Matteopaluh · Matteopaluh · Apr 8, 2022 · Apr 6, 2022
diff --git a/KEGG_MODULES/M00910_Phenylalanine_biosynthesis.txt b/KEGG_MODULES/M00910_Phenylalanine_biosynthesis.txt
@@ -0,0 +1,29 @@
+ENTRY       M00910            Pathway   Module
+NAME        Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine
+DEFINITION  K01850 K15849 K05359
+ORTHOLOGY   K01850  chorismate mutase [EC:5.4.99.5] [RN:R01715]
+            K15849  bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.78 2.6.1.79] [RN:R01731 R07276]
+            K05359  arogenate dehydratase [EC:4.2.1.91 4.2.1.51] [RN:R00691]
+CLASS       Pathway modules; Amino acid metabolism; Aromatic amino acid metabolism
+PATHWAY     map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
+            map01230  Biosynthesis of amino acids
+            map01100  Metabolic pathways
+            map01110  Biosynthesis of secondary metabolites
+REACTION    R01715  C00251 -> C00254
+            R01731,R07276  C00254 -> C00826
+            R00691  C00826 -> C00079
+COMPOUND    C00251  Chorismate
+            C00254  Prephenate
+            C00826  L-Arogenate
+            C00079  L-Phenylalanine
+REFERENCE   PMID:22554242
+  AUTHORS   Maeda H, Dudareva N
+  TITLE     The shikimate pathway and aromatic amino Acid biosynthesis in plants.
+  JOURNAL   Annu Rev Plant Biol 63:73-105 (2012)
+            DOI:10.1146/annurev-arplant-042811-105439
+REFERENCE   PMID:22303258
+  AUTHORS   Tzin V, Galili G
+  TITLE     The Biosynthetic Pathways for Shikimate and Aromatic Amino Acids in Arabidopsis thaliana.
+  JOURNAL   Arabidopsis Book 8:e0132 (2010)
+            DOI:10.1199/tab.0132
+///
diff --git a/KEGG_MODULES/M00911_Riboflavin_biosynthesis_fungi.txt b/KEGG_MODULES/M00911_Riboflavin_biosynthesis_fungi.txt
@@ -0,0 +1,43 @@
+ENTRY       M00911            Pathway   Module
+NAME        Riboflavin biosynthesis, fungi, GTP => riboflavin/FMN/FAD
+DEFINITION  K01497 K14654 K14655 --
+            K02858
+            K00794 K00793 K00861 K00953
+ORTHOLOGY   K01497  GTP cyclohydrolase II [EC:3.5.4.25] [RN:R00425]
+            K14654  2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [EC:1.1.1.302] [RN:R09375 R09376]
+            K14655  2,5-diamino-6-(5-phospho-D-ribitylamino)-pyrimidin-4(3H)-one deaminase [RN:R09377]
+            K02858  3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12] [RN:R07281]
+            K00794  6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78] [RN:R04457]
+            K00793  riboflavin synthase [EC:2.5.1.9] [RN:R00066]
+            K00861  riboflavin kinase [EC:2.7.1.26] [RN:R00549]
+            K00953  FAD synthetase [EC:2.7.7.2] [RN:R00161]
+CLASS       Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
+PATHWAY     map00740  Riboflavin metabolism
+            map01240  Biosynthesis of cofactors
+            map01100  Metabolic pathways
+REACTION    R00425  C00044 -> C01304
+            R09375,R09376  C01304 -> C18910
+            R09377  C18910 -> C04454
+            R07280  C04454 -> C04732
+            R07281  C00199 -> C15556
+            R04457  C04732 + C15556 -> C04332
+            R00066  C04332 -> C00255
+            R00549  C00255 -> C00061
+            R00161  C00061 -> C00016
+COMPOUND    C00044  GTP
+            C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
+            C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
+            C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
+            C04732  5-Amino-6-(1-D-ribitylamino)uracil
+            C00199  D-Ribulose 5-phosphate
+            C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
+            C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
+            C00255  Riboflavin
+            C00061  FMN
+            C00016  FAD
+REFERENCE   PMID:10940330
+  AUTHORS   Bacher A, Eberhardt S, Fischer M, Kis K, Richter G
+  TITLE     Biosynthesis of vitamin b2 (riboflavin).
