L[UniProt:(4R)-5-oxoleucine on L]K[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:Deamidated asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:Phosphothreonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:ADP-ribosylcysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:Cysteine persulfide on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-(2-succinyl)cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-nitrosocysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:N-linked (HexNAc) asparagine on N]AS[UniProt:Phosphoserine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]N[UniProt:Deamidated asparagine on N]AS[UniProt:O-linked (HexNAc) serine on S]C[UniProt:S-linked (HexNAc) cysteine on C]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]N[UniProt:N-linked (HexNAc) asparagine on N]C[UniProt:S-linked (HexNAc) cysteine on C]L[UniProt:(4R)-5-oxoleucine on L]AP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]AK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]AT[UniProt:O-linked (HexNAc) threonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]AT[UniProt:Phosphothreonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]AT[UniProt:O-linked (HexNAc) threonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:Phosphothreonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]AT[UniProt:O-linked (HexNAc) threonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]AT[UniProt:Phosphothreonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:Phosphothreonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:O-linked (HexNAc) threonine on T]AT[UniProt:Phosphothreonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]H[UniProt:N-linked (Glc) (glycation) histidine on H]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]F[UniProt:3-hydroxyphenylalanine on F]GI[UniProt:N-methylisoleucine on I]V[UniProt:N-methylvaline on V]E[UniProt:Glutamate methyl ester (Glu) on E]GL[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]T[UniProt:O-linked (HexNAc) threonine on T]T[UniProt:Phosphothreonine on T]V[UniProt:N-methylvaline on V]H[UniProt:N-linked (Glc) (glycation) histidine on H]AI[UniProt:N-methylisoleucine on I]T[UniProt:Phosphothreonine on T]AT[UniProt:O-linked (HexNAc) threonine on T]Q[UniProt:5-glutamyl serotonin on Q]K[UniProt:O-linked (Hex) hydroxylysine on K] +T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:O-linked (Hex) hydroxylysine on K] +T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:N6,N6-dimethyllysine on K] +T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:N6-acetyllysine on K] +T[UniProt:O-linked (HexNAc) threonine on T]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]S[UniProt:O-linked (HexNAc) serine on S]GK[UniProt:N6-malonyllysine on K] +L[UniProt:(4R)-5-oxoleucine on L]W[UniProt:N-linked (Hex) tryptophan on W]R[UniProt:N-linked (HexNAc) arginine on R] +D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]GR[UniProt:N-linked (HexNAc) arginine on R] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]GAAK[UniProt:O-linked (Hex) hydroxylysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]GAAK[UniProt:N6,N6-dimethyllysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]GAAK[UniProt:N6-malonyllysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:Phosphothreonine