DESCRIPTION

Package: mirage
Type: Package
Encoding: UTF-8
Title: An R package for mixture model based rare variant analysis on genes.
Version: 0.1.0.0
Date: 2019-08-08
Authors@R: c(person("Shengtong","Han",role=c("aut"), email="shengtonghan@gmail.com"),
             person("Gao","Wang",role=c("aut", "cre"), email="wangow@gmail.com"),
             person("Xin","He",role="aut"))
Description: `mirage` is a new Bayesian statistical method for rare variant (RV) association testing that better accounts for heterogeneity of variant effects within a gene using 
    external annotation information. It models variants in a gene as a mixture of risk and non-risk variants, with a prior probability of being a risk variant determined by functional annotations of the variant such as
    conservation score and impact on protein structure. Since in general external annotations alone have limited accuracy in predicting functional effects, a simple filter based on such annotations (as commonly performed in 
    many RV association analysis) may result in both false positive and negatives. Instead, by incorporating such information as prior and using a hierarchical model to pool information across genes, `mirage` is able to better
    characterize the inclusion probability of rare variants for different functional categories, thus improving the power to detect an association.
URL: https://github.com/xinhe-lab/mirage
BugReports: https://github.com/xinhe-lab/mirage/issues
License: BSD_3_clause + file LICENSE
LazyData: true
Imports:
    progress,
    R6
Suggests:
    ggplot2,
    testthat,
    knitr,
    rmarkdown
VignetteBuilder: knitr
NeedsCompilation: no
RoxygenNote: 7.3.1