simultaneous nebulization and intravenous drip administration

[Mannny-PK]

How do I define the absorption and central chambers when a patient is administered by multiple routes, such as simultaneous nebulization and intravenous drip administration?

#Primary
Ka, 0.1, 0.9
Ke, 0.001, 0.1
V, 30, 120
Tlag1, 0, 4

#Cov

WT

AFRICA

AGE

GENDER

HEIGHT

#Lag
TLAG(1) = Tlag1

#Out
Y(1) = X(2)/V

#Err
G=5
0.02, 0.05, -0.0002, 0

[mhovd]

You can specify where a bolus dose will be administered with the #BOL block. Default behavior is for input 1 to go to compartment 1, etc. Per the documentation for legacy Pmetrics, this can be specified with

#BOL
NBCOMP(1) = 2

With the R6 framework, it is similarly defined with bol, e.g.

mod <- PM_model$new(list(
  bol = list("NBCOMP(1) = 2")
))

The above code is for bolus doses (DUR = 0), and will be delivered instantly. If you have infusions (DUR > 0), you can simply use RATEIV(n) where n is the input number for the administration pathway in your differential equations.

[Mannny-PK]

Many thanks for your help.