on T]GAAK[UniProt:O-linked (Hex) hydroxylysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:Phosphothreonine on T]GAAK[UniProt:N6,N6-dimethyllysine on K] +GAL[UniProt:(4R)-5-oxoleucine on L]Q[UniProt:5-glutamyl serotonin on Q]N[UniProt:N-linked (HexNAc) asparagine on N]I[UniProt:N-methylisoleucine on I]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]AS[UniProt:O-linked (HexNAc) serine on S]T[UniProt:Phosphothreonine on T]GAAK[UniProt:N6-malonyllysine on K] +AV[UniProt:N-methylvaline on V]GK[UniProt:O-linked (Hex) hydroxylysine on K] +AV[UniProt:N-methylvaline on V]GK[UniProt:N6-acetyllysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]GK[UniProt:N6-acetyllysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:Deamidated asparagine on N]GK[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:Deamidated asparagine on N]GK[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]I[UniProt:N-methylisoleucine on I]P[UniProt:O-linked (HexNAc) hydroxyproline on P]E[UniProt:Glutamate methyl ester (Glu) on E]L[UniProt:(4R)-5-oxoleucine on L]N[UniProt:Deamidated asparagine on N]GK[UniProt:N6-acetyllysine on K] +L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]GM[UniProt:S-methylmethionine on M]AF[UniProt:3-hydroxyphenylalanine on F]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:Phosphothreonine on T]GM[UniProt:S-methylmethionine on M]AF[UniProt:3-hydroxyphenylalanine on F]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-linked (HexNAc) cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-(2-succinyl)cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-nitrosocysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:Phosphoserine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-linked (HexNAc) cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:Phosphothreonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-linked (HexNAc) cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:Phosphoserine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-(2-succinyl)cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:O-linked (HexNAc) threonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:Phosphoserine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-nitrosocysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:Phosphothreonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-(2-succinyl)cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:Phosphothreonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-nitrosocysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]P[UniProt:O-linked (HexNAc) hydroxyproline on P]T[UniProt:Phosphothreonine on T]AN[UniProt:N-linked (HexNAc) asparagine on N]V[UniProt:N-methylvaline on V]S[UniProt:Phosphoserine on S]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]T[UniProt:O-linked (HexNAc) threonine on T]C[UniProt:S-linked (HexNAc) cysteine on C]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]E[UniProt:Glutamate methyl ester (Glu) on E]K[UniProt:O-linked (Hex) hydroxylysine on K] +P[UniProt:O-linked (HexNAc) hydroxyproline on P]AK[UniProt:O-linked (Hex) hydroxylysine on K] +P[UniProt:O-linked (HexNAc) hydroxyproline on P]AK[UniProt:N6-acetyllysine on