IISc Computational Oncology Project

Angiogenesis Simulation Model

This model includes five different simulations:

1. Without Any Treatment/Original: Baseline simulation of angiogenesis without any interventions.
2. Stalk Cell Inhibiting Drug: Simulation with a drug that inhibits the growth of stalk cells.
3. T-Cell Integration: Simulation incorporating the effects of immune cells, specifically T-cells, on angiogenesis.
4. Immune Integraton & Drug Therapy: Combined simulation of immune cell effects and stalk cell inhibiting drug.
5. Increasing VEGF Threshold: Simulation with an increased VEGF threshold to prevent the conversion of endothelial cells to tip cells.

Installation

To run this model, you need to install the libMesh library. Follow these steps to install libMesh:

1. Download libMesh:

   git clone https://github.com/libMesh/libmesh.git
   cd libmesh
   
   ./configure
   make
   make install
   

Running Simulation

Copy the Makefile: Copy the Makefile from libmesh/introduction/ex4 and paste it into your working directory:

make run