diff --git a/setup.py b/setup.py
index a53e906d0cc..e95b8ee93ee 100644
--- a/setup.py
+++ b/setup.py
@@ -291,10 +291,7 @@ def run(self):
     'numpydoc',
     # Packages for pyqt5 are only available in
     # Python 3
-    'pyqt5<5.10;python_version>="3"',
-    # This is only needed for our wheels on Linux.
-    # See issue #3332
-    'pyopengl;platform_system=="Linux"'
+    'pyqt5<5.10;python_version>="3"'
 ]
 
 extras_require = {
diff --git a/spyder/app/start.py b/spyder/app/start.py
index ef3c88c05bc..bde5380354a 100644
--- a/spyder/app/start.py
+++ b/spyder/app/start.py
@@ -1,6 +1,7 @@
 # -*- coding: utf-8 -*-
 
 # Std imports
+import ctypes
 import os
 import os.path as osp
 import random
@@ -12,10 +13,10 @@
 # See issue 5324
 import zmq
 
-# This import is needed to fix errors with OpenGL when installed using pip
-# See issue 3332
+# Load GL library to prevent segmentation faults on some Linux systems
+# See issues 3226 and 3332
 try:
-    from OpenGL import GL
+    ctypes.CDLL("libGL.so.1", mode=ctypes.RTLD_GLOBAL)
 except:
     pass