K] +Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]I[UniProt:N-methylisoleucine on I]K[UniProt:O-linked (Hex) hydroxylysine on K] +K[UniProt:O-linked (Hex) hydroxylysine on K] +K[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]K[UniProt:N6,N6-dimethyllysine on K] +Q[UniProt:5-glutamyl serotonin on Q]AS[UniProt:O-linked (HexNAc) serine on S]E[UniProt:Glutamate methyl ester (Glu) on E]GP[UniProt:O-linked (HexNAc) hydroxyproline on P]L[UniProt:(4R)-5-oxoleucine on L]K[UniProt:O-linked (Hex) hydroxylysine on K] +GI[UniProt:N-methylisoleucine on I]L[UniProt:(4R)-5-oxoleucine on L]GY[UniProt:O-linked (HexNAc) tyrosine on Y]T[UniProt:O-linked (HexNAc) threonine on T]E[UniProt:Glutamate methyl ester (Glu) on E]H[UniProt:N-linked (Glc) (glycation) histidine on H]Q[UniProt:5-glutamyl serotonin on Q]V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]S[UniProt:O-linked (HexNAc) serine on S]S[UniProt:O-linked (HexNAc) serine on S]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]F[UniProt:3-hydroxyphenylalanine on F]N[UniProt:N-linked (HexNAc) asparagine on N]S[UniProt:O-linked (HexNAc) serine on S]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]T[UniProt:O-linked (HexNAc) threonine on T]H[UniProt:N-linked (Glc) (glycation) histidine on H]S[UniProt:O-linked (HexNAc) serine on S]S[UniProt:O-linked (HexNAc) serine on S]T[UniProt:O-linked (HexNAc) threonine on T]F[UniProt:3-hydroxyphenylalanine on F]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]AGAGI[UniProt:N-methylisoleucine on I]AL[UniProt:(4R)-5-oxoleucine on L]N[UniProt:N-linked (HexNAc) asparagine on N]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]H[UniProt:N-linked (Glc) (glycation) histidine on H]F[UniProt:3-hydroxyphenylalanine on F]V[UniProt:N-methylvaline on V]K[UniProt:O-linked (Hex) hydroxylysine on K] +L[UniProt:(4R)-5-oxoleucine on L]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]W[UniProt:N-linked (Hex) tryptophan on W]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]E[UniProt:Glutamate methyl ester (Glu) on E]F[UniProt:3-hydroxyphenylalanine on F]GY[UniProt:O-linked (HexNAc) tyrosine on Y]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]I[UniProt:N-methylisoleucine on I]S[UniProt:O-linked (HexNAc) serine on S]W[UniProt:N-linked (Hex) tryptophan on W]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:Deamidated asparagine on N]E[UniProt:Glutamate methyl ester (Glu) on E]F[UniProt:3-hydroxyphenylalanine on F]GY[UniProt:O-linked (HexNAc) tyrosine on Y]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]W[UniProt:N-linked (Hex) tryptophan on W]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:N-linked (HexNAc) asparagine on N]E[UniProt:Glutamate methyl ester (Glu) on E]F[UniProt:3-hydroxyphenylalanine on F]GY[UniProt:O-linked (HexNAc) tyrosine on Y]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]R[UniProt:N-linked (HexNAc) arginine on R] +L[UniProt:(4R)-5-oxoleucine on L]I[UniProt:N-methylisoleucine on I]S[UniProt:Phosphoserine on S]W[UniProt:N-linked (Hex) tryptophan on W]Y[UniProt:O-linked (HexNAc) tyrosine on Y]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]N[UniProt:Deamidated asparagine on N]E[UniProt:Glutamate methyl ester (Glu) on E]F[UniProt:3-hydroxyphenylalanine on F]GY[UniProt:O-linked (HexNAc) tyrosine on