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ApPredict for use with Chaste 2018.1
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@mirams mirams released this 02 Jan 16:00
v2018.1
c46b1fa

ApPredict 2018.1

This version of ApPredict is compatible with Chaste 2018.1 which can be downloaded here.

Release Notes

CiPA-related Features

  • The FDA's version of the CiPA O'Hara-Rudy Dynamic Model (CipaORdv1) can now be used with the argument --model 8, and we have also made it available for anyone else to use via the CellML repository.

  • The FDA's qNet metric can now be calculated and output. This happens automatically when --model 8 --pacing-freq 0.5 is used.

Specifying test concentrations by file (for PKPD runs)

  • If you want to run at concentrations in a file instead of specifying at command line, you can do --pkpd-file <relative or absolute filepath>.
  • To evaluate APD90s throughout a set of up to N profiles of free concentration through time please provide a file with this data format for each row:
    Time(any units)<tab>Conc_trace_1(uM)<tab>Conc_trace_2(uM)<tab>...Conc_trace_N(uM)

Lookup tables

  • Improvements have been made to the Lookup Tables (used for uncertainty quantification) and now the lowest dimensional lookup table that is available for the ion channels of interest will be downloaded and used automatically. If you are using this feature please let me know as it may change a bit in future...
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