diff --git a/.github/dependabot.yml b/.github/dependabot.yml
index 8d8e23ce49..2ad9e7df51 100644
--- a/.github/dependabot.yml
+++ b/.github/dependabot.yml
@@ -12,6 +12,7 @@ updates:
   allow:
     - dependency-type: "direct"
   open-pull-requests-limit: 10
+  rebase-strategy: "disabled"  
 - package-ecosystem: "github-actions"
   directory: "/"
   schedule:
diff --git a/.readthedocs.yml b/.readthedocs.yml
index 0c7ae9f116..4a6db7b557 100644
--- a/.readthedocs.yml
+++ b/.readthedocs.yml
@@ -12,6 +12,10 @@ conda:
   environment: doc/environment.yml
 
 python:
+  # NOTE: doc/environment.yml specifies python=3.10, which is needed
+  # b/c of a pip problem; see
+  # https://github.com/sourmash-bio/sourmash/issues/2139
+  # this 'version' setting is effectively ignored, AFAICT. -- CTB 7/24/22
   version: 3.8
   install:
     - method: pip
diff --git a/Cargo.lock b/Cargo.lock
index 576e2ce0bb..e094cd4bbf 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -140,6 +140,12 @@ dependencies = [
  "rustc_version",
 ]
 
+[[package]]
+name = "cast"
+version = "0.3.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "37b2a672a2cb129a2e41c10b1224bb368f9f37a2b16b612598138befd7b37eb5"
+
 [[package]]
 name = "cc"
 version = "1.0.73"
@@ -197,9 +203,9 @@ dependencies = [
 
 [[package]]
 name = "counter"
-version = "0.5.5"
+version = "0.5.6"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "63b05d7acd00b53d97b7369c4062027ff55711db0c509f5b28d6d964a2f1ff87"
+checksum = "48388d8711a360319610960332b6a6f9fc2b5a63bba9fd10f1b7aa50677d956f"
 dependencies = [
  "num-traits",
 ]
@@ -215,12 +221,12 @@ dependencies = [
 
 [[package]]
 name = "criterion"
-version = "0.3.5"
+version = "0.3.6"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1604dafd25fba2fe2d5895a9da139f8dc9b319a5fe5354ca137cbbce4e178d10"
+checksum = "b01d6de93b2b6c65e17c634a26653a29d107b3c98c607c765bf38d041531cd8f"
 dependencies = [
  "atty",
- "cast",
+ "cast 0.3.0",
  "clap",
  "criterion-plot",
  "csv",
@@ -245,7 +251,7 @@ version = "0.4.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "d00996de9f2f7559f7f4dc286073197f83e92256a59ed395f9aac01fe717da57"
 dependencies = [
- "cast",
+ "cast 0.2.7",
  "itertools",
 ]
 
@@ -350,9 +356,9 @@ dependencies = [
 
 [[package]]
 name = "fixedbitset"
-version = "0.4.1"
+version = "0.4.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "279fb028e20b3c4c320317955b77c5e0c9701f05a1d309905d6fc702cdc5053e"
+checksum = "0ce7134b9999ecaf8bcd65542e436736ef32ddca1b3e06094cb6ec5755203b80"
 
 [[package]]
 name = "flate2"
@@ -510,9 +516,9 @@ dependencies = [
 
 [[package]]
 name = "memmap2"
-version = "0.5.4"
+version = "0.5.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d5172b50c23043ff43dd53e51392f36519d9b35a8f3a410d30ece5d1aedd58ae"
+checksum = "3a79b39c93a7a5a27eeaf9a23b5ff43f1b9e0ad6b1cdd441140ae53c35613fc7"
 dependencies = [
  "libc",
 ]
@@ -637,9 +643,9 @@ dependencies = [
 
 [[package]]
 name = "once_cell"
-version = "1.12.0"
+version = "1.13.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7709cef83f0c1f58f666e746a08b21e0085f7440fa6a29cc194d68aac97a4225"
+checksum = "18a6dbe30758c9f83eb00cbea4ac95966305f5a7772f3f42ebfc7fc7eddbd8e1"
 
 [[package]]
 name = "oorandom"
@@ -958,9 +964,9 @@ checksum = "a4a3381e03edd24287172047536f20cabde766e2cd3e65e6b00fb3af51c4f38d"
 
 [[package]]
 name = "serde"
-version = "1.0.137"
+version = "1.0.140"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "61ea8d54c77f8315140a05f4c7237403bf38b72704d031543aa1d16abbf517d1"
+checksum = "fc855a42c7967b7c369eb5860f7164ef1f6f81c20c7cc1141f2a604e18723b03"
 dependencies = [
  "serde_derive",
 ]
@@ -977,9 +983,9 @@ dependencies = [
 