Y]S[UniProt:O-linked (HexNAc) serine on S]N[UniProt:N-linked (HexNAc) asparagine on N]R[UniProt:N-linked (HexNAc) arginine on R] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]AH[UniProt:N-linked (Glc) (glycation) histidine on H]M[UniProt:S-methylmethionine on M]AS[UniProt:O-linked (HexNAc) serine on S]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]AH[UniProt:N-linked (Glc) (glycation) histidine on H]M[UniProt:S-methylmethionine on M]AS[UniProt:O-linked (HexNAc) serine on S]K[UniProt:N6,N6-dimethyllysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]AH[UniProt:N-linked (Glc) (glycation) histidine on H]M[UniProt:S-methylmethionine on M]AS[UniProt:Phosphoserine on S]K[UniProt:O-linked (Hex) hydroxylysine on K] +V[UniProt:N-methylvaline on V]V[UniProt:N-methylvaline on V]D[UniProt:Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester on D]L[UniProt:(4R)-5-oxoleucine on L]M[UniProt:S-methylmethionine on M]AH[UniProt:N-linked (Glc) (glycation) histidine on H]M[UniProt:S-methylmethionine on M]AS[UniProt:Phosphoserine on S]K[UniProt:N6,N6-dimethyllysine on K] +E[UniProt:Glutamate methyl ester (Glu) on E][UniProt:Glutamic acid 1-amide on E] +E[UniProt:Glutamate methyl ester (Glu) on E][UniProt:5-glutamyl 2-aminoadipic acid on E] +[UniProt:N-palmitoyl glycine on G]GK[UniProt:O-linked (Hex) hydroxylysine on K] +[UniProt:N-acetylglycine on G]GK[UniProt:O-linked (Hex) hydroxylysine on K] diff --git a/mzLib/Test/Test.csproj b/mzLib/Test/Test.csproj index 1f19dd4a7..29a7964d4 100644 --- a/mzLib/Test/Test.csproj +++ b/mzLib/Test/Test.csproj @@ -78,6 +78,9 @@ Always + + Always + Always diff --git a/mzLib/Test/TestPeptideWithSetMods.cs b/mzLib/Test/TestPeptideWithSetMods.cs index 1153a393e..dcdd731d3 100644 --- a/mzLib/Test/TestPeptideWithSetMods.cs +++ b/mzLib/Test/TestPeptideWithSetMods.cs @@ -1086,6 +1086,30 @@ public static void CheckMostAbundantMonoisotopicMass() Assert.That(large_pep.MostAbundantMonoisotopicMass, Is.EqualTo(large_pep_most_abundant_mass_prospector).Within(0.01)); } + [Test] + public static void TestPeptideWithSetModsEssentialSequence() + { + var psiModDeserialized = Loaders.LoadPsiMod(Path.Combine(TestContext.CurrentContext.TestDirectory, "PSI-MOD.obo2.xml")); + Dictionary formalChargesDictionary = Loaders.GetFormalChargesDictionary(psiModDeserialized); + List UniProtPtms = Loaders.LoadUniprot(Path.Combine(TestContext.CurrentContext.TestDirectory, "ptmlist2.txt"), formalChargesDictionary).ToList(); + + Dictionary modsToWrite = new Dictionary(); + modsToWrite.Add("UniProt",0); + + var proteinXml = ProteinDbLoader.LoadProteinXML(Path.Combine(TestContext.CurrentContext.TestDirectory, "DatabaseTests", "humanGAPDH.xml"), true, DecoyType.None, UniProtPtms, false, null, out var unknownMod); + var gapdh = proteinXml[0]; + + var gapdhPeptides = gapdh.Digest(new DigestionParams(maxMissedCleavages: 0, minPeptideLength: 1, initiatorMethionineBehavior: InitiatorMethionineBehavior.Variable), UniProtPtms, new List()); + + List allSequences = new List(); + foreach (var peptide in gapdhPeptides) + { + allSequences.Add(peptide.EssentialSequence(modsToWrite)); + } + + var expectedFullStrings = File.ReadAllLines(Path.Combine(TestContext.CurrentContext.TestDirectory, "DatabaseTests", "essentialSequences.txt")); + CollectionAssert.AreEquivalent(expectedFullStrings, allSequences.ToArray()); + } [Test] public