+  JOURNAL   Annu Rev Nutr 20:153-67 (2000)
+            DOI:10.1146/annurev.nutr.20.1.153
+///
diff --git a/KEGG_MODULES/M00912_NAD_biosynthesis.txt b/KEGG_MODULES/M00912_NAD_biosynthesis.txt
@@ -0,0 +1,53 @@
+ENTRY       M00912            Pathway   Module
+NAME        NAD biosynthesis, tryptophan => quinolinate => NAD
+DEFINITION  (K00453,K00463) (K01432,K14263,K07130) K00486 K01556 K00452 K00767 (K00969,K06210) (K01916,K01950)
+ORTHOLOGY   K00453  tryptophan 2,3-dioxygenase [EC:1.13.11.11] [RN:R00678]
+            K00463  indoleamine 2,3-dioxygenase [EC:1.13.11.52] [RN:R00678]
+            K01432,K14263,K07130  kynurenine formamidase [EC:3.5.1.9] [RN:R01959]
+            K00486  kynurenine 3-monooxygenase [EC:1.14.13.9] [RN:R01960]
+            K01556  kynureninase [EC:3.7.1.3] [RN:R02668]
+            K00452  3-hydroxyanthranilate 3,4-dioxygenase [EC:1.13.11.6] [RN:R02665]
+            K00767  nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] [RN:R03348]
+            K00969,K06210  nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] [RN:R03005]
+            K01916  NAD+ synthase [EC:6.3.1.5] [RN:R00189]
+            K01950  NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1] [RN:R00257]
+CLASS       Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
+PATHWAY     map00380  Tryptophan metabolism
+            map00760  Nicotinate and nicotinamide metabolism
+            map01240  Biosynthesis of cofactors
+            map01100  Metabolic pathways
+REACTION    R00678  C00078 -> C02700
+            R01959  C02700 -> C00328
+            R01960  C00328 -> C03227
+            R02668  C03227 -> C00632
+            R02665  C00632 -> C04409
+            R04293  C04409 -> C03722
+            R03348  C03722 -> C01185
+            R03005  C01185 -> C00857
+            R00189,R00257  C00857 -> C00003
+COMPOUND    C00078  L-Tryptophan
+            C02700  L-Formylkynurenine
+            C00328  L-Kynurenine
+            C03227  3-Hydroxy-L-kynurenine
+            C00632  3-Hydroxyanthranilate
+            C04409  2-Amino-3-carboxymuconate semialdehyde
+            C03722  Quinolinate
+            C01185  Nicotinate D-ribonucleotide
+            C00857  Deamino-NAD+
+            C00003  NAD+
+REFERENCE   PMID:12062417
+  AUTHORS   Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ
+  TITLE     Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae.
+  JOURNAL   FEBS Lett 517:97-102 (2002)
+            DOI:10.1016/s0014-5793(02)02585-1
+REFERENCE   PMID:18205391
+  AUTHORS   Wogulis M, Chew ER, Donohoue PD, Wilson DK
+  TITLE     Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence.
+  JOURNAL   Biochemistry 47:1608-21 (2008)
+            DOI:10.1021/bi701172v
+REFERENCE   PMID:14700627
+  AUTHORS   Kurnasov O, Goral V, Colabroy K, Gerdes S, Anantha S, Osterman A, Begley TP
+  TITLE     NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.
+  JOURNAL   Chem Biol 10:1195-204 (2003)
+            DOI:10.1016/j.chembiol.2003.11.011
+///
diff --git a/KEGG_MODULES/M00913_Pantothenate_biosynthesis.txt b/KEGG_MODULES/M00913_Pantothenate_biosynthesis.txt
@@ -0,0 +1,36 @@
+ENTRY       M00913            Pathway   Module
+NAME        Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate
+DEFINITION  K00606 K00077
+            K13367 K00128
+            K01918
+ORTHOLOGY   K00606  3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] [RN:R01226]
+            K00077  2-dehydropantoate 2-reductase [EC:1.1.1.169] [RN:R02472]
+            K13367  polyamine oxidase [EC:1.5.3.17] [RN:R09076]
+            K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] [RN:R00904]
+            K01918  pantoate--beta-alanine ligase [EC:6.3.2.1] [RN:R02473]
+CLASS       Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
+PATHWAY     map00770  Pantothenate and CoA biosynthesis
+            map01240  Biosynthesis of cofactors
+            map01100  Metabolic pathways
+REACTION    R01226  C00141 -> C00966
+            R02472  C00966 -> C00522
+            R09076  C00750 -> C05665
+            R00904  C05665 -> C00099
+            R02473  C00522 + C00099 -> C00864
+COMPOUND    C00141  3-Methyl-2-oxobutanoic acid
+            C00966  2-Dehydropantoate
+            C00522  (R)-Pantoate
+            C00750  Spermine
+            C05665  3-Aminopropanal
+            C00099  beta-Alanine
+            C00864  Pantothenate
+REFERENCE   PMID:11154694
+  AUTHORS   White WH, Gunyuzlu PL, Toyn JH
+  TITLE     Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine.
