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Evaluate profile normalization strategies #39

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gwaybio opened this issue May 15, 2020 · 0 comments
Open

Evaluate profile normalization strategies #39

gwaybio opened this issue May 15, 2020 · 0 comments
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Experiment Discusses the rationale, results, and implications of an isolated experiment

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gwaybio commented May 15, 2020

Currently, all profiles are normalized based on mad_robustize. We can use this repository to systematically evaluate if one strategy is better.

Rationale

As noted in #4 (comment)

The default in cytominer_scripts/normalize.R is robustize. I assume that I should continue using this method.

Yes. Rationale: mostly empirical – robustize resulted in higher (compared to standardize) replicate correlations of Level 4 across a few experiments we tested this in.
@gwaybio gwaybio mentioned this issue May 15, 2020
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@gwaybio gwaybio added the Experiment Discusses the rationale, results, and implications of an isolated experiment label May 22, 2020
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