static void TestPeptideWithSetModsFullSequence() { @@ -1114,8 +1138,6 @@ public static void TestPeptideWithSetModsFullSequence() var expectedFullStringsWithMassShifts = File.ReadAllLines(Path.Combine(TestContext.CurrentContext.TestDirectory, "DatabaseTests", "fullSequencesWithMassShift.txt")); CollectionAssert.AreEquivalent(expectedFullStringsWithMassShifts, allSequences.ToArray()); - - } } } \ No newline at end of file From b62ce790b3b9a7f48568209538cc5311b27be1e5 Mon Sep 17 00:00:00 2001 From: Michael Shortreed Date: Tue, 15 Aug 2023 14:27:13 -0500 Subject: [PATCH 11/11] fixed mod sig figs to six --- .../PeptideWithSetModifications.cs | 10 ++--- .../fullSequencesWithMassShift.txt | 42 +++++++++---------- 2 files changed, 26 insertions(+), 26 deletions(-) diff --git a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs index 163904eaa..067afb849 100644 --- a/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs +++ b/mzLib/Proteomics/ProteolyticDigestion/PeptideWithSetModifications.cs @@ -1108,7 +1108,7 @@ private string DetermineFullSequenceWithMassShifts() // modification on peptide N-terminus if (AllModsOneIsNterminus.TryGetValue(1, out Modification mod)) { - subsequence.Append('[' + mod.MonoisotopicMass.ToString() + ']'); + subsequence.Append('[' + mod.MonoisotopicMass.RoundedDouble(6).ToString() + ']'); } for (int r = 0; r < Length; r++) @@ -1120,11 +1120,11 @@ private string DetermineFullSequenceWithMassShifts() { if (mod.MonoisotopicMass > 0) { - subsequence.Append("[+" + mod.MonoisotopicMass.ToString() + ']'); + subsequence.Append("[+" + mod.MonoisotopicMass.RoundedDouble(6).ToString() + ']'); } else { - subsequence.Append("[" + mod.MonoisotopicMass.ToString() + ']'); + subsequence.Append("[" + mod.MonoisotopicMass.RoundedDouble(6).ToString() + ']'); } } } @@ -1134,11 +1134,11 @@ private string DetermineFullSequenceWithMassShifts() { if (mod.MonoisotopicMass > 0) { - subsequence.Append("[+" + mod.MonoisotopicMass.ToString() + ']'); + subsequence.Append("[+" + mod.MonoisotopicMass.RoundedDouble(6).ToString() + ']'); } else { - subsequence.Append("[" + mod.MonoisotopicMass.ToString() + ']'); + subsequence.Append("[" + mod.MonoisotopicMass.RoundedDouble(6).ToString() + ']'); } } return subsequence.ToString(); diff --git a/mzLib/Test/DatabaseTests/fullSequencesWithMassShift.txt b/mzLib/Test/DatabaseTests/fullSequencesWithMassShift.txt index 43ff1ca79..68a378066 100644 --- a/mzLib/Test/DatabaseTests/fullSequencesWithMassShift.txt +++ b/mzLib/Test/DatabaseTests/fullSequencesWithMassShift.txt @@ -1,4 +1,4 @@ -[14.01565]M[+14.015650533]GK[+178.047738] +[14.01565]M[+14.015651]GK[+178.047738] [238.229666]GK[+178.047738] [42.010565]GK[+178.047738] V[+14.01565]K[+178.047738] @@ -8,10 +8,10 @@ V[+14.01565]GV[+14.01565]N[+0.984016]GF[+15.994915]GR[+203.079373] I[+14.01565]GR[+203.079373] L[+13.979265]V[+14.01565]T[+203.079373]R[+203.079373] AAF[+15.994915]N[+203.079373]S[+203.079373]GK[+178.047738] -V[+14.01565]D[+294.183109]I[+14.01565]V[+14.01565]AI[+14.01565]N[+203.079373]D[+294.183109]P[+219.074287]F[+15.994915]I[+14.01565]D[+294.183109]L[+13.979265]N[+203.079373]Y[+203.079373]M[+14.015650533]V[+14.01565]Y[+203.079373]M[+14.015650533]F[+15.994915]Q[+159.068414]Y[+203.079373]D[+294.183109]S[+203.079373]T[+203.079373]H[+162.052823]GK[+178.047738] -V[+14.01565]D[+294.183109]I[+14.01565]V[+14.01565]AI[+14.01565]N[+203.079373]D[+294.183109]P[+219.074287]F[+15.994915]I[+14.01565]D[+294.183109]L[+13.979265]N[+203.079373]Y[+203.079373]M[+14.015650533]V[+14.01565]Y[+203.079373]M[+15.994915]F[+15.994915]Q[+159.068414]Y[+203.079373]D[+294.183109]S[+203.079373]T[+203.079373]H[+162.052823]GK[+178.047738] -V[+14.01565]D[+294.183109]I[+14.01565]V[+14.01565]AI[+14.01565]N[+203.079373]D[+294.183109]P[+219.074287]F[+15.994915]I[+14.01565]D[+294.183109]L[+13.979265]N[+203.079373]Y[+79.966331]M[+14.015650533]V[+14.01565]Y[+203.079373]M[+14.015650533]F[+15.994915]Q[+159.068414]Y[+203.079373]D[+294.183109]S[+203.079373]T[+203.079373]H[+162.052823]GK[+178.047738] -V[+14.01565]D[+294.183109]I[+14.01565]V[+14.01565]AI[+14.01565]N[+203.079373]D[+294.183109]P[+219.074287]F[+15.994915]I[+14.01565]D[+294.183109]L[+13.979265]N[+203.079373]Y[+79.966331]M[+14.015650533]V[+14.01565]Y[+203.079373]M[+15.994915]F[+15.994915]Q[+159.068414]Y[+203.079373]D[+294.183109]S[+203.079373]T[+203.079373]H[+162.052823]GK[+178.047738] +V[+14.01565]D[+294.183109]I[+14.01565]V[+14.01565]AI[+14.01565]N[+203.079373]D[+294.183109]P[+219.074287]F[+15.994915]I[+14.01565]D[+294.183109]L[+13.979265]N[+203.079373]Y[+203.079373]M[+14.015651]V[+14.01565]Y[+203.079373]M[+14.015651]F[+15.994915]Q[+159.068414]Y[+203.079373]D[+294.183109]S[+203.079373]T[+203.079373]H[+162.052823]GK[+178.047738] +V[+14.01565]D[+294.183109]I[+14.01565]V[+14.01565]AI[+14.01565]N[+203.079373]D[+294.183109]P[+219.074287]F[+15.994915]I[+14.01565]D[+294.183109]L[+13.979265]N[+203.079373]Y[+203.079373]M[+14.015651]V[+14.01565]Y[+203.079373]M[+15.994915]F[+15.994915]Q[+159.068414]Y[+203.079373]D[+294.183109]S[+203.079373]T[+203.079373]H[+162.052823]GK[+178.047738] +V[+14.01565]D[+294.183109]I[+14.01565]V[+14.01565]AI[+14.01565]N[+203.079373]D[+294.183109]P[+219.074287]F[+15.994915]I[+14.01565]D[+294.183109]L[+13.979265]N[+203.079373]Y[+79.966331]M[+14.015651]V[+14.01565]Y[+203.079373]M[+14.015651]F[+15.994915]Q[+159.068414]Y[+203.079373]D[+294.183109]S[+203.079373]T[+203.079373]H[+162.052823]GK[+178.047738] +V[+14.01565]D[+294.183109]I[+14.01565]V[+14.01565]AI[+14.01565]N[+203.079373]D[+294.183109]P[+219.074287]F[+15.994915]I[+14.01565]D[+294.183109]L[+13.979265]N[+203.079373]Y[+79.966331]M[+14.015651]V[+14.01565]Y[+203.079373]M[+15.994915]F[+15.994915]Q[+159.068414]Y[+203.079373]D[+294.183109]S[+203.079373]T[+203.079373]H[+162.052823]GK[+178.047738] F[+15.994915]H[+162.052823]GT[+203.079373]V[+14.01565]K[+178.047738] F[+15.994915]H[+162.052823]GT[+203.079373]V[+14.01565]K[+42.010565] AE[+14.01565]N[+203.079373]GK[+178.047738] @@ -25,11 +25,11 @@ L[+13.979265]V[+14.01565]I[+14.01565]N[+0.984016]GN[+203.079373]P[+219.074287]I[ D[+294.183109]P[+219.074287]S[+203.079373]K[+178.047738] D[+294.183109]P[+219.074287]S[+79.966331]K[+178.047738] I[+14.01565]K[+178.047738] -W[+162.052823]GD[+294.183109]AGAE[+14.01565]Y[+203.079373]V[+14.01565]V[+14.01565]E[+14.01565]S[+203.079373]T[+203.079373]GV[+14.01565]F[+15.994915]T[+203.079373]T[+203.079373]M[+14.015650533]E[+14.01565]K[+178.047738] +W[+162.052823]GD[+294.183109]AGAE[+14.01565]Y[+203.079373]V[+14.01565]V[+14.01565]E[+14.01565]S[+203.079373]T[+203.079373]GV[+14.01565]F[+15.994915]T[+203.079373]T[+203.079373]M[+14.015651]E[+14.01565]K[+178.047738] AGAH[+162.052823]L[+13.979265]Q[+159.068414]GGAK[+178.047738] R[+203.079373] -V[+14.01565]I[+14.01565]I[+14.01565]S[+203.079373]AP[+219.074287]S[+203.079373]AD[+294.183109]AP[+219.074287]M[+14.015650533]F[+15.994915]V[+14.01565]M[+14.015650533]GV[+14.01565]N[+203.079373]H[+162.052823]E[+14.01565]K[+178.047738] -V[+14.01565]I[+14.01565]I[+14.01565]S[+79.966331]AP[+219.074287]S[+203.079373]AD[+294.183109]AP[+219.074287]M[+14.015650533]F[+15.994915]V[+14.01565]M[+14.015650533]GV[+14.01565]N[+203.079373]H[+162.052823]E[+14.01565]K[+178.047738] +V[+14.01565]I[+14.01565]I[+14.01565]S[+203.079373]AP[+219.074287]S[+203.079373]AD[+294.183109]AP[+219.074287]M[+14.015651]F[+15.994915]V[+14.01565]M[+14.015651]GV[+14.01565]N[+203.079373]H[+162.052823]E[+14.01565]K[+178.047738] +V[+14.01565]I[+14.01565]I[+14.01565]S[+79.966331]AP[+219.074287]S[+203.079373]AD[+294.183109]AP[+219.074287]M[+14.015651]F[+15.994915]V[+14.01565]M[+14.015651]GV[+14.01565]N[+203.079373]H[+162.052823]E[+14.01565]K[+178.047738] Y[+203.079373]D[+294.183109]N[+203.079373]S[+203.079373]L[+13.979265]K[+178.047738] I[+14.01565]I[+14.01565]S[+203.079373]N[+203.079373]AS[+203.079373]C[+203.079373]T[+203.079373]T[+203.079373]N[+203.079373]C[+203.079373]L[+13.979265]AP[+219.074287]L[+13.979265]AK[+178.047738] I[+14.01565]I[+14.01565]S[+203.079373]N[+203.079373]AS[+203.079373]C[+203.079373]T[+203.079373]T[+203.079373]N[+0.984016]C[+203.079373]L[+13.979265]AP[+219.074287]L[+13.979265]AK[+178.047738] @@ -71,13 +71,13 @@ I[+14.01565]I[+14.01565]S[+79.966331]N[+203.079373]AS[+203.079373]C[+116.010959] I[+14.01565]I[+14.01565]S[+79.966331]N[+203.079373]AS[+203.079373]C[+28.990164]T[+203.079373]T[+203.079373]N[+203.079373]C[+203.079373]L[+13.979265]AP[+219.074287]L[+13.979265]AK[+178.047738] I[+14.01565]I[+14.01565]S[+79.966331]N[+203.079373]AS[+79.966331]C[+203.079373]T[+203.079373]T[+203.079373]N[+203.079373]C[+203.079373]L[+13.979265]AP[+219.074287]L[+13.979265]AK[+178.047738] I[+14.01565]I[+14.01565]S[+79.966331]N[+0.984016]AS[+203.079373]C[+203.079373]T[+203.079373]T[+203.079373]N[+203.079373]C[+203.079373]L[+13.979265]AP[+219.074287]L[+13.979265]AK[+178.047738] -V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015650533]T[+203.079373]T[+203.079373]V[+14.01565]H[+162.052823]AI[+14.01565]T[+203.079373]AT[+203.079373]Q[+159.068414]K[+178.047738] -V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015650533]T[+203.079373]T[+203.079373]V[+14.01565]H[+162.052823]AI[+14.01565]T[+203.079373]AT[+79.966331]Q[+159.068414]K[+178.047738] -V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015650533]T[+203.079373]T[+203.079373]V[+14.01565]H[+162.052823]AI[+14.01565]T[+79.966331]AT[+203.079373]Q[+159.068414]K[+178.047738] -V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015650533]T[+203.079373]T[+79.966331]V[+14.01565]H[+162.052823]AI[+14.01565]T[+203.079373]AT[+203.079373]Q[+159.068414]K[+178.047738] -V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015650533]T[+203.079373]T[+203.079373]V[+14.01565]H[+162.052823]AI[+14.01565]T[+79.966331]AT[+79.966331]Q[+159.068414