cadd2vcf is a tool to assist in using CADD scores to modify and annotate a VCF to VCF specification. It will also deal with situations where there are differences in contig chr-prefix between the VCF and CADD scores. More information on CADD scores can be found here.
Installation is available via conda.
conda install -c bioconda cadd2vcf
Usage: ./cadd2vcf [options] <vcf(can be gzipped)> <cadd.tsv (can be gzippped)>
cadd2vcf: Annotate vcf with CADD Report
-b --build Genome build used to generate CADD file (GRCh37 or GRCh38) default: GRCh38
-h --help This help information.