diff --git a/doc/source/whatsnew/v1.3.0.rst b/doc/source/whatsnew/v1.3.0.rst
index 31a34c0532811..a3638466d1265 100644
--- a/doc/source/whatsnew/v1.3.0.rst
+++ b/doc/source/whatsnew/v1.3.0.rst
@@ -603,6 +603,7 @@ Deprecations
 - Deprecated support for ``np.ma.mrecords.MaskedRecords`` in the :class:`DataFrame` constructor, pass ``{name: data[name] for name in data.dtype.names}`` instead (:issue:`40363`)
 - Deprecated the use of ``**kwargs`` in :class:`.ExcelWriter`; use the keyword argument ``engine_kwargs`` instead (:issue:`40430`)
 - Deprecated the ``level`` keyword for :class:`DataFrame` and :class:`Series` aggregations; use groupby instead (:issue:`39983`)
+- Deprecated :func:`merge` producing duplicated columns through the ``suffixes`` keyword  and already existing columns (:issue:`22818`)
 
 .. ---------------------------------------------------------------------------
 
diff --git a/pandas/core/reshape/merge.py b/pandas/core/reshape/merge.py
index 8cee0dd2abb88..5a13506a42011 100644
--- a/pandas/core/reshape/merge.py
+++ b/pandas/core/reshape/merge.py
@@ -2311,4 +2311,22 @@ def renamer(x, suffix):
     lrenamer = partial(renamer, suffix=lsuffix)
     rrenamer = partial(renamer, suffix=rsuffix)
 
-    return (left._transform_index(lrenamer), right._transform_index(rrenamer))
+    llabels = left._transform_index(lrenamer)
+    rlabels = right._transform_index(rrenamer)
+
+    dups = []
+    if not llabels.is_unique:
+        # Only warn when duplicates are caused because of suffixes, already duplicated
+        # columns in origin should not warn
+        dups = llabels[(llabels.duplicated()) & (~left.duplicated())].tolist()
+    if not rlabels.is_unique:
+        dups.extend(rlabels[(rlabels.duplicated()) & (~right.duplicated())].tolist())
+    if dups:
+        warnings.warn(
+            f"Passing 'suffixes' which cause duplicate columns {set(dups)} in the "
+            f"result is deprecated and will raise a MergeError in a future version.",
+            FutureWarning,
+            stacklevel=4,
+        )
+
+    return llabels, rlabels
diff --git a/pandas/tests/reshape/merge/test_join.py b/pandas/tests/reshape/merge/test_join.py
index fb161e38c7155..166aa3f5e3263 100644
--- a/pandas/tests/reshape/merge/test_join.py
+++ b/pandas/tests/reshape/merge/test_join.py
@@ -629,7 +629,8 @@ def test_join_dups(self):
         dta = x.merge(y, left_index=True, right_index=True).merge(
             z, left_index=True, right_index=True, how="outer"
         )
-        dta = dta.merge(w, left_index=True, right_index=True)
+        with tm.assert_produces_warning(FutureWarning, check_stacklevel=False):
+            dta = dta.merge(w, left_index=True, right_index=True)
         expected = concat([x, y, z, w], axis=1)
         expected.columns = ["x_x", "y_x", "x_y", "y_y", "x_x", "y_x", "x_y", "y_y"]
         tm.assert_frame_equal(dta, expected)
diff --git a/pandas/tests/reshape/merge/test_merge.py b/pandas/tests/reshape/merge/test_merge.py
index 9699a0dec4891..1495a34274a94 100644
--- a/pandas/tests/reshape/merge/test_merge.py
+++ b/pandas/tests/reshape/merge/test_merge.py
@@ -2409,3 +2409,40 @@ def test_merge_result_empty_index_and_on():
 
     result = merge(df2, df1, left_index=True, right_on=["b"])
     tm.assert_frame_equal(result, expected)
+
+
+def test_merge_suffixes_produce_dup_columns_warns():
+    # GH#22818
+    left = DataFrame({"a": [1, 2, 3], "b": 1, "b_x": 2})
+    right = DataFrame({"a": [1, 2, 3], "b": 2})
+    expected = DataFrame(
+        [[1, 1, 2, 2], [2, 1, 2, 2], [3, 1, 2, 2]], columns=["a", "b_x", "b_x", "b_y"]
+    )
+    with tm.assert_produces_warning(FutureWarning):
+        result = merge(left, right, on="a")
+    tm.assert_frame_equal(result, expected)
+
+    with tm.assert_produces_warning(FutureWarning):
+        merge(right, left, on="a", suffixes=("_y", "_x"))
+    tm.assert_frame_equal(result, expected)
+
+
+def test_merge_duplicate_columns_with_suffix_no_warning():
+    # GH#22818
+    # Do not raise warning when duplicates are caused by duplicates in origin
+    left = DataFrame([[1, 1, 1], [2, 2, 2]], columns=["a", "b", "b"])
+    right = DataFrame({"a": [1, 3], "b": 2})
+    result = merge(left, right, on="a")
+    expected = DataFrame([[1, 1, 1, 2]], columns=["a", "b_x", "b_x", "b_y"])
+    tm.assert_frame_equal(result, expected)
+
+
+def test_merge_duplicate_columns_with_suffix_causing_another_duplicate():
+    # GH#22818
+    # This should raise warning because suffixes cause another collision
+    left = DataFrame([[1, 1, 1, 1], [2, 2, 2, 2]], columns=["a", "b", "b", "b_x"])
+    right = DataFrame({"a": [1, 3], "b": 2})
+    with tm.assert_produces_warning(FutureWarning):
+        result = merge(left, right, on="a")
+    expected = DataFrame([[1, 1, 1, 1, 2]], columns=["a", "b_x", "b_x", "b_x", "b_y"])
+    tm.assert_frame_equal(result, expected)