diff --git a/.github/workflows/hypothesis.yml b/.github/workflows/hypothesis.yml
new file mode 100644
index 0000000000..cf5fa5ea25
--- /dev/null
+++ b/.github/workflows/hypothesis.yml
@@ -0,0 +1,28 @@
+name: Hypothesis tests
+
+on:
+  push:
+    branches: [latest]
+  pull_request:
+    branches: [latest]
+  schedule:
+    - cron: "0 0 * * *" # daily
+
+jobs:
+  test:
+    runs-on: ubuntu-latest
+    steps:
+      - uses: actions/checkout@v1
+
+      - name: Set up Python 3.7
+        uses: actions/setup-python@v1
+        with:
+          python-version: "3.7"
+
+      - name: Install dependencies
+        run: |
+          python -m pip install --upgrade pip
+          pip install tox
+
+      - name: Run Hypothesis tests
+        run: tox -e hypothesis,coverage
diff --git a/.github/workflows/khmer.yml b/.github/workflows/khmer.yml
index a895827dac..056e5ae1b1 100644
--- a/.github/workflows/khmer.yml
+++ b/.github/workflows/khmer.yml
@@ -22,20 +22,10 @@ jobs:
       - name: Install dependencies
         run: |
           python -m pip install --upgrade pip
-          python -m pip install -e .[test]
+          pip install tox
 
       - name: Run tests with latest released khmer
-        run: |
-          python -m pip install khmer
-          python -m pytest -k test_nodegraph --cov=. --cov-report=xml
-
-      - name: Run tests with khmer master tests
-        run: |
-          python -m pip install -U git+https://github.com/dib-lab/khmer.git#egg=khmer
-          python -m pytest -k test_nodegraph --cov=. --cov-report=xml
+        run: tox -e khmer,coverage
 
-      - name: Upload coverage to Codecov  
-        uses: codecov/codecov-action@v1
-        with:
-            file: ./coverage.xml
-            fail_ci_if_error: true
+      - name: Run tests with latest released khmer
+        run: tox -e khmer_master,coverage
diff --git a/tox.ini b/tox.ini
index d1c2807b26..7ab78f4187 100644
--- a/tox.ini
+++ b/tox.ini
@@ -200,9 +200,9 @@ source = src/sourmash/
 
 [gh-actions]
 python =
-  3.7: py37, khmer, khmer_master, coverage, codecov
+  3.7: py37, coverage, codecov
   3.8: py38, docs, package_description, fix_lint, coverage, codecov
-  3.9: py39, hypothesis, coverage, codecov
+  3.9: py39, coverage, codecov
 
 [flake8]
 max-complexity = 22