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Exploratory Graphics for PKPD data

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Overview

This repository displays suggested plots to pursue when exploring different PK/PD datasets, with a focus on exploring the Dose-Exposure-Response relationship. This site is a collection of exploratory plots and code, and could serve as a checklist of graphs someone might create for certain projects.

Many of the codes on the site use functions that we have found to be helpful while exploring PK/PD data. We compiled these helpful functions into the xgxr R-package, which is available on CRAN, and GitHub.

The contents of the xgx repository are as follows:

  • The index.html file is the main page that links to all others.
  • The majority of files and folders in the root directory are for displaying the website.
  • The files most likely to be of interest to you are stored in these 3 subdirectories
    • Data - contains the datasets
    • R - contains R functions
    • Rmarkdown - contains Rmarkdown documents that make up the subpages
  • If you update any of the files in the Rmarkdown folder, then to recompile the site, execute "Rmarkdown/000_render_site.R" in R

Most of the Rmarkdown scripts use caching so that recompiling is quick. However, when developing the site, if you change any dependencies (e.g. functions in the R folder or data in the Data folder) you should delete the cache. This means deleting all the folders in Rmarkdown that end in "_cache" DO NOT DELETE SiteResources.

In order to add links to the website, do the following:

  • Edit the Rmarkdown/_site.yml. Under the menu of interest, add a text and href entry - follow other examples
  • Edit the Rmarkdown/SiteResources/nav_icon.html. Under the menu of interest, add the link and name.
  • Then recompile with 000_render_site.R

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