diff --git a/assets/js/base/utils/lazy-load-script.ts b/assets/js/base/utils/lazy-load-script.ts
index 9758ecfd7f6..2a282dbef71 100644
--- a/assets/js/base/utils/lazy-load-script.ts
+++ b/assets/js/base/utils/lazy-load-script.ts
@@ -20,6 +20,14 @@ interface AppendScriptAttributesParam {
 	src?: string;
 }
 
+declare global {
+	interface Window {
+		wc: {
+			wcBlocksRegistry: Record< string, unknown >;
+		};
+	}
+}
+
 /**
  * In WP, registered scripts are loaded into the page with an element like this:
  * `<script src='...' id='[SCRIPT_ID]'></script>`
@@ -27,6 +35,16 @@ interface AppendScriptAttributesParam {
  * Useful to know if a script has already been appended to the page.
  */
 const isScriptTagInDOM = ( scriptId: string, src = '' ): boolean => {
+	// If the store is using a plugin to concatenate scripts, we might have some
+	// cases where we don't detect whether a script has already been loaded.
+	// Because of that, we add an extra protection to the wc-blocks-registry-js
+	// script, to avoid ending up with two registries.
+	if ( scriptId === 'wc-blocks-registry-js' ) {
+		if ( typeof window?.wc?.wcBlocksRegistry === 'object' ) {
+			return true;
+		}
+	}
+
 	const srcParts = src.split( '?' );
 	if ( srcParts?.length > 1 ) {
 		src = srcParts[ 0 ];
diff --git a/src/BlockTypes/MiniCart.php b/src/BlockTypes/MiniCart.php
index 6d5e054cdc5..64f4b44bc00 100644
--- a/src/BlockTypes/MiniCart.php
+++ b/src/BlockTypes/MiniCart.php
@@ -103,7 +103,7 @@ protected function get_block_type_script( $key = null ) {
 		$script = [
 			'handle'       => 'wc-' . $this->block_name . '-block-frontend',
 			'path'         => $this->asset_api->get_block_asset_build_path( $this->block_name . '-frontend' ),
-			'dependencies' => [ 'wc-blocks-registry' ],
+			'dependencies' => [],
 		];
 		return $key ? $script[ $key ] : $script;
 	}
@@ -282,7 +282,7 @@ protected function append_script_and_deps_src( $script ) {
 				}
 			}
 		}
-		if ( ! $script->src || 'wc-blocks-registry' === $script->handle ) {
+		if ( ! $script->src ) {
 			return;
 		}