diff --git a/cores/arduino/stm32/backup.h b/cores/arduino/stm32/backup.h
index 7940c35ce7..525153368c 100644
--- a/cores/arduino/stm32/backup.h
+++ b/cores/arduino/stm32/backup.h
@@ -125,7 +125,7 @@ static inline void setBackupRegister(uint32_t index, uint32_t value)
   LL_RTC_BKP_SetRegister(BKP, index, value);
 #elif defined(STM32G0xx)
   LL_RTC_BKP_SetRegister(TAMP, index, value);
-#elif defined(STM32G4xx)
+#elif defined(STM32G4xx) || defined(STM32L5xx)
   LL_RTC_BKP_SetRegister(RTC, index, value);
 #else
 #ifdef ENABLE_BACKUP_SUPPORT
@@ -143,7 +143,7 @@ static inline uint32_t getBackupRegister(uint32_t index)
   return LL_RTC_BKP_GetRegister(BKP, index);
 #elif defined(STM32G0xx)
   return LL_RTC_BKP_GetRegister(TAMP, index);
-#elif defined(STM32G4xx)
+#elif defined(STM32G4xx) || defined(STM32L5xx)
   return LL_RTC_BKP_GetRegister(RTC, index);
 #else
 #ifdef ENABLE_BACKUP_SUPPORT
diff --git a/cores/arduino/stm32/stm32_def.h b/cores/arduino/stm32/stm32_def.h
index 5df75353b4..f9de262101 100644
--- a/cores/arduino/stm32/stm32_def.h
+++ b/cores/arduino/stm32/stm32_def.h
@@ -46,6 +46,8 @@
   #include "stm32l1xx.h"
 #elif defined(STM32L4xx)
   #include "stm32l4xx.h"
+#elif defined(STM32L5xx)
+  #include "stm32l5xx.h"
 #elif defined(STM32MP1xx)
   #include "stm32mp1xx.h"
 #elif defined(STM32WBxx)
diff --git a/cores/arduino/stm32/timer.h b/cores/arduino/stm32/timer.h
index 9275c4820e..e536708635 100644
--- a/cores/arduino/stm32/timer.h
+++ b/cores/arduino/stm32/timer.h
@@ -37,7 +37,10 @@ extern "C" {
 #endif
 
 #if defined(TIM1_BASE) && !defined(TIM1_IRQn)
-#if defined(STM32F0xx) || defined(STM32G0xx)
+#if defined(STM32L5xx)
+#define TIM1_IRQn TIM1_UP_IRQn
+#define TIM1_IRQHandler TIM1_UP_IRQHandler
+#elif defined(STM32F0xx) || defined(STM32G0xx)
 #define TIM1_IRQn TIM1_BRK_UP_TRG_COM_IRQn
 #define TIM1_IRQHandler TIM1_BRK_UP_TRG_COM_IRQHandler
 #elif defined(STM32F1xx) ||defined(STM32G4xx)
@@ -63,19 +66,45 @@ extern "C" {
 #define TIM1_IRQHandler TIM1_UP_IRQHandler
 #endif
 #endif
+
+#if defined(STM32L5xx)
+#if defined(TIM3_BASE) && !defined(TIM3_IRQn)
+#define TIM3_IRQn TIM3_IRQn
+#define TIM3_IRQHandler TIM3_IRQHandler
+#endif
+#if defined(TIM4_BASE) && !defined(TIM4_IRQn)
+#define TIM4_IRQn TIM4_IRQn
+#define TIM4_IRQHandler TIM4_IRQHandler
+#endif
+#if defined(TIM5_BASE) && !defined(TIM5_IRQn)
+#define TIM5_IRQn TIM5_IRQn
+#define TIM5_IRQHandler TIM5_IRQHandler
+#endif
+#endif
+
 #if defined(TIM6_BASE) && !defined(TIM6_IRQn)
+#if defined(STM32L5xx)
+#define TIM6_IRQn TIM6_IRQn
+#define TIM6_IRQHandler TIM6_IRQHandler
+#else
 #if defined(DAC_BASE) || defined(DAC1_BASE)
 #if defined(STM32G0xx)
 #define TIM6_IRQn TIM6_DAC_LPTIM1_IRQn
 #define TIM6_IRQHandler TIM6_DAC_LPTIM1_IRQHandler
 #elif !defined(STM32F1xx) && !defined(STM32L1xx) && !defined(STM32MP1xx)
 #define TIM6_IRQn TIM6_DAC_IRQn
-#define TIM6_IRQHandler TIM6_DAC_IRQHandler
+#define TIM6_IRQHandler TIM2_DAC_IRQHandler
+#endif
+#else
 #endif
 #endif
 #endif
+
 #if defined(TIM7_BASE) && !defined(TIM7_IRQn)
-#if defined(STM32G0xx) && defined(LPTIM2_BASE)
+#if defined(STM32L5xx)
+#define TIM7_IRQn TIM7_IRQn
+#define TIM7_IRQHandler TIM7_IRQHandler
+#elif defined(STM32G0xx) && defined(LPTIM2_BASE)
 #define TIM7_IRQn TIM7_LPTIM2_IRQn
 #define TIM7_IRQHandler TIM7_LPTIM2_IRQHandler
 #elif defined(STM32G4xx)
@@ -89,11 +118,13 @@ extern "C" {
  || defined(STM32H7xx)
 #define TIM8_IRQn TIM8_UP_TIM13_IRQn
 #define TIM8_IRQHandler TIM8_UP_TIM13_IRQHandler
-#elif  defined(STM32F3xx) || defined(STM32G4xx) || defined(STM32L4xx) || defined(STM32MP1xx)
+#elif  defined(STM32F3xx) || defined(STM32G4xx) || defined(STM32L4xx)\
+ || defined(STM32L5xx) || defined(STM32MP1xx)
 #define TIM8_IRQn TIM8_UP_IRQn
 #define TIM8_IRQHandler TIM8_UP_IRQHandler
 #endif
 #endif
+
 #if defined(TIM9_BASE) && !defined(TIM9_IRQn)
 #if defined(STM32F1xx) || defined(STM32F2xx) ||defined(STM32F4xx) || defined(STM32F7xx)
 #define TIM9_IRQn TIM1_BRK_TIM9_IRQn
diff --git a/libraries/SrcWrapper/src/stm32/analog.cpp b/libraries/SrcWrapper/src/stm32/analog.cpp
index ea8d0998b1..852b99d8de 100644
--- a/libraries/SrcWrapper/src/stm32/analog.cpp
+++ b/libraries/SrcWrapper/src/stm32/analog.cpp
@@ -842,8 +842,8 @@ uint16_t adc_read_value(PinName pin, uint32_t resolution)
 #endif
 #if !defined(STM32F1xx) && !defined(STM32F2xx) && !defined(STM32F3xx) && \
     !defined(STM32F4xx) && !defined(STM32F7xx) && !defined(STM32G4xx) && \
-    !defined(STM32H7xx) && !defined(STM32L4xx) && !defined(STM32MP1xx) && \
-    !defined(STM32WBxx)
+    !defined(STM32H7xx) && !defined(STM32L4xx) && !defined(STM32L5xx) && \
+    !defined(STM32MP1xx) && !defined(STM32WBxx)
   AdcHandle.Init.LowPowerAutoPowerOff  = DISABLE;                       /* ADC automatically powers-off after a conversion and automatically wakes-up when a new conversion is triggered */
 #endif
 #ifdef ADC_CHANNELS_BANK_A
@@ -913,7 +913,7 @@ uint16_t adc_read_value(PinName pin, uint32_t resolution)
 
