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Systole is an open-source Python package implementing simple tools for working with cardiac signals for psychophysiology research. In particular, the package provides tools to pre-process, visualize, and analyze cardiac data. This includes tools for data epoching, artefact detection, artefact correction, evoked heart rate analyses, heart rate variability analyses, circular statistical approaches to analysing cardiac cycles, and synchronising stimulus presentation with different cardiac phases via Psychopy.

The documentation can be found under the following link.

If you have questions, you can ask them in the Gitter chat.

How to cite?

If you are using Systole in a publication we ask you to cite the following paper:

Legrand, N. & Allen, M., (2022). Systole: A python package for cardiac signal synchrony and analysis. Journal of Open Source Software, 7(69), 3832, https://doi.org/10.21105/joss.03832

Installation

Systole can be installed using pip:

pip install systole

The following packages are required to use Systole:

• Numpy (>=1.15)
• SciPy (>=1.3.0)
• Pandas (>=0.24)
• Numba (>=0.51.2)
• Seaborn (>=0.9.0)
• Matplotlib (>=3.0.2)
• Bokeh (>=2.3.3)
• pyserial (>=3.4)
• setuptools (>=38.4)
• requests (>=2.26.0)
• tabulate (>=0.8.9)

The Python version should be 3.7 or higher.

Tutorials

For an introduction to Systole and cardiac signal analysis, you can refer to the following tutorial:

Cardiac signal analysis
Detecting cardiac cycles
Detecting and correcting artefats
Heart rate variability
Instantaneous and evoked heart rate
Working with BIDS folders

Getting started

from systole import import_dataset1

# Import ECg recording
signal = import_dataset1(modalities=['ECG']).ecg.to_numpy()

Signal extraction and interactive plotting

The package integrates a set of functions for interactive or non interactive data visualization based on Matplotlib and Bokeh.

from systole.plots import plot_raw

plot_raw(signal[60000 : 120000], modality="ecg", backend="bokeh",
            show_heart_rate=True, show_artefacts=True, figsize=300)

Artefacts detection and rejection

Artefacts can be detected and corrected in the RR interval time series or the peaks vector using the method proposed by Lipponen & Tarvainen (2019).

from systole.detection import ecg_peaks
from systole.plots import plot_subspaces

# R peaks detection
signal, peaks = ecg_peaks(signal, method='pan-tompkins', sfreq=1000)

plot_subspaces(peaks, input_type="peaks", backend="bokeh")

Heart rate variability analysis

Systole implements time-domain, frequency-domain and non-linear HRV indices, as well as tools for evoked heart rate analysis.

from bokeh.layouts import row
from systole.plots import plot_frequency, plot_poincare

row(
    plot_frequency(peaks, input_type="peaks", backend="bokeh", figsize=(300, 200)),
    plot_poincare(peaks, input_type="peaks", backend="bokeh", figsize=(200, 200)),
    )

Online systolic peak detection, cardiac-stimulus synchrony, and cardiac circular analysis

The package natively supports recording of physiological signals from the following setups: - Nonin 3012LP Xpod USB pulse oximeter together with the Nonin 8000SM 'soft-clip' fingertip sensors (USB). - Remote Data Access (RDA) via BrainVision Recorder together with Brain product ExG amplifier (Ethernet).

Interactive visualization of BIDS structured datasets

from systole.viewer import Viewer

view = Viewer(
    input_folder="/BIDS/folder/path/",
    pattern="task-mytask",
    modality="beh",
    signal_type="ECG"
)

Inserting and removing peaks

Annotating bad segments

Development

This module was created and is maintained by Nicolas Legrand and Micah Allen (ECG group, https://the-ecg.org/). If you want to contribute, feel free to contact one of the developers, open an issue or submit a pull request.

This program is provided with NO WARRANTY OF ANY KIND.

Acknowledgements

This software and the ECG are supported by a Lundbeckfonden Fellowship (R272-2017-4345), and the AIAS-COFUND II fellowship programme that is supported by the Marie Skłodowska-Curie actions under the European Union’s Horizon 2020 (Grant agreement no 754513), and the Aarhus University Research Foundation.

Systole was largely inspired by pre-existing toolboxes dedicated to heartrate variability and signal analysis.

• HeartPy: https://python-heart-rate-analysis-toolkit.readthedocs.io/en/latest/
• hrv: https://github.com/rhenanbartels/hrv
• pyHRV: https://pyhrv.readthedocs.io/en/latest/index.html
• ECG-detector: https://github.com/berndporr/py-ecg-detectors
• Pingouin: https://pingouin-stats.org/
• NeuroKit2: https://github.com/neuropsychology/NeuroKit

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