diff --git a/libraries/SrcWrapper/src/stm32/pinmap.c b/libraries/SrcWrapper/src/stm32/pinmap.c
index d97b234bfc..fe1ee83d18 100644
--- a/libraries/SrcWrapper/src/stm32/pinmap.c
+++ b/libraries/SrcWrapper/src/stm32/pinmap.c
@@ -98,6 +98,12 @@ void pin_function(PinName pin, int function)
   /* Enable GPIO clock */
   GPIO_TypeDef *gpio = set_GPIO_Port_Clock(port);
 
+#if defined (STM32L5xx)
+  /* validate the V DDIO2 supply for electrical and logical isolation purpose.*/
+  __HAL_RCC_PWR_CLK_ENABLE();
+  HAL_PWREx_EnableVddIO2();
+#endif /* STM32L5xx */
+
 #if defined(STM32MP1xx)
   PERIPH_LOCK(gpio);
 #endif