 [[package]]
 name = "serde_derive"
-version = "1.0.137"
+version = "1.0.140"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1f26faba0c3959972377d3b2d306ee9f71faee9714294e41bb777f83f88578be"
+checksum = "6f2122636b9fe3b81f1cb25099fcf2d3f542cdb1d45940d56c713158884a05da"
 dependencies = [
  "proc-macro2",
  "quote",
@@ -988,9 +994,9 @@ dependencies = [
 
 [[package]]
 name = "serde_json"
-version = "1.0.81"
+version = "1.0.82"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9b7ce2b32a1aed03c558dc61a5cd328f15aff2dbc17daad8fb8af04d2100e15c"
+checksum = "82c2c1fdcd807d1098552c5b9a36e425e42e9fbd7c6a37a8425f390f781f7fa7"
 dependencies = [
  "itoa 1.0.1",
  "ryu",
diff --git a/doc/environment.yml b/doc/environment.yml
index f3840b2dce..129ee5700e 100644
--- a/doc/environment.yml
+++ b/doc/environment.yml
@@ -3,4 +3,5 @@ channels:
   - defaults
 dependencies:
   - rust
-  - python =3.8
+  - python=3.10
+  - pip
diff --git a/flake.lock b/flake.lock
index ad92340781..521c13d12e 100644
--- a/flake.lock
+++ b/flake.lock
@@ -64,11 +64,11 @@
     },
     "nixpkgs": {
       "locked": {
-        "lastModified": 1655481042,
-        "narHash": "sha256-XHbcywq2vIQ5CeH1OK3TN793jkiNAAZsSctS1PFgseo=",
+        "lastModified": 1658549974,
+        "narHash": "sha256-+D1gH6ecI14xDuObG07cd9XXhLDdLMRwOBDQmJcVluc=",
         "owner": "NixOS",
         "repo": "nixpkgs",
-        "rev": "103a4c0ae46afa9cf008c30744175315ca38e9f9",
+        "rev": "52dd719bbd13d9f0974e5c3c29c74aa249e5b091",
         "type": "github"
       },
       "original": {
@@ -150,11 +150,11 @@
         ]
       },
       "locked": {
-        "lastModified": 1655520266,
-        "narHash": "sha256-YEo20XNDKwFSMzg4wGDz/uxNmd/FleUPgVkFyWx3UWA=",
+        "lastModified": 1658544517,
+        "narHash": "sha256-ipu69vA0a6AcWZqnHLzeRhvnVZbURXALHLIsqQWtJe4=",
         "owner": "oxalica",
         "repo": "rust-overlay",
-        "rev": "da04f39d50ad2844e97a44015048c2510ca06c2f",
+        "rev": "4bd340885e39e0625fc6dda8a5a9d13c921ebb96",
         "type": "github"
       },
       "original": {
@@ -165,11 +165,11 @@
     },
     "utils": {
       "locked": {
-        "lastModified": 1653893745,
-        "narHash": "sha256-0jntwV3Z8//YwuOjzhV2sgJJPt+HY6KhU7VZUL0fKZQ=",
+        "lastModified": 1656928814,
+        "narHash": "sha256-RIFfgBuKz6Hp89yRr7+NR5tzIAbn52h8vT6vXkYjZoM=",
         "owner": "numtide",
         "repo": "flake-utils",
-        "rev": "1ed9fb1935d260de5fe1c2f7ee0ebaae17ed2fa1",
+        "rev": "7e2a3b3dfd9af950a856d66b0a7d01e3c18aa249",
         "type": "github"
       },
       "original": {
diff --git a/flake.nix b/flake.nix
index cfef19b8c4..db03a85b04 100644
--- a/flake.nix
+++ b/flake.nix
@@ -68,7 +68,7 @@
           sourmash = mach-nix-wrapper.buildPythonPackage {
             src = ./.;
             pname = "sourmash";
-            version = "4.4.0";
+            version = "4.4.2";
             requirements = ''
               screed>=1.0.5
               cffi>=1.14.0
@@ -80,11 +80,12 @@
               bitstring<4,>=3.1.9
             '';
             requirementsExtra = ''
-              setuptools
+              setuptools >= 61
               milksnake
               setuptools_scm[toml] >= 4, <6
+              wheel >= 0.29.0
             '';
-            SETUPTOOLS_SCM_PRETEND_VERSION = "4.4.0";
+            SETUPTOOLS_SCM_PRETEND_VERSION = "4.4.2";
             DYLD_LIBRARY_PATH = "${self.packages.${system}.lib}/lib";
             NO_BUILD = "1";
           };