[Pathway Discussion]: WP5424 - Is it possible to add reactions that are suspected to occur in the human but only shown to occur in animals/in vitro yet ?

[JuliaBatUM]

Discussion

Hi!
The project goal is to create a map containing oxylipins and their role in senescence.
Concerning the pathway WP5424, there is a branch called "isoprostanes/isoprostaglandins". However, isoprostanes are a much bigger family than represented there as I only included the reactions shown to occur in the human. When I include reactions found in vitro/rabbits/rats, the isoprostaglandin family extends to over 120 reactions. Isoprostaglandins are shown to play a role in senescence (and are all possibly missing in the reference model human1) and, therefore, it would be interesting for us to add them too. I would also give us the opportunity to mention new directions and the need for more research on that subject in an upcoming review paper.
Here is an overview of what I have found yet:

And here is a zoom of one of the isoprostaglandin precursors, docosahexaenoic acid:

During the last meeting (02/11/23), I think we discussed representing these reactions on PathVisio but by adding a comment saying that these reactions are not yet observed in humans.

What are your suggestions?

Kind regards,
Julia

Type of revision

• Major
• Minor
• Deletion