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+# CellSIUS: Cell Subtype Identification from Upregulated gene Sets
+CellSIUS is an R package enabling the identification and characterization
+of (rare) cell sub-populations from complex scRNA-seq datasets:
+it takes as input expression values of N cells grouped into M(>1)
+clusters. Within each cluster, genes with a bimodal distribution
+are selected and only genes with cluster-specific expression are
+retained. Among these candidate marker genes, sets with correlated
+expression patterns are identified by graph-based clustering.
+Finally, cells are assigned to subgroups based on their average
+expression of each gene set. The CellSIUS algorithm output provides the
+rare/ sub cell types by cell indices and their transcriptomic signatures.
+
+## Reference
+Wegmann *et Al.*, **CellSIUS provides sensitive and specific detection of rare cell populations from complex single cell RNA-seq data**, Genome Biology, 2019 [accepted]
+