+  JOURNAL   J Biol Chem 276:10794-800 (2001)
+            DOI:10.1074/jbc.M009804200
+REFERENCE   PMID:12586697
+  AUTHORS   White WH, Skatrud PL, Xue Z, Toyn JH
+  TITLE     Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae.
+  JOURNAL   Genetics 163:69-77 (2003)
+///
diff --git a/KEGG_MODULES/M00914_Coenzyme_A_biosynthesis_archaea.txt b/KEGG_MODULES/M00914_Coenzyme_A_biosynthesis_archaea.txt
@@ -0,0 +1,37 @@
+ENTRY       M00914            Pathway   Module
+NAME        Coenzyme A biosynthesis, archaea, 2-oxoisovalerate => 4-phosphopantoate => CoA
+DEFINITION  K00606 K00077 K06982 K09722 K13038 K02201 K09735
+ORTHOLOGY   K00606  3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] [RN:R01226]
+            K00077  2-dehydropantoate 2-reductase [EC:1.1.1.169] [RN:R02472]
+            K06982  pantoate kinase [EC:2.7.1.169] [RN:R09378]
+            K09722  4-phosphopantoate---beta-alanine ligase [EC:6.3.2.36] [RN:R09379]
+            K13038  phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5] [RN:R04231 R03269]
+            K02201  pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] [RN:R03035]
+            K09735  GTP-dependent dephospho-CoA kinase [EC:2.7.1.-] [RN:R12608]
+CLASS       Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
+PATHWAY     map00770  Pantothenate and CoA biosynthesis
+            map01240  Biosynthesis of cofactors
+            map01100  Metabolic pathways
+REACTION    R01226  C00141 -> C00966
+            R02472  C00966 -> C00522
+            R09378  C00522 -> C18911
+            R09379  C18911 -> C03492
+            R04231  C03492 -> C04352
+            R03269  C04352 -> C01134
+            R03035  C01134 -> C00882
+            R12608  C00882 -> C00010
+COMPOUND    C00141  3-Methyl-2-oxobutanoic acid
+            C00966  2-Dehydropantoate
+            C00522  (R)-Pantoate
+            C18911  (R)-4-Phosphopantoate
+            C03492  D-4'-Phosphopantothenate
+            C04352  (R)-4'-Phosphopantothenoyl-L-cysteine
+            C01134  Pantetheine 4'-phosphate
+            C00882  Dephospho-CoA
+            C00010  CoA
+REFERENCE   PMID:31337720
+  AUTHORS   Shimosaka T, Makarova KS, Koonin EV, Atomi H
+  TITLE     Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea.
+  JOURNAL   mBio 10:e01146-19 (2019)
+            DOI:10.1128/mBio.01146-19
+///
diff --git a/KEGG_MODULES/M00915_Caffeine_degradation.txt b/KEGG_MODULES/M00915_Caffeine_degradation.txt
@@ -0,0 +1,31 @@
+ENTRY       M00915            Pathway   Module
+NAME        Caffeine degradation, caffeine => xanthine
+DEFINITION  K21722 K21723 K21724
+ORTHOLOGY   K21722  ndmA; methylxanthine N1-demethylase [EC:1.14.13.178] [RN:R07957 R07958 R07955 R07956]
+            K21723  ndmB; methylxanthine N3-demethylase [EC:1.14.13.179] [RN:R07954 R07939 R07961 R07962]
+            K21724  ndmC; 7-methylxanthine demethylase [EC:1.14.13.128] [RN:R07965 R07966]
+CLASS       Pathway modules; Xenobiotics biodegradation; Aromatics degradation
+PATHWAY     map00232  Caffeine metabolism
+            map01100  Metabolic pathways
+            map01120  Microbial metabolism in diverse environments
+REACTION    R07954,R07939  C07481 -> C13747
+            R07957,R07958  C13747 -> C16353
+            R07955,R07956  C07481 -> C07480
+            R07961,R07962  C07480 -> C16353
+            R07965,R07966  C16353 -> C00385
+COMPOUND    C07481  Caffeine
+            C13747  1,7-Dimethylxanthine
+            C16353  7-Methylxanthine
+            C07480  Theobromine
+            C00385  Xanthine
+REFERENCE   PMID:22328667
+  AUTHORS   Summers RM, Louie TM, Yu CL, Gakhar L, Louie KC, Subramanian M
+  TITLE     Novel, highly specific N-demethylases enable bacteria to live on caffeine and related purine alkaloids.
