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<html><head><meta http-equiv="content-type" content="text/html; charset=utf-8"/><meta name="viewport" content="width=device-width, initial-scale=0.8"/><title>6 Agents alkylants</title><link rel="stylesheet" type="text/css" href="scribble.css" title="default"/><link rel="stylesheet" type="text/css" href="manual-style.css" title="default"/><link rel="stylesheet" type="text/css" href="manual-racket.css" title="default"/><script type="text/javascript" src="scribble-common.js"></script><script type="text/javascript" src="manual-racket.js"></script><!--[if IE 6]><style type="text/css">.SIEHidden { overflow: hidden; }</style><![endif]--></head><body id="scribble-racket-lang-org"><div class="tocset"><div class="tocview"><div class="tocviewlist tocviewlisttopspace"><div class="tocviewtitle"><table cellspacing="0" cellpadding="0"><tr><td style="width: 1em;"><a href="javascript:void(0);" title="Expand/Collapse" class="tocviewtoggle" onclick="TocviewToggle(this,"tocview_0");">▼</a></td><td></td><td><a href="index.html" class="tocviewlink" data-pltdoc="x">Cardiovasculaire et Strategies anti-<wbr></wbr>infectieuses</a></td></tr></table></div><div class="tocviewsublisttop" style="display: block;" id="tocview_0"><table cellspacing="0" cellpadding="0"><tr><td align="right">1 </td><td><a href="Antifongiques.html" class="tocviewlink" data-pltdoc="x">Antifongiques</a></td></tr><tr><td align="right">2 </td><td><a href="Antihypertenseurs.html" class="tocviewlink" data-pltdoc="x">Antihypertenseurs</a></td></tr><tr><td align="right">3 </td><td><a href="Hypolipemiants.html" class="tocviewlink" data-pltdoc="x">Hypolipemiants</a></td></tr><tr><td align="right">4 </td><td><a href="antitum.html" class="tocviewlink" data-pltdoc="x">Antitumoraux</a></td></tr><tr><td align="right">5 </td><td><a href="ksein.html" class="tocviewlink" data-pltdoc="x">traitement hormonologique du cancer du sein</a></td></tr><tr><td align="right">6 </td><td><a href="" class="tocviewselflink" data-pltdoc="x">Agents alkylants</a></td></tr><tr><td align="right">7 </td><td><a href="Chimir_sistance_au_Cancer.html" class="tocviewlink" data-pltdoc="x">Chimirésistance au Cancer</a></td></tr></table></div></div><div class="tocviewlist"><table cellspacing="0" cellpadding="0"><tr><td style="width: 1em;"><a href="javascript:void(0);" title="Expand/Collapse" class="tocviewtoggle" onclick="TocviewToggle(this,"tocview_1");">►</a></td><td>6 </td><td><a href="" class="tocviewselflink" data-pltdoc="x">Agents alkylants</a></td></tr></table><div class="tocviewsublistbottom" style="display: none;" id="tocview_1"><table cellspacing="0" cellpadding="0"><tr><td align="right">6.1 </td><td><a href="#%28part._moutardes%29" class="tocviewlink" data-pltdoc="x">Moutardes Azotées</a></td></tr></table></div></div></div><div class="tocsub"><div class="tocsubtitle">On this page:</div><table class="tocsublist" cellspacing="0"><tr><td><span class="tocsublinknumber">6.1<tt> </tt></span><a href="#%28part._moutardes%29" class="tocsubseclink" data-pltdoc="x">Moutardes Azotées</a></td></tr></table></div></div><div class="maincolumn"><div class="main"><div class="versionbox"><span class="version">7.9</span></div><div class="navsettop"><span class="navleft"><div class="nosearchform"></div> </span><span class="navright"> <a href="ksein.html" title="backward to "5 traitement hormonologique du cancer du sein"" data-pltdoc="x">← prev</a> <a href="index.html" title="up to "Cardiovasculaire et Strategies anti-infectieuses"" data-pltdoc="x">up</a> <a href="Chimir_sistance_au_Cancer.html" title="forward to "7 Chimirésistance au Cancer"" data-pltdoc="x">next →</a></span> </div><h3>6<tt> </tt><a name="(part._.Agents_alkylants)"></a>Agents alkylants</h3><h4>6.1<tt> </tt><a name="(part._moutardes)"></a>Moutardes Azotées</h4><p><div class="SIntrapara"><img src="moutarde.png" alt="" width="406" height="287"/>
</div><div class="SIntrapara"><span style="font-weight: bold">Mécanisme d’action</span>
L’ion <span class="emph">aziridinium</span> obtenu par élimination du Cl<span style="vertical-align: super; font-size: 80%">-</span> se fixe sur les résidus guanine par des liaisons covalentes stables. Il fait des pontages <span style="font-weight: bold">inter-brins</span> qui entraînent l’apoptose de la cellule.</div></p><div class="navsetbottom"><span class="navleft"><div class="nosearchform"></div> </span><span class="navright"> <a href="ksein.html" title="backward to "5 traitement hormonologique du cancer du sein"" data-pltdoc="x">← prev</a> <a href="index.html" title="up to "Cardiovasculaire et Strategies anti-infectieuses"" data-pltdoc="x">up</a> <a href="Chimir_sistance_au_Cancer.html" title="forward to "7 Chimirésistance au Cancer"" data-pltdoc="x">next →</a></span> </div></div></div><div id="contextindicator"> </div></body></html>