Single-cell high-throughput sequencing, a major breakthrough in life sciences, allows us to access the integrated molecular profiles of thousands of cells in a single experiment. This abundance of data provides tremendous power to unveil unknown cellular mechanisms. However, single-cell data are so massive and complex that it has become challenging to give clues to their underlying biological processes.
The machine learning for integrative genomics G5 group works at the interphase of machine learning and genomics, developing methods exploiting the full richness and complementarity of the available single-cell data to derive actionable biological knowledge.
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| MOWGLI: Integrating paired multimodal single-cell data | HuMMuS: Molecular mechanisms from multi-omics single-cell data | scConfluence: Integrating unpaired multimodal single-cell data | scPrint: Transcriptomic foundation model for gene network inference and more |
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| CIRCE: Predict cis-regulatory interactions between DNA regions | |||
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| scDataLoader: a dataloader to work with large single cell datasets from lamindb | benGRN: Awesome Benchmark of Gene Regulatory Networks | GRnnData: Awesome GRN enhanced AnnData toolkit |
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