]K[+178.047738] -V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015650533]T[+203.079373]T[+79.966331]V[+14.01565]H[+162.052823]AI[+14.01565]T[+203.079373]AT[+79.966331]Q[+159.068414]K[+178.047738] -V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015650533]T[+203.079373]T[+79.966331]V[+14.01565]H[+162.052823]AI[+14.01565]T[+79.966331]AT[+203.079373]Q[+159.068414]K[+178.047738] +V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015651]T[+203.079373]T[+203.079373]V[+14.01565]H[+162.052823]AI[+14.01565]T[+203.079373]AT[+203.079373]Q[+159.068414]K[+178.047738] +V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015651]T[+203.079373]T[+203.079373]V[+14.01565]H[+162.052823]AI[+14.01565]T[+203.079373]AT[+79.966331]Q[+159.068414]K[+178.047738] +V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015651]T[+203.079373]T[+203.079373]V[+14.01565]H[+162.052823]AI[+14.01565]T[+79.966331]AT[+203.079373]Q[+159.068414]K[+178.047738] +V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015651]T[+203.079373]T[+79.966331]V[+14.01565]H[+162.052823]AI[+14.01565]T[+203.079373]AT[+203.079373]Q[+159.068414]K[+178.047738] +V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015651]T[+203.079373]T[+203.079373]V[+14.01565]H[+162.052823]AI[+14.01565]T[+79.966331]AT[+79.966331]Q[+159.068414]K[+178.047738] +V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015651]T[+203.079373]T[+79.966331]V[+14.01565]H[+162.052823]AI[+14.01565]T[+203.079373]AT[+79.966331]Q[+159.068414]K[+178.047738] +V[+14.01565]I[+14.01565]H[+162.052823]D[+294.183109]N[+203.079373]F[+15.994915]GI[+14.01565]V[+14.01565]E[+14.01565]GL[+13.979265]M[+14.015651]T[+203.079373]T[+79.966331]V[+14.01565]H[+162.052823]AI[+14.01565]T[+79.966331]AT[+203.079373]Q[+159.068414]K[+178.047738] T[+203.079373]V[+14.01565]D[+294.183109]GP[+219.074287]S[+203.079373]GK[+178.047738] T[+203.079373]V[+14.01565]D[+294.183109]GP[+219.074287]S[+203.079373]GK[+28.0313] T[+203.079373]V[+14.01565]D[+294.183109]GP[+219.074287]S[+203.079373]GK[+42.010565] @@ -98,8 +98,8 @@ V[+14.01565]I[+14.01565]P[+219.074287]E[+14.01565]L[+13.979265]N[+203.079373]GK[ V[+14.01565]I[+14.01565]P[+219.074287]E[+14.01565]L[+13.979265]N[+0.984016]GK[+178.047738] V[+14.01565]I[+14.01565]P[+219.074287]E[+14.01565]L[+13.979265]N[+0.984016]GK[+28.0313] V[+14.01565]I[+14.01565]P[+219.074287]E[+14.01565]L[+13.979265]N[+0.984016]GK[+42.010565] -L[+13.979265]T[+203.079373]GM[+14.015650533]AF[+15.994915]R[+203.079373] -L[+13.979265]T[+79.966331]GM[+14.015650533]AF[+15.994915]R[+203.079373] +L[+13.979265]T[+203.079373]GM[+14.015651]AF[+15.994915]R[+203.079373] +L[+13.979265]T[+79.966331]GM[+14.015651]AF[+15.994915]R[+203.079373] V[+14.01565]P[+219.074287]T[+203.079373]AN[+203.079373]V[+14.01565]S[+203.079373]V[+14.01565]V[+14.01565]D[+294.183109]L[+13.979265]T[+203.079373]C[+203.079373]R[+203.079373] V[+14.01565]P[+219.074287]T[+203.079373]AN[+203.079373]V[+14.01565]S[+203.079373]V[+14.01565]V[+14.01565]D[+294.183109]L[+13.979265]T[+203.079373]C[+116.010959]R[+203.079373] V[+14.01565]P[+219.074287]T[+203.079373]AN[+203.079373]V[+14.01565]S[+203.079373]V[+14.01565]V[+14.01565]D[+294.183109]L[+13.979265]T[+203.079373]C[+28.990164]R[+203.079373] @@ -124,10 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