diff --git a/src/native/libs/System.Globalization.Native/CMakeLists.txt b/src/native/libs/System.Globalization.Native/CMakeLists.txt
index fabfedd61b84b..5e9ccb1e8991b 100644
--- a/src/native/libs/System.Globalization.Native/CMakeLists.txt
+++ b/src/native/libs/System.Globalization.Native/CMakeLists.txt
@@ -107,13 +107,6 @@ else()
 endif()
 
 if (CLR_CMAKE_TARGET_APPLE)
-    if(CLR_CMAKE_TARGET_IOS)
-        add_definitions(-DTARGET_IOS)
-    elseif(CLR_CMAKE_TARGET_TVOS)
-        add_definitions(-DTARGET_TVOS)
-    elseif(CLR_CMAKE_TARGET_MACCATALYST)
-        add_definitions(-DTARGET_MACCATALYST)
-    endif()
     set(NATIVEGLOBALIZATION_SOURCES_OBJC
         pal_locale.m
         pal_collation.m