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Add a filtering step by canonical chromosomes before spliting by chromosomes #19

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mAGLAVE opened this issue Aug 30, 2024 · 0 comments
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enhancement New feature or request

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mAGLAVE commented Aug 30, 2024

Idea of optimization (to test for memory and time consuming):

Actually:

  1. concat all bam files from the alignement.
  2. split by chromsome (allow to filter to keep canonical chromosomes) -> used for methylation calling.
  3. reconcat all bam files -> used for variants calling and QC.

That could be better:

  1. concat all bam files from the alignement.
  2. filter the bam to keep canonical chromosomes -> used for variants calling and QC.
  3. split by chromsome -> used for methylation calling.

The advantage is not having to do the splitting if we don't do the methylation.

@mAGLAVE mAGLAVE added the enhancement New feature or request label Aug 30, 2024
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