cao2017

h5ad file with data for 36k C. elegans cells from two sci-rna-seq experiments published in Cao et al, Science 2017 (https://doi.org/10.1126/science.aam8940)

Breakdown of cells per experiment:

L2_experiment_1    35480
L2_experiment_2      507

Head of cell annotation as example:

              barcode       experiment                        cell_type
0  A01_A02_AACTACCGAC  L2_experiment_1  hyp_4_to_7_bin_3_around_L2_molt
1  A01_A02_AACTACGGCT  L2_experiment_1                              ASI
2  A01_A02_AACTATTATA  L2_experiment_1                           mu_sph
3  A01_A02_AAGACGGCCA  L2_experiment_1                         Germline
4  A01_A02_AAGTTGCCAT  L2_experiment_1                         Germline

Gene annotations include WormBase short gene descriptions, for example:

               gene_id	gene_name	gene_description
0	WBGene00000001	aap-1           Exhibits protein kinase binding activity. Involved in dauer larval development; determination of adult lifespan; and insulin receptor signaling pathway. Localizes to the phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in several diseases, including astroblastoma; carcinoma (multiple); endometrial cancer (multiple); primary immunodeficiency disease (multiple); and type 2 diabetes mellitus. Is expressed in intestine and neurons. Orthologous to several human genes including PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3).
1	WBGene00000002	aat-1		Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Localizes to the amino acid transport complex. Is expressed in several structures, including excretory system; gonadal sheath cell; nervous system; pharynx; and rectal gland cell. Orthologous to several human genes including SLC7A8 (solute carrier family 7 member 8).
2	WBGene00000003	aat-2		Predicted to have L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in lysinuric protein intolerance. Orthologous to several human genes including SLC7A7 (solute carrier family 7 member 7).
3	WBGene00000004	aat-3		Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Localizes to the amino acid transport complex. Orthologous to human SLC7A5 (solute carrier family 7 member 5) and SLC7A8 (solute carrier family 7 member 8).
4	WBGene00000005	aat-4		Predicted to have L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in lysinuric protein intolerance. Orthologous to human SLC7A6 (solute carrier family 7 member 6) and SLC7A7 (solute carrier family 7 member 7).