diff --git a/.github/workflows/docker.yml b/.github/workflows/docker.yml
new file mode 100644
index 00000000..4fb15015
--- /dev/null
+++ b/.github/workflows/docker.yml
@@ -0,0 +1,51 @@
+name: Build and Publish ColabFold Docker
+
+on:
+  workflow_dispatch:
+    inputs:
+      colabfold_version:
+        description: 'ColabFold Conda version'
+        required: true
+        type: string
+        default: '1.5.3'
+
+env:
+  REGISTRY: ghcr.io
+  IMAGE_NAME: ${{ github.repository }}
+
+jobs:
+  build-and-push-image:
+    runs-on: ubuntu-latest
+    strategy:
+        matrix:
+          cuda_version: ["11.8.0", "12.2.2"]
+    permissions:
+      contents: read
+      packages: write
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v3
+
+      - name: Set up Docker Buildx
+        uses: docker/setup-buildx-action@v2
+
+      - name: Log in to the Container registry
+        uses: docker/login-action@f054a8b539a109f9f41c372932f1ae047eff08c9
+        with:
+          registry: ${{ env.REGISTRY }}
+          username: ${{ github.actor }}
+          password: ${{ secrets.GITHUB_TOKEN }}
+
+      - name: Build and push Docker image
+        uses: docker/build-push-action@ad44023a93711e3deb337508980b4b5e9bcdc5dc
+        with:
+          context: .
+          file: ./Dockerfile
+          push: true
+          tags: ${{ env.REGISTRY }}/${{ env.IMAGE_NAME }}:${{ github.event.inputs.colabfold_version }}-cuda${{ matrix.cuda_version }}
+          platforms: linux/amd64 # ,linux/arm64
+          cache-from: type=gha
+          cache-to: type=gha,mode=max
+          build-args: |
+            CUDA_VERSION=${{ matrix.cuda_version }}
+            COLABFOLD_VERSION=${{ github.event.inputs.colabfold_version }}