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tisimpson committed Feb 9, 2024
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Expand Up @@ -15,6 +15,5 @@ Heterogeneity in human diseases presents challenges in diagnosis and treatments
MOGDx incorporates a network taxonomy for data integration and utilises a graph neural network architecture for classification. Networks con be easily integrated, can readily handle missing data, and have been used in a wide variety of biomedical applications in the unsupervised setting. Graph Neural Networks (GNN) have shown powerful classification performance on several benchmark network datasets. The use of GNN's in a supervised setting for disease classification is a promising avenue to redefine heterogenous diseases.

The performance of MOGDx was benchmarked on three distinct datasets from The Cancer Genome Atlas ([TCGA](https://www.cancer.gov/ccg/research/genome-sequencing/tcga)) for breast invasive carcinoma, kidney cancer, and low grade glioma. MOGDx demonstrated state-of-the-art performance and an ability to identify relevant multi-omic markers in each task. It did so while integrating more genomic measures with greater patient coverage compared to other network integrative methods. MOGDx is available to download from [Github](https://github.com/biomedicalinformaticsgroup/MOGDx).
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For more information find the preprint to our paper online [here](https://www.medrxiv.org/content/10.1101/2023.07.09.23292410v2)

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