+  JOURNAL   J Bacteriol 194:2041-9 (2012)
+            DOI:10.1128/JB.06637-11
+REFERENCE   PMID:19447909
+  AUTHORS   Yu CL, Louie TM, Summers R, Kale Y, Gopishetty S, Subramanian M
+  TITLE     Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.
+  JOURNAL   J Bacteriol 191:4624-32 (2009)
+            DOI:10.1128/JB.00409-09
+///
diff --git a/KEGG_MODULES/M00916_Pyridoxal-P_biosynthesis.txt b/KEGG_MODULES/M00916_Pyridoxal-P_biosynthesis.txt
@@ -0,0 +1,30 @@
+ENTRY       M00916            Pathway   Module
+NAME        Pyridoxal-P biosynthesis, R5P + glyceraldehyde-3P + glutamine => pyridoxal-P
+DEFINITION  (K06215+K08681)
+ORTHOLOGY   K06215  pdxS; pyridoxal 5'-phosphate synthase pdxS subunit [EC:4.3.3.6] [RN:R10089]
+            K08681  pdxT; pyridoxal 5'-phosphate synthase pdxT subunit [EC:4.3.3.6] [RN:R10089]
+CLASS       Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
+PATHWAY     map00750  Vitamin B6 metabolism
+            map01240  Biosynthesis of cofactors
+            map01100  Metabolic pathways
+REACTION    R10089  C00117 + C00118 + C00064 -> C00018
+COMPOUND    C00117  D-Ribose 5-phosphate
+            C00118  D-Glyceraldehyde 3-phosphate
+            C00064  L-Glutamine
+            C00018  Pyridoxal phosphate
+REFERENCE   PMID:17822383
+  AUTHORS   Fitzpatrick TB, Amrhein N, Kappes B, Macheroux P, Tews I, Raschle T
+  TITLE     Two independent routes of de novo vitamin B6 biosynthesis: not that different after all.
+  JOURNAL   Biochem J 407:1-13 (2007)
+            DOI:10.1042/BJ20070765
+REFERENCE   PMID:16030023
+  AUTHORS   Raschle T, Amrhein N, Fitzpatrick TB
+  TITLE     On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis.
+  JOURNAL   J Biol Chem 280:32291-300 (2005)
+            DOI:10.1074/jbc.M501356200
+REFERENCE   PMID:16157873
+  AUTHORS   Tambasco-Studart M, Titiz O, Raschle T, Forster G, Amrhein N, Fitzpatrick TB.
+  TITLE     Vitamin B6 biosynthesis in higher plants.
+  JOURNAL   Proc Natl Acad Sci U S A 102:13687-92 (2005)
+            DOI:10.1073/pnas.0506228102
+///
diff --git a/KEGG_MODULES/M00917_Phytosterol_biosynthesis_squalene_2.txt b/KEGG_MODULES/M00917_Phytosterol_biosynthesis_squalene_2.txt
@@ -0,0 +1,72 @@
+ENTRY       M00917            Pathway   Module
+NAME        Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
+DEFINITION  K01853 K00559 K14423 K23558 -- K08246 K05917 K00222 K01824 K08242
+            K14424 K00227 K00213 K09828
+ORTHOLOGY   K01853  cycloartenol synthase [EC:5.4.99.8] [RN:R03200]
+            K00559  sterol 24-C-methyltransferase [EC:2.1.1.41] [RN:R07481]
+            K14423  plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase [EC:1.14.18.10] [RN:R12377]
+            K23558  plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase [EC:1.1.1.418] [RN:R12371 R12375 R12376]
+            K08246  cycloeucalenol cycloisomerase [EC:5.5.1.9] [RN:R03775]
+            K05917  sterol 14alpha-demethylase [EC:1.14.14.154] [RN:R05731]
+            K00222  Delta14-sterol reductase [EC:1.3.1.70] [RN:R07483]
+            K01824  cholestenol Delta-isomerase [EC:5.3.3.5] [RN:R07484]
+            K08242  24-methylenesterol C-methyltransferase [EC:2.1.1.143] [RN:R05776]
+            K14424  plant 4alpha-monomethylsterol monooxygenase [EC:1.14.18.11] [RN:R12378 R12379]
+            K00227  Delta7-sterol 5-desaturase [EC:1.14.19.20] [RN:R07491 R07486]
+            K00213  7-dehydrocholesterol reductase [EC:1.3.1.21] [RN:R07492 R07487]
+            K09828  Delta24-sterol reductase [EC:1.3.1.72 1.3.1.-] [RN:R07493 R07488]
+CLASS       Pathway modules; Lipid metabolism; Sterol biosynthesis
+PATHWAY     map00100  Steroid biosynthesis
+            map01100  Metabolic pathways
+            map01110  Biosynthesis of secondary metabolites