   AdcChannelConf.Channel      = channel;                          /* Specifies the channel to configure into ADC */
 
-#if defined(STM32L4xx) || defined(STM32WBxx)
+#if defined(STM32L4xx) || defined(STM32L5xx) || defined(STM32WBxx)
   if (!IS_ADC_CHANNEL(&AdcHandle, AdcChannelConf.Channel)) {
 #elif defined(STM32G4xx)
   if (!IS_ADC_CHANNEL(&AdcHandle, AdcChannelConf.Channel)) {
diff --git a/libraries/SrcWrapper/src/stm32/interrupt.cpp b/libraries/SrcWrapper/src/stm32/interrupt.cpp
index 5a3d01f6da..1c568330cd 100644
--- a/libraries/SrcWrapper/src/stm32/interrupt.cpp
+++ b/libraries/SrcWrapper/src/stm32/interrupt.cpp
@@ -71,7 +71,7 @@ static gpio_irq_conf_str gpio_irq_conf[NB_EXTI] = {
   {.irqnb = EXTI4_15_IRQn,  .callback = NULL}, //GPIO_PIN_13
   {.irqnb = EXTI4_15_IRQn,  .callback = NULL}, //GPIO_PIN_14
   {.irqnb = EXTI4_15_IRQn,  .callback = NULL}  //GPIO_PIN_15
-#elif defined (STM32MP1xx)
+#elif defined (STM32MP1xx) || defined (STM32L5xx)
   {.irqnb = EXTI0_IRQn,     .callback = NULL}, //GPIO_PIN_0
   {.irqnb = EXTI1_IRQn,     .callback = NULL}, //GPIO_PIN_1
   {.irqnb = EXTI2_IRQn,     .callback = NULL}, //GPIO_PIN_2
diff --git a/libraries/SrcWrapper/src/stm32/system_stm32yyxx.c b/libraries/SrcWrapper/src/stm32/system_stm32yyxx.c
index 89da3e7ae0..1725d9c251 100644
--- a/libraries/SrcWrapper/src/stm32/system_stm32yyxx.c
+++ b/libraries/SrcWrapper/src/stm32/system_stm32yyxx.c
@@ -36,6 +36,9 @@
 #ifdef STM32L4xx
   #include "system_stm32l4xx.c"
 #endif
+#ifdef STM32L5xx
+  #include "system_stm32l5xx.c"
+#endif
 #ifdef STM32MP1xx
   #include "system_stm32mp1xx.c"
 #endif