+REACTION    R03200  C01054 -> C01902
+            R07481  C01902 -> C08830
+            R12377  C08830 -> C22116
+            R12371  C22116 -> C22121
+            R12399  C22121 -> C02141
+            R03775  C02141 -> C01943
+            R05731  C01943 -> C11508
+            R07483  C11508 -> C15776
+            R07484  C15776 -> C11522
+            R05776  C11522 -> C11523
+            R12379  C11523 -> C22120
+            R12376  C22120 -> C22123
+            R12401  C22123 -> C15782
+            R07486  C15782 -> C15783
+            R07487  C15783 -> C08821
+            R07488  C08821 -> C01753
+            R12378  C11522 -> C22119
+            R12375  C22119 -> C22122
+            R12400  C22122 -> C15777
+            R07491  C15777 -> C15780
+            R07492  C15780 -> C15781
+            R07493  C15781 -> C01789
+COMPOUND    C01054  (S)-2,3-Epoxysqualene
+            C01902  Cycloartenol
+            C08830  24-Methylidenecycloartanol
+            C22116  3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylate
+            C22121  Cycloeucalenone
+            C02141  Cycloeucalenol
+            C01943  Obtusifoliol
+            C11508  4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
+            C15776  4alpha-Methylfecosterol
+            C11522  24-Methylenelophenol
+            C11523  24-Ethylidenelophenol
+            C22120  4alpha-Carboxy-stigmasta-7,24(24(1))-dien-3beta-ol
+            C22123  Avenastenone
+            C15782  Delta7-Avenasterol
+            C15783  5-Dehydroavenasterol
+            C08821  Isofucosterol
+            C01753  beta-Sitosterol
+            C22119  3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate
+            C22122  Episterone
+            C15777  Episterol
+            C15780  5-Dehydroepisterol
+            C15781  24-Methylenecholesterol
+            C01789  Campesterol
+REFERENCE   PMID:28005066
+  AUTHORS   Sonawane PD, Pollier J, Panda S, Szymanski J, Massalha H, Yona M, Unger T, Malitsky S, Arendt P, Pauwels L, Almekias-Siegl E, Rogachev I, Meir S, Cardenas PD, Masri A, Petrikov M, Schaller H, Schaffer AA, Kamble A, Giri AP, Goossens A, Aharoni A
+  TITLE     Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism.
+  JOURNAL   Nat Plants 3:16205 (2016)
+            DOI:10.1038/nplants.2016.205
+///
diff --git a/KEGG_MODULES/M00918_Aerobactin_biosynthesis.txt b/KEGG_MODULES/M00918_Aerobactin_biosynthesis.txt
@@ -0,0 +1,26 @@
+ENTRY       M00918            Pathway   Module
+NAME        Aerobactin biosynthesis, lysine => aerobactin
+DEFINITION  K03897 K03896 K03894 K03895
+ORTHOLOGY   K03897  iucD; lysine N6-hydroxylase [EC:1.14.13.59] [RN:R00448]
+            K03896  iucB; acetyl CoA:N6-hydroxylysine acetyl transferase [EC:2.3.1.102] [RN:R03168]
+            K03894  iucA; N2-citryl-N6-acetyl-N6-hydroxylysine synthase [EC:6.3.2.38] [RN:R10090]
+            K03895  iucC; aerobactin synthase [EC:6.3.2.39] [RN:R10091]
+CLASS       Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
+PATHWAY     map00997  Biosynthesis of various other secondary metabolites
+            map01100  Metabolic pathways
+            map01110  Biosynthesis of secondary metabolites
+REACTION    R00448  C00047 -> C01028
+            R03168  C01028 -> C03955
+            R10090  C03955 -> C20333
+            R10091  C20333 -> C05554
+COMPOUND    C00047  L-Lysine
+            C01028  N6-Hydroxy-L-lysine
+            C03955  N6-Acetyl-N6-hydroxy-L-lysine
+            C20333  N2-Citryl-N6-acetyl-N6-hydroxy-L-lysine
+            C05554  Aerobactin
+REFERENCE   PMID:1393837
+  AUTHORS   Neilands JB
+  TITLE     Mechanism and regulation of synthesis of aerobactin in Escherichia coli K12 (pColV-K30).
+  JOURNAL   Can J Microbiol 38:728-33 (1992)
+            DOI:10.1